Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Krushna C Patra"'
Autor:
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan
Publikováno v:
eLife, Vol 12 (2023)
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signal
Externí odkaz:
https://doaj.org/article/05fc37cffa674796bf7877b4353fc32a
Publikováno v:
eLife, Vol 7 (2018)
Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of pros
Externí odkaz:
https://doaj.org/article/6d4103e6d02a47d7be5bbd23795abd41
Autor:
Catherine S. Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Soeun Kang, Prashanth Bhaskar, Alexander R. Terry, Alexandre F. Aissa, Maxim V. Frolov, Krushna C. Patra, R. Brooks Robey, Nissim Hay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Hexokinase 2 expression is markedly induced in cancer cells and contributes to cancer cell metabolism. Here, the authors show that hexokinase 2 can contribute to the metastatic spread of cancer cells independently of its glycolytic function via inhib
Externí odkaz:
https://doaj.org/article/78bfbaa457e843ebaad6087dacfee23a
Autor:
Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher P. Long, Maciek R. Antoniewicz, Nissim Hay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Hexokinase 2 (HK2) is selectively upregulated in hepatocellular carcinoma (HCC). Here the authors show that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metform
Externí odkaz:
https://doaj.org/article/b4eb4726703e40cea6442db1aeb36e9f
Autor:
Meena Kathiresan, Sambhavi Animesh, Robert Morris, Johannes Kreuzer, Krushna C. Patra, Lei Shi, Joshua Merritt, Xunqin Yin, Cyril H. Benes, Nabeel Bardeesy, Wilhelm Haas
Aneuploidy and resulting gene copy number alterations (CNAs) are important hallmarks of human cancers. Since CNAs are not associated with dosage compensation in mRNA expression, cancer cells with a high CNA burden must harbor mechanisms to mitigate p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d013b24ee308593f89f34de21e5cf927
https://doi.org/10.1101/2023.05.04.539299
https://doi.org/10.1101/2023.05.04.539299
Autor:
Nabeel Bardeesy, Ryan B. Corcoran, Andrew X. Zhu, Dejan Juric, Gad Getz, Hiroshi Hirai, David T. Ting, Cyril H. Benes, William C. Hahn, A. John Iafrate, Alberto Bardelli, Robin K. Kelley, Rona Yaeger, James J. Harding, Vikram Deshpande, Kenneth K. Tanabe, Cristina R. Ferrone, Janet E. Murphy, Emily E. Van Seventer, Islam Baiev, Isobel J. Fetter, Ipsita Dey-Guha, Heather A. Shahzade, Brandon Nadres, Sachie Otsuki, Takeshi Sagara, Stephanie Reyes, Ron Arellano, Raul N. Uppot, Supriya K. Saha, Krushna C. Patra, Phuong Vu, Raymond W.S. Ng, Giulia Siravegna, Liudmila Elagina, Ignaty Leschiner, Srivatsan Raghavan, Jochen K. Lennerz, Ferran Fece de la Cruz, Leah Y. Liu, Lei Shi, Lipika Goyal
Primer sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb99477b084f5f1d03a05309707b9d7
https://doi.org/10.1158/2159-8290.22536626.v1
https://doi.org/10.1158/2159-8290.22536626.v1
Autor:
Nabeel Bardeesy, Ryan B. Corcoran, Andrew X. Zhu, Dejan Juric, Gad Getz, Hiroshi Hirai, David T. Ting, Cyril H. Benes, William C. Hahn, A. John Iafrate, Alberto Bardelli, Robin K. Kelley, Rona Yaeger, James J. Harding, Vikram Deshpande, Kenneth K. Tanabe, Cristina R. Ferrone, Janet E. Murphy, Emily E. Van Seventer, Islam Baiev, Isobel J. Fetter, Ipsita Dey-Guha, Heather A. Shahzade, Brandon Nadres, Sachie Otsuki, Takeshi Sagara, Stephanie Reyes, Ron Arellano, Raul N. Uppot, Supriya K. Saha, Krushna C. Patra, Phuong Vu, Raymond W.S. Ng, Giulia Siravegna, Liudmila Elagina, Ignaty Leschiner, Srivatsan Raghavan, Jochen K. Lennerz, Ferran Fece de la Cruz, Leah Y. Liu, Lei Shi, Lipika Goyal
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27311ab762443f6c05c898bba2700b67
https://doi.org/10.1158/2159-8290.22536629.v1
https://doi.org/10.1158/2159-8290.22536629.v1
Autor:
Nabeel Bardeesy, Ryan B. Corcoran, Andrew X. Zhu, Dejan Juric, Gad Getz, Hiroshi Hirai, David T. Ting, Cyril H. Benes, William C. Hahn, A. John Iafrate, Alberto Bardelli, Robin K. Kelley, Rona Yaeger, James J. Harding, Vikram Deshpande, Kenneth K. Tanabe, Cristina R. Ferrone, Janet E. Murphy, Emily E. Van Seventer, Islam Baiev, Isobel J. Fetter, Ipsita Dey-Guha, Heather A. Shahzade, Brandon Nadres, Sachie Otsuki, Takeshi Sagara, Stephanie Reyes, Ron Arellano, Raul N. Uppot, Supriya K. Saha, Krushna C. Patra, Phuong Vu, Raymond W.S. Ng, Giulia Siravegna, Liudmila Elagina, Ignaty Leschiner, Srivatsan Raghavan, Jochen K. Lennerz, Ferran Fece de la Cruz, Leah Y. Liu, Lei Shi, Lipika Goyal
ATP-competitive fibroblast growth factor receptor (FGFR) kinase inhibitors, including BGJ398 and Debio 1347, show antitumor activity in patients with intrahepatic cholangiocarcinoma (ICC) harboring activating FGFR2 gene fusions. Unfortunately, acquir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde233ec82d33cc1756742f9dcb77f63
https://doi.org/10.1158/2159-8290.c.6548189.v1
https://doi.org/10.1158/2159-8290.c.6548189.v1
Autor:
Pradip Raychaudhuri, Srilata Bagchi, Richard Benya, Adam Blunier, Dragana Kopanja, Krushna C. Patra, Jing Li, Indira Elangovan, Shaumick Bhattacharjee, Uppoor G. Bhat, Prashant V. Bommi, Nilotpal Roy
PDF file - 13093K, Supplementary Fig.1: Loss of DDB2 expression in human colon cancer. Supplementary Fig.2: Low magnification IHC data showing reduced expression of DDB2 in high grade colon cancer samples. Supplementary Fig.3: Depletion of DDB2 incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ac3af39c05282e3f8d7f809536de0d
https://doi.org/10.1158/0008-5472.22395558
https://doi.org/10.1158/0008-5472.22395558
Autor:
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57702eaa8f41296e52fffc2f1b15a79
https://doi.org/10.7554/elife.69521.sa2
https://doi.org/10.7554/elife.69521.sa2