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Gene-directed enzyme prodrug therapy for osteosarcoma: Sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2

Autor: Oosterhoff, D., Witlox, M.A., van Beusechem, V.W., Haisma, H.J., Schaap, G.R., Bras, J., Kruyt, Wim, Molenaar, B., Boven, E., Wuisman, P.I., Pinedo, H.M., Gerritsen, W.R.

Publikováno v: Mol.Cancer Ther., 2(8), 765-771. AMER ASSOC CANCER RESEARCH

Despite improvement in the treatment of osteosarcoma (OS), there are still many patients who cannot benefit from current treatment modalities. This warrants exploration of new treatment options. To that end, we investigated gene-directed enzyme prodr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::97ad573796896c71775810ffacda4615
https://research.rug.nl/en/publications/351bbd2e-899b-43ff-8f59-54a39036afcf

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