Modular radical cross-coupling with sulfones enables access to sp³-rich (fluoro)alkylated scaffolds

Autor: Merchant, Rohan R., Edwards, Jacob T., Qin, Tian, Kruszyk, Monika M., Bi, Cheng, Che, Guanda, Bao, Deng-Hui, Qiao, Wenhua, Sun, Lijie, Collins, Michael R., Fadeyi, Olugbeminiyi O., Gallego, Gary M., Mousseau, James J., Nuhant, Philippe, Baran, Phil S.

Publikováno v: Science, 2018 Apr 01. 360(6384), 75-80.

Externí odkaz: https://www.jstor.org/stable/26498527

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

Autor: Shengyang,Ni, M. Padial, Natalia, Kingston, Cian, Vantourout, Julien C., Schmitt, Daniel C., Edwards, Jacob T, Kruszyk, Monika M., Merchand, Rohan R., Mykhailiuk, Pavel K., Sanchez, Brittany B., Yang, Shouliang, Perry, Matthew A., Gallego, Gary M., Mousseau, James J., Collins, Michael R., Cherney, Robert J., Lebed, Pavlo S., Chen, Jason S., Qin, Tian, Baran, Phil S.

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports the developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85762174601c698d5b09341429b1340a

Modular radical cross-coupling with sulfones enables access to sp ³ -rich (fluoro)alkylated scaffolds.

Autor: Merchant RR; Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Edwards JT; Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Qin T; Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Kruszyk MM; Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Bi C; Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Che G; Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China., Bao DH; Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China., Qiao W; Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China., Sun L; Asymchem Life Science (Tianjin), Tianjin Economic-Technological Development Zone, Tianjin 300457, China., Collins MR; Department of Chemistry, La Jolla Laboratories, Pfizer, 10770 Science Center Drive, San Diego, CA 92121, USA., Fadeyi OO; Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA., Gallego GM; Department of Chemistry, La Jolla Laboratories, Pfizer, 10770 Science Center Drive, San Diego, CA 92121, USA., Mousseau JJ; Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA., Nuhant P; Pfizer Medicinal Sciences, Eastern Point Road, Groton, CT 06340, USA., Baran PS; Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. pbaran@scripps.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2018 Apr 06; Vol. 360 (6384), pp. 75-80. Date of Electronic Publication: 2018 Feb 18.