Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Krystian, Pluta"'
Autor:
Małgorzata Jeleń, Krystian Pluta, Małgorzata Szmielew, Beata Morak-Młodawska, Kinga Herman, Klaudia Giercuszkiewicz, Anna Kasprzycka, Magdalena Skonieczna
Publikováno v:
Molecules, Vol 28, Iss 7, p 3248 (2023)
A series of novel double-angularly condensed diquinothiazines with aminoalkyl, amidoalkyl, sulfonamidoalkyl, and substituted phenyl groups was designed, synthesized, and evaluated for their anticancer activity against four selected human tumor cell l
Externí odkaz:
https://doaj.org/article/45465691b0cf4428b2088d6e3478fa71
Autor:
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz, Kinga Suwińska, Aleksander Shkurenko, Zenon Czuba, Magdalena Jurzak
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1298-1306 (2019)
10H-1,9-diazaphenothiazine was obtained in the sulphurisation reaction of diphenylamine with elemental sulphur and transformed into new 10-substituted derivatives, containing alkyl and dialkylaminoalkyl groups at the thiazine nitrogen atom. The 1,9-d
Externí odkaz:
https://doaj.org/article/11d1184f83e546758e3026d21f5efede
Publikováno v:
Life, Vol 11, Iss 3, p 206 (2021)
Azaphenothiazines are the largest and most perspective group of modified phenothiazines, and they exhibit variety of biological activities. The review sums up the current knowledge on the anticancer activity of isomeric pyridobenzothiazines and dipyr
Externí odkaz:
https://doaj.org/article/7d2695b638ce4ee1ae2d7479d51bad19
Autor:
Jakub Jończyk, Justyna Godyń, Ewelina Stawarska, Beata Morak-Młodawska, Małgorzata Jeleń, Krystian Pluta, Barbara Malawska
Publikováno v:
Molecules, Vol 25, Iss 11, p 2604 (2020)
The inverse correlation observed between Alzheimer’s disease (AD) and cancer has prompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that possess anticancer properties. With the use of in silico and in vitro scre
Externí odkaz:
https://doaj.org/article/1a61fca694ef43b1a61990b7f12842f8
Autor:
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Jeleń, Małgorzata Latocha, Dariusz Kuśmierz
Publikováno v:
Proceedings, Vol 22, Iss 1, p 85 (2019)
Cancer has now become a global problem and been ranked as the top leading cause of deathworldwide after cardiovascular disease [...]
Externí odkaz:
https://doaj.org/article/3be95246c3c64e169ab83d9f0a5f6256
Autor:
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz
Publikováno v:
Molecules, Vol 24, Iss 2, p 267 (2019)
New 10-substituted derivatives of 3,6-diazaphenothiazine, containing the triple bond linker terminated with tertiary cyclic and acyclic amine groups, were synthesized and screened for their anticancer action. The compounds exhibited varied anticancer
Externí odkaz:
https://doaj.org/article/fecd422801a34bd19fbe53c08921551a
Autor:
Leon Strzadala, Anna Fiedorowicz, Edyta Wysokinska, Ewa Ziolo, Małgorzata Grudzień, Malgorzata Jelen, Krystian Pluta, Beata Morak-Mlodawska, Michal Zimecki, Wojciech Kalas
Publikováno v:
Molecules, Vol 23, Iss 10, p 2443 (2018)
An azaphenothiazine derivative, 6-chloroethylureidoethyldiquino[3,2-b;2′,3′-e][1,4]thiazine (DQT), has recently been shown to exhibit immunosuppressive activities in mouse models. It also inhibited the expression of CXCL10 at the protein level, a
Externí odkaz:
https://doaj.org/article/25a57afd18f44ac39b8941184b3cf559
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 42:563-569
The lipophilicity parameters (logPcalcd, RM0 and logPTLC) of 17 new anti-proliferative and anti-inflammatory tetracyclic 6-substituted 9-fluoroquinobenzothiazines were determined theoretica...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d5ffab85b9571235244d4e92249d2f
https://doi.org/10.1080/10826076.2019.1636389
https://doi.org/10.1080/10826076.2019.1636389
Autor:
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Dariusz Kuśmierz, Małgorzata Jeleń, Kinga Suwińska
Publikováno v:
Bioorganic Chemistry. 87:810-820
We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2′-dichloro-3,3′-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines. The pentacyclic diquinothiazine ring syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd36887c4d9d14289d7b343125c90453
https://doi.org/10.1016/j.bioorg.2019.04.005
https://doi.org/10.1016/j.bioorg.2019.04.005
Autor:
Małgorzata Latocha, Magdalena Jurzak, Aleksander Shkurenko, Krystian Pluta, Kinga Suwinska, Zenon P. Czuba, Beata Morak-Młodawska, Małgorzata Jeleń, Dariusz Kuśmierz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1298-1306 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
10H-1,9-diazaphenothiazine was obtained in the sulphurisation reaction of diphenylamine with elemental sulphur and transformed into new 10-substituted derivatives, containing alkyl and dialkylaminoalkyl groups at the thiazine nitrogen atom. The 1,9-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ac3c5d467001451f7f33bfd4a11079
https://doaj.org/article/11d1184f83e546758e3026d21f5efede
https://doaj.org/article/11d1184f83e546758e3026d21f5efede