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Infiltrating CD8 ⁺ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model.

Autor: Jorfi M; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA. mjorfi@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. mjorfi@mgh.harvard.edu.; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Charlestown, MA, USA. mjorfi@mgh.harvard.edu., Park J; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Hall CK; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., Lin CJ; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., Chen M; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., von Maydell D; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., Kruskop JM; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., Kang B; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., Choi Y; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA., Prokopenko D; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Irimia D; Harvard Medical School, Boston, MA, USA.; Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Charlestown, MA, USA.; Shriners Burns Hospital, Boston, MA, USA., Kim DY; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA. dkim@helix.mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. dkim@helix.mgh.harvard.edu., Tanzi RE; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA. tanzi@helix.mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. tanzi@helix.mgh.harvard.edu.

Publikováno v: Nature neuroscience [Nat Neurosci] 2023 Sep; Vol. 26 (9), pp. 1489-1504. Date of Electronic Publication: 2023 Aug 24.