Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Krystel El Hage"'
Autor:
Krystel El Hage, Nicolas Babault, Olek Maciejak, Bénédicte Desforges, Pierrick Craveur, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie-Jeanne Clement, Vandana Joshi, Ahmed Bouhss, Liya Wang, Cyril Bauvais, David Pastré
Publikováno v:
eLife, Vol 12 (2023)
RNA-protein interactions (RPIs) are promising targets for developing new molecules of therapeutic interest. Nevertheless, challenges arise from the lack of methods and feedback between computational and experimental techniques during the drug discove
Externí odkaz:
https://doaj.org/article/fba7b44d6c2f4d60b2a3433ce6ea930d
Autor:
Anastasiia Samsonova, Krystel El Hage, Bénédicte Desforges, Vandana Joshi, Marie-Jeanne Clément, Guillaume Lambert, Hélène Henrie, Nicolas Babault, Pierrick Craveur, Rachid C. Maroun, Emilie Steiner, Ahmed Bouhss, Alexandre Maucuer, Dmitry N. Lyabin, Lev P. Ovchinnikov, Loic Hamon, David Pastré
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 wit
Externí odkaz:
https://doaj.org/article/15258b4c3a3942419e49124926949c3e
Autor:
Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss
Publikováno v:
eLife, Vol 10 (2021)
TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains h
Externí odkaz:
https://doaj.org/article/de0ec8831ecd4f1da1a28a35d038e526
Autor:
Perla El Darazi, Léa El Khoury, Krystel El Hage, Richard G. Maroun, Zeina Hobaika, Jean-Philip Piquemal, Nohad Gresh
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The HIV-1 integrase (IN) is a major target for the design of novel anti-HIV inhibitors. Among these, three inhibitors which embody a halobenzene ring derivative (HR) in their structures are presently used in clinics. High-resolution X-ray crystallogr
Externí odkaz:
https://doaj.org/article/e387c926bd5a426e8d1f390f3ec0cd9a
Autor:
Léa El Khoury, Krystel El Hage, Jean-Philip Piquemal, Serge Fermandjian, Richard G. Maroun, Nohad Gresh, Zeina Hobaika
Publikováno v:
PeerJ Physical Chemistry, Vol 1, p e6 (2019)
Three integrase strand transfer inhibitors are in intensive clinical use, raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). The onset of integrase resistance mutations limits their therapeutic efficiency. As put forth earlier, the drug af
Externí odkaz:
https://doaj.org/article/5f06c5a16c3c4158b12d768262ace22d
Autor:
Krystel El Hage, Jean-Philip Piquemal, Nassima Oumata, Laurent Meijer, Hervé Galons, Nohad Gresh
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3467-3474 (2017)
Externí odkaz:
https://doaj.org/article/b7b5d109237c4b8c87708b796ba80783
Publikováno v:
eLife, Vol 8 (2019)
We recently reported that molecular dynamics simulations for hemoglobin require a surprisingly large box size to stabilize the T(0) state relative to R(0), as observed in experiments (El Hage et al., 2018). Gapsys and de Groot have commented on this
Externí odkaz:
https://doaj.org/article/cf0ccba87d8f4b51a0db52174f9675af
Publikováno v:
eLife, Vol 7 (2018)
Recent molecular dynamics (MD) simulations of human hemoglobin (Hb) give results in disagreement with experiment. Although it is known that the unliganded (T[Formula: see text]) and liganded (R[Formula: see text]) tetramers are stable in solution, th
Externí odkaz:
https://doaj.org/article/de9a45aec69a4949894030cbef4d5507
Autor:
Krystel El Hage, Sebastian Brickel, Sylvain Hermelin, Geoffrey Gaulier, Cédric Schmidt, Luigi Bonacina, Siri C. van Keulen, Swarnendu Bhattacharyya, Majed Chergui, Peter Hamm, Ursula Rothlisberger, Jean-Pierre Wolf, Markus Meuwly
Publikováno v:
Structural Dynamics, Vol 5, Iss 1, Pp 019901-019901-1 (2018)
Externí odkaz:
https://doaj.org/article/38bc7a46a8234a7f80a290bb870ed1aa
Autor:
Krystel El Hage, Sebastian Brickel, Sylvain Hermelin, Geoffrey Gaulier, Cédric Schmidt, Luigi Bonacina, Siri C. van Keulen, Swarnendu Bhattacharyya, Majed Chergui, Peter Hamm, Ursula Rothlisberger, Jean-Pierre Wolf, Markus Meuwly
Publikováno v:
Structural Dynamics, Vol 4, Iss 6, Pp 061507-061507-28 (2017)
This review provides a comprehensive overview of the structural dynamics in topical gas- and condensed-phase systems on multiple length and time scales. Starting from vibrationally induced dissociation of small molecules in the gas phase, the questio
Externí odkaz:
https://doaj.org/article/85d6ec3dcd434cf7acfaf985701aac3c