Can Arginine Inhibit Insulin Aggregation? A Combined Protein Crystallography, Capillary Electrophoresis, and Molecular Simulation Study

Autor: Pavel Jungwirth, Tim Ganderton, Vladimír Palivec, Cristina M. Viola, Elise Duboué-Dijon, Tomáš Křížek, Andrzej M. Brzozowski, Kryštof Březina, Jiří Jiráček

Publikováno v: Journal of Physical Chemistry B
Journal of Physical Chemistry B, American Chemical Society, 2018, 122 (44), pp.10069-10076. ⟨10.1021/acs.jpcb.8b06557⟩

The oligomeric state of the storage form of human insulin in pancreas, which may be affected by several endogenous components of beta-cells storage granules such as arginine, is not known. Here, the effect of arginine on insulin oligomerisation is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6431cb1d44fe99426d1441ee43461fd
https://pubmed.ncbi.nlm.nih.gov/30153414