Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Krystal A. Fontaine"'
Autor:
Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Jennifer M. Hayashi, Irene P. Chen, Mir M. Khalid, Nathan L. Meyers, Taha Y. Taha, Kristoffer E. Leon, Rahul K. Suryawanshi, Maria McCavitt-Malvido, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen P. Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model ove
Externí odkaz:
https://doaj.org/article/2b9300e935d0405aa6dbdcaf44fa0f99
Autor:
Shahzada Khan, Irene Lew, Frank Wu, Linda Fritts, Krystal A. Fontaine, Sakshi Tomar, Martin Trapecar, Hesham M. Shehata, Melanie Ott, Christopher J. Miller, Shomyseh Sanjabi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing v
Externí odkaz:
https://doaj.org/article/eb3899d102fc43d5bbcf48369a070e1a
Autor:
Krystal A. Fontaine, Kristoffer E. Leon, Mir M. Khalid, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia A. Kaye, Priya S. Shah, Steve Finkbeiner, Nevan J. Krogan, Melanie Ott
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Zika virus (ZIKV) infection of neural progenitor cells (NPCs) in utero is associated with neurological disorders, such as microcephaly, but a detailed molecular understanding of ZIKV-induced pathogenesis is lacking. Here we show that in vitr
Externí odkaz:
https://doaj.org/article/ad85e194b2514640959c6776d3129874
Autor:
Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Mir M. Khalid, Nathan L. Meyers, Jennifer M. Hayashi, Taha Y. Taha, Kristoffer E. Leon, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott
As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that accurately recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052c9a607750875ea4cae9034f85ba7f
https://doi.org/10.1101/2022.08.02.502100
https://doi.org/10.1101/2022.08.02.502100
Autor:
Kristoffer E. Leon, Mir M. Khalid, Ryan A. Flynn, Krystal A. Fontaine, Thong T. Nguyen, G. Renuka Kumar, Camille R. Simoneau, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia Kaye, Priya S. Shah, Steven Finkbeiner, Nevan J. Krogan, Carolyn Bertozzi, Jan E. Carette, Melanie Ott
Publikováno v:
PLoS pathogens, vol 19, iss 1
Zika virus (ZIKV) infects fetal neural progenitor cells (NPCs) causing severe neurodevelopmental disorders in utero. Multiple pathways involved in normal brain development are dysfunctional in infected NPCs but how ZIKV centrally reprograms these pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a33ed0918ff4b5aeb2b80d2936016f
https://doi.org/10.1371/journal.ppat.1011070
https://doi.org/10.1371/journal.ppat.1011070
Autor:
Renuka Kumar, Ryan E Flynn, Tom Nguyen, Kristoffer E. Leon, Mir M. Khalid, David Jimenez-Morales, Jan E. Carette, Steve Finkbeiner, Camille R. Simoneau, Krystal A. Fontaine, Julia Kaye, Melanie Ott, Priya S. Shah, Sakshi Tomar, Nevan J. Krogan, Mariah Dunlap, Carolyn R. Bertozzi
Zika virus (ZIKV) is a mosquito-borne RNA virus that can infect fetuses in utero causing characteristic neurodevelopmental disorders including microcephaly. We previously showed that ZIKV infection downregulates expression of up-frameshift protein 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2559a969828ae79a2d2b98088de896f
https://doi.org/10.1101/2020.12.03.410837
https://doi.org/10.1101/2020.12.03.410837
Autor:
David E. Gordon, Weihao Zheng, Satish K. Pillai, Anke Meyer-Franke, Alexander Marson, Mohamed S. Bouzidi, Krystal A. Fontaine, Joseph Hiatt, Jonathan M. Budzik, Joel D. Ernst, Jason A. Wojcechowskyj, Ujjwal Rathore, Nevan J. Krogan, Kelsey M. Haas, Judd F. Hultquist, Theodore L. Roth, Jeffery S. Cox, Devin A. Cavero, Michael J. McGregor
SummaryGenome engineering of primary human cells with CRISPR-Cas9 has revolutionized experimental and therapeutic approaches to cell biology, but human myeloid-lineage cells have remained largely genetically intractable. We present a method for deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8290ee4feeb36c7da93a729b5cf03042
https://doi.org/10.1101/2020.03.13.991414
https://doi.org/10.1101/2020.03.13.991414
Autor:
Theodore L. Roth, Youjin V. Lee, Alexander Marson, Jeffery S. Cox, Jason A. Wojcechowskyj, Anke Meyer-Franke, David Wu, Jonathan M. Budzik, Mohamed S. Bouzidi, Vigneshwari Easwar Kumar, Krystal A. Fontaine, Weihao Zheng, Satish K. Pillai, Nevan J. Krogan, Eric Shifrut, Kelsey M. Haas, Joseph Hiatt, David E. Gordon, Ujjwal Rathore, Devin A. Cavero, Judd F. Hultquist, Eric V. Dang, Michael J. McGregor, Joel D. Ernst
Publikováno v:
Cell reports
Cell reports, vol 35, iss 6
Cell reports, vol 35, iss 6
SUMMARY Genome engineering of primary human cells with CRISPR-Cas9 has revolutionized experimental and therapeutic approaches to cell biology, but human myeloid-lineage cells have remained largely genetically intractable. We present a method for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f7aae3cf9bdaeb3651451764af9c41
https://pubmed.ncbi.nlm.nih.gov/33979618
https://pubmed.ncbi.nlm.nih.gov/33979618
Autor:
Shee-Mei Lok, Joshua M Costin, Yancey M Hrobowski, Andrew R Hoffmann, Dawne K Rowe, Petra Kukkaro, Heather Holdaway, Paul Chipman, Krystal A Fontaine, Michael R Holbrook, Robert F Garry, Victor Kostyuchenko, William C Wimley, Sharon Isern, Michael G Rossmann, Scott F Michael
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50995 (2012)
Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment. The mimetic peptide, DN59, consists of residues corresponding to the membrane interacting, amphipathic stem region of the dengue virus en
Externí odkaz:
https://doaj.org/article/bdc87599a35e4f68be5cecd625da32e3
Autor:
Joshua M Costin, Ekachai Jenwitheesuk, Shee-Mei Lok, Elizabeth Hunsperger, Kelly A Conrads, Krystal A Fontaine, Craig R Rees, Michael G Rossmann, Sharon Isern, Ram Samudrala, Scott F Michael
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 6, p e721 (2010)
Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resoluti
Externí odkaz:
https://doaj.org/article/f2a1eca4a9a5439db0bff740f5d6cbf3