Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation.

Autor: Chowdhury NU; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Cephus JY; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America., Henriquez Pilier E; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Wolf MM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Madden MZ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Kuehnle SN; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America., McKernan KE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Jennings EQ; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America., Arner EN; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America., Heintzman DR; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Chi C; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Sugiura A; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Stier MT; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America., Voss K; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Ye X; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America., Scales KL; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America., Krystofiak ES; Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America., Gandhi VD; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America., Guzy RD; Department of Medicine, University of Wisconsin, Madison, United States of America., Cahill KN; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America., Sperling AI; Department of Medicine, University of Virginia, Charlottesville, United States of America., Peebles RS Jr; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America., Rathmell JC; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America., Newcomb DC; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.

HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma.

Autor: Bacigalupa ZA; Department of Medicine.; Department of Pathology, Microbiology, and Immunology, and.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Arner EN; Department of Medicine.; Department of Pathology, Microbiology, and Immunology, and., Vlach LM; Department of Medicine., Wolf MM; Department of Medicine.; Department of Pathology, Microbiology, and Immunology, and., Brown WA; Department of Medicine., Krystofiak ES; Cell Imaging Shared Resource, Vanderbilt University, Nashville, Tennessee, USA., Ye X; Department of Pathology, Microbiology, and Immunology, and., Hongo RA; Department of Medicine.; Department of Pathology, Microbiology, and Immunology, and., Landis M; Department of Medicine.; Department of Pathology, Microbiology, and Immunology, and., Amason EK; Department of Medicine., Beckermann KE; Department of Medicine., Rathmell WK; Department of Medicine.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Rathmell JC; Department of Pathology, Microbiology, and Immunology, and.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Jun 17; Vol. 134 (12). Date of Electronic Publication: 2024 Jun 17.

Adhesion-based capture stabilizes nascent microvilli at epithelial cell junctions.

Autor: Cencer CS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Silverman JB; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Meenderink LM; Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN 37232, USA; United States Department of Veterans Affairs, Tennessee Valley Health Care System, Nashville, TN 37212, USA., Krystofiak ES; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Millis BA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37235, USA., Tyska MJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: matthew.tyska@vanderbilt.edu.

Publikováno v: Developmental cell [Dev Cell] 2023 Oct 23; Vol. 58 (20), pp. 2048-2062.e7. Date of Electronic Publication: 2023 Oct 12.

Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus.

Autor: Voss K; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Sewell AE; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Krystofiak ES; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Gibson-Corley KN; Division of Comparative Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Young AC; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Basham JH; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Sugiura A; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Arner EN; Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Beavers WN; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Kunkle DE; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA., Dickson ME; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Needle GA; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA., Skaar EP; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, TN, USA., Rathmell WK; Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ormseth MJ; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, TN, USA., Major AS; Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, TN, USA., Rathmell JC; Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Publikováno v: Science immunology [Sci Immunol] 2023 Jan 13; Vol. 8 (79), pp. eabq0178. Date of Electronic Publication: 2023 Jan 13.

Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.

Autor: Weiss A; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Murdoch CC; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Edmonds KA; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Jordan MR; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Monteith AJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Perera YR; Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA., Rodríguez Nassif AM; Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA., Petoletti AM; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Beavers WN; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Munneke MJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Drury SL; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Krystofiak ES; Cell Imaging Shared Resource, Vanderbilt University, Nashville, TN 37232, USA., Thalluri K; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Wu H; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Kruse ARS; Departments of Chemistry and Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37235, USA., DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Caprioli RM; Departments of Chemistry and Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37235, USA., Spraggins JM; Departments of Chemistry and Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN 37235, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA., Chazin WJ; Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA., Giedroc DP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA. Electronic address: giedroc@indiana.edu., Skaar EP; Department of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: eric.skaar@vumc.org.

Publikováno v: Cell [Cell] 2022 Jun 09; Vol. 185 (12), pp. 2148-2163.e27. Date of Electronic Publication: 2022 May 17.