Výsledky vyhledávání - "Krystina M. Neuman"

Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons

Autor: Yuliya Voskobiynyk, Timothy F. Musial, Gary X. D'Souza, Daniel A. Nicholson, Viviana Jimenez, Natividad Ybarra, Annalise E. Rogalsky, Loreece G. Haddad, John F. Disterhoft, Elizabeth Molina-Campos, Matthew L. Russo, Dane M. Chetkovich, Gabriel Carballo, M. Matthew Oh, Krystina M. Neuman

Publikováno v: Neurobiology of Aging. 106:207-222

The hippocampus is vulnerable to deterioration in Alzheimer's disease (AD). It is, however, a heterogeneous structure, which may contribute to the differential volumetric changes along its septotemporal axis during AD progression. Here, we investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2778797655a386e5ee0767bcfe47409d
https://doi.org/10.1016/j.neurobiolaging.2021.06.018

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Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer’s disease

Publikováno v: Neurobiology of learning and memory 154, 141-157 (2018). doi:10.1016/j.nlm.2018.06.004

Voltage-gated ion channels are critical for neuronal integration. Some of these channels, however, are mis-regulated in several neurological disorders, causing both gain- and loss-of-function channelopathies in neurons. Using several transgenic mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edbb564e58b08463b6143441f802c0b
https://europepmc.org/articles/PMC6434702/

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Evidence for Alzheimer’s disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons

Autor: Malerie L. Wolke, Kwang-Jin Oh, Stephen W. Scheff, Timothy F. Musial, Daniel A. Nicholson, Eric W. Buss, Andrea L. Price, Elizabeth Molina-Campos, Krystina M. Neuman, Elliott J. Mufson

Publikováno v: Brain Structure and Function. 220:3143-3165

Alzheimer’s disease (AD) is associated with alterations in the distribution, number, and size of inputs to hippocampal neurons. Some of these changes are thought to be neurodegenerative, whereas others are conceptualized as compensatory, plasticity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5290a7fca3ebf410e987bbcef85d7841
https://doi.org/10.1007/s00429-014-0848-z

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Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus

Autor: Daniel Johnston, Krystina M. Neuman, Daniel A. Nicholson, Eric W. Buss, Laurea M. Diaz, Kelly A. Dougherty, Dane M. Chetkovich

Publikováno v: Journal of Neurophysiology. 109:1940-1953

The rodent hippocampus can be divided into dorsal (DHC) and ventral (VHC) domains on the basis of behavioral, anatomical, and biochemical differences. Recently, we reported that CA1 pyramidal neurons from the VHC were intrinsically more excitable tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e00fbb2a53c3d13a42f956c4d67ffc7
https://doi.org/10.1152/jn.00010.2013

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