Výsledky vyhledávání - "Krystal Matthews"

Akademický článek

A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

Autor: Lindsey A. Moser, Lisbeth Ramirez-Carvajal, Vinita Puri, Steven J. Pauszek, Krystal Matthews, Kari A. Dilley, Clancy Mullan, Jennifer McGraw, Michael Khayat, Karen Beeri, Anthony Yee, Vivien Dugan, Mark T. Heise, Matthew B. Frieman, Luis L. Rodriguez, Kristen A. Bernard, David E. Wentworth, Timothy B. Stockwell, Reed S. Shabman

Publikováno v: mSystems, Vol 1, Iss 3 (2016)

ABSTRACT Several biosafety level 3 and/or 4 (BSL-3/4) pathogens are high-consequence, single-stranded RNA viruses, and their genomes, when introduced into permissive cells, are infectious. Moreover, many of these viruses are select agents (SAs), and

Externí odkaz: https://doaj.org/article/87969258f0004a58b311c0229c792bbc

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Akademický článek

Yeast based small molecule screen for inhibitors of SARS-CoV.

Autor: Matthew Frieman, Dipanwita Basu, Krystal Matthews, Justin Taylor, Grant Jones, Raymond Pickles, Ralph Baric, Daniel A Engel

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28479 (2011)

Severe acute respiratory coronavirus (SARS-CoV) emerged in 2002, resulting in roughly 8000 cases worldwide and 10% mortality. The animal reservoirs for SARS-CoV precursors still exist and the likelihood of future outbreaks in the human population is

Externí odkaz: https://doaj.org/article/1ba1d0ba5409485daa2ab893f907e543

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The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses

Autor: Chloe Keller, Lauren Baracco, Marisa McGrath, Alexander D. MacKerell, Matthew B. Frieman, Krystal Matthews, Peter B. Jahrling, James Logue, Michael R. Holbrook, Janie Liang, Lisa E. Hensley, Julie Dyall, Wenbo Yu, Stuart Weston

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences

The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals. We present work that the mammalian SKI complex is a broad-spectrum, host-directed, antiviral drug target. Yeast suppressor screening was utilized to find a functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effe8ad0f71554d0db9f5e56a91a0b11
https://pubmed.ncbi.nlm.nih.gov/33184176

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Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo

Autor: Susan R. Weiss, Krystal Matthews, Hanako M. Reyes, James Logue, Robert Haupt, Christopher M. Coleman, Stuart Weston, Yize Li, Matthew B. Frieman

Publikováno v: Journal of Virology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019 and has rapidly caused a pandemic, with over 20 million recorded COVID-19 cases in August 2020 (https://covid19.who.int/). There are no FDA-approved anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21e92fad6d61c424ce3dcdf445a60c8
https://doi.org/10.1128/jvi.01218-20

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Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2

Autor: Stuart, Weston, Christopher M, Coleman, Robert, Haupt, James, Logue, Krystal, Matthews, Yize, Li, Hanako M, Reyes, Susan R, Weiss, Matthew B, Frieman

Publikováno v: Journal of Virology

There are no FDA-approved antivirals for any coronavirus, including SARS-CoV-2. Numerous drugs are already approved for human use that may have antiviral activity and therefore could potentially be rapidly repurposed as antivirals. Here, we present d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::803d506d131cf928e21b419b0ada0b02
https://pubmed.ncbi.nlm.nih.gov/32817221

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Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo

Autor: James Logue, Rob Haupt, Christopher M. Coleman, Stuart Weston, Krystal Matthews, Matthew B. Frieman, Jeanne M. Sisk

SARS-CoV-2 emerged in China at the end of 2019 and has rapidly become a pandemic with roughly 2.7 million recorded COVID-19 cases and greater than 189,000 recorded deaths by April 23rd, 2020 (www.WHO.org). There are no FDA approved antivirals or vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e61937e56268b62dc0889ecdb09750

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A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication

Autor: Rob Haupt, Stuart Weston, Matthew B. Frieman, Rachel Lent, Krystal Matthews, Tami J. Kingsbury, Alexandra Vlk

Publikováno v: Journal of Virology

Viral proteins must intimately interact with the host cell machinery during virus replication. Here, we used the yeast Saccharomyces cerevisiae as a system to identify novel functional interactions between viral proteins and eukaryotic cells. Our wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070039c2a90a8ca7c52acd9bc959989a

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Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

Publikováno v: Proceedings of the National Academy of Sciences

Traditional approaches to antimicrobial drug development are poorly suited to combatting the emergence of novel pathogens. Additionally, the lack of small animal models for these infections hinders the in vivo testing of potential therapeutics. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55faf5193b385b5ba5dc08c6212c8d6

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Deficiency of Melanoma Differentiation–associated Protein 5 Results in Exacerbated Chronic Postviral Lung Inflammation

Autor: Matthew B. Frieman, Angela Franciska Haczku, Melissa D. Sánchez, Moyar Q. Ge, Krystal Matthews, Deepika Jain, Cynthia J. Koziol-White, Carolina B. López, Won-Keun Kim, Reynold A. Panettieri

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American journal of respiratory and critical care medicine, vol 189, iss 4

RationaleRespiratory viral infections can result in the establishment of chronic lung diseases. Understanding the early innate immune mechanisms that participate in the development of chronic postviral lung disease may reveal new targets for therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27359c2e0ccc3bf9b7aa0794f145eb57

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A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

Autor: Matthew B. Frieman, Mark T. Heise, Kristen A. Bernard, Krystal Matthews, Clancy W. Mullan, Anthony Yee, Vivien G. Dugan, Timothy B. Stockwell, Michael Khayat, Kari A. Dilley, Lisbeth Ramirez-Carvajal, Vinita Puri, Karen Beeri, Luis L. Rodriguez, David E. Wentworth, Lindsey A. Moser, Steven J. Pauszek, Reed S. Shabman, Jennifer McGraw

Publikováno v: mSystems
mSystems, Vol 1, Iss 3, p e00039-15 (2016)
mSystems, Vol 1, Iss 3 (2016)

This report establishes and validates a standard operating procedure (SOP) for select agents (SAs) and other biosafety level 3 and/or 4 (BSL-3/4) RNA viruses to rapidly generate noninfectious, barcoded cDNA amenable for next-generation sequencing (NG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568beb75df15011d6a528aa80f828bfd
https://doi.org/10.1128/msystems.00039-15

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