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Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.

Autor: Bersell KR; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Yang T; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Mosley JD; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Glazer AM; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Hale AT; Biochemistry (A.T.H., J.D.Y.), Vanderbilt University, Nashville, TN., Kryshtal DO; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Kim K; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Steimle JD; Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, IL (J.D.S., I.P.M.)., Brown JD; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Salem JE; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Pharmacology, CIC-1901, Sorbonne University, Paris, France (J-E.S.).; Sorbonne Universités, UPMC Univ Paris 06, Faculty of Medicine, France (J-E.S.)., Campbell CC; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Hong CC; Department of Medicine, University of Maryland School of Medicine, Baltimore (C.C.H.)., Wells QS; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Biomedical Informatics (Q.S.W., D.M.R.), Vanderbilt University, Nashville, TN., Johnson AN; Molecular Physiology and Biophysics (A.N.J.), Vanderbilt University, Nashville, TN., Short L; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Blair MA; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Behr ER, Petropoulou E; Cardiology Clinical Academic Group, Molecular and Clinical Sciences Institute, St George's, University of London and St George's University Hospitals National Health Service Foundation Trust, London, UK (E.P., Y.J.)., Jamshidi Y; Cardiology Clinical Academic Group, Molecular and Clinical Sciences Institute, St George's, University of London and St George's University Hospitals National Health Service Foundation Trust, London, UK (E.P., Y.J.)., Benson MD; Cardiovascular Research Center (E.J.B., M.D.B., M.J.K., R.E.G.), Beth Israel Deaconess Hospital, Boston, MA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (M.D.B.)., Keyes MJ; Cardiovascular Research Center (E.J.B., M.D.B., M.J.K., R.E.G.), Beth Israel Deaconess Hospital, Boston, MA., Ngo D; Division of Pulmonary and Cardiovascular Medicine (D.N., R.E.G.), Beth Israel Deaconess Hospital, Boston, MA., Vasan RS; Boston University School of Medicine, MA (R.S.V., Q.Y.)., Yang Q; Boston University School of Medicine, MA (R.S.V., Q.Y.)., Gerszten RE; Cardiovascular Research Center (E.J.B., M.D.B., M.J.K., R.E.G.), Beth Israel Deaconess Hospital, Boston, MA.; Division of Pulmonary and Cardiovascular Medicine (D.N., R.E.G.), Beth Israel Deaconess Hospital, Boston, MA., Shaffer C; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Parikh S; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Sheng Q, Kannankeril PJ; Pediatrics (P.J.K.), Vanderbilt University, Nashville, TN., Moskowitz IP; Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, IL (J.D.S., I.P.M.)., York JD; Biochemistry (A.T.H., J.D.Y.), Vanderbilt University, Nashville, TN., Wang TJ; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Knollmann BC; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN., Roden DM; Departments of Pharmacology (K.R.B., A.M.G., D.O.K., K.K., J-E.S., C.C.C., Q.S.W., S.P., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN.; Biomedical Informatics (Q.S.W., D.M.R.), Vanderbilt University, Nashville, TN.

Publikováno v: Circulation [Circulation] 2023 Mar 07; Vol. 147 (10), pp. 824-840. Date of Electronic Publication: 2022 Dec 16.

RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.

Autor: Kryshtal DO; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.O.K., D.J.B., C.L.E., B.C.K.)., Blackwell DJ; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.O.K., D.J.B., C.L.E., B.C.K.)., Egly CL; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.O.K., D.J.B., C.L.E., B.C.K.)., Smith AN; Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., S.M.B., J.N.J.)., Batiste SM; Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., S.M.B., J.N.J.)., Johnston JN; Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., S.M.B., J.N.J.)., Laver DR; School of Biomedical Sciences and Pharmacy, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW, Australia (D.R.L.)., Knollmann BC; Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN (D.O.K., D.J.B., C.L.E., B.C.K.).

Publikováno v: Circulation research [Circ Res] 2021 Feb 05; Vol. 128 (3), pp. 321-331. Date of Electronic Publication: 2020 Dec 10.

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.

Autor: Batiste SM; Department of Chemistry, Vanderbilt University, Nashville, TN 37235., Blackwell DJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232., Kim K; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232., Kryshtal DO; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232., Gomez-Hurtado N; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232., Rebbeck RT; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455., Cornea RL; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455., Johnston JN; Department of Chemistry, Vanderbilt University, Nashville, TN 37235; jeffrey.n.johnston@vanderbilt.edu bjorn.knollmann@vanderbilt.edu., Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232; jeffrey.n.johnston@vanderbilt.edu bjorn.knollmann@vanderbilt.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Mar 12; Vol. 116 (11), pp. 4810-4815. Date of Electronic Publication: 2019 Feb 21.

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Autor: Parikh SS; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Blackwell DJ; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Gomez-Hurtado N; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Frisk M; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Wang L; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Kim K; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Dahl CP; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Fiane A; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Tønnessen T; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Kryshtal DO; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Louch WE; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.)., Knollmann BC; From the Vanderbilt Center for Arrhythmia Research and Therapeutics, Department of Medicine (S.S.P., D.J.B., N.G.-H., L.W., K.K., D.O.K., B.C.K.), Department of Pharmacology (S.S.P., B.C.K.), Vanderbilt University Medical School, Nashville, TN; Institute for Experimental Medical Research, Oslo University Hospital, Norway (M.F., T.T., W.E.L.); University of Oslo, Norway (M.F., T.T., W.E.L.); Department of Cardiology (C.P.D.), and Department of Cardiothoracic Surgery (A.F.), Oslo University Hospital Rikshospitalet, Norway; and Oslo University Hospital Ullevål, Norway (T.T.). bjorn.knollmann@vanderbilt.edu.

Publikováno v: Circulation research [Circ Res] 2017 Dec 08; Vol. 121 (12), pp. 1323-1330. Date of Electronic Publication: 2017 Oct 02.