Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach

Autor: Jerry J. Zimmerman, Silvia Cermelli, Krupa Arun Navalkar, Lester C. Permut, Erin Sullivan, Therese Seldon, Dayle Sampson, Adrian M. Piliponsky, Nicholas J. Shubin, Thomas D. Yager

Publikováno v: Critical care medicine. 48(1)

Objectives Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d116777134af36ba6201332ce9e229a
https://pubmed.ncbi.nlm.nih.gov/31714400

Validation of a host response assay, SeptiCyte LAB, for discriminating sepsis from systemic inflammatory response syndrome in the ICU

Autor: Marcus J. Schultz, Greg S. Martin, Dayle Sampson, Thomas D. Yager, Robert A. Balk, Silvia Cermelli, Tom van der Poll, Stella Hahn, Richard E. Rothman, Antony Rapisarda, Annette M. Esper, Steven M. Opal, Jordan A. Kempker, Shruti Bhide, Brian A. Fox, Mitchell M. Levy, Richard Bruce Brandon, Roslyn A. Brandon, Neil R. Aggarwal, Adey Tsegaye, Krupa Arun Navalkar, Majid Afshar, Mark Yoder, Russell R. Miller, John P. Burke, Emily R. Gilbert, Paul H. Mayo, Victoria Rothwell, Franco R. D'Alessio, Gourang P. Patel, Therese Seldon, Venkataramana K. Sidhaye, Roy F. Davis, James T. Kirk, Brendon P. Scicluna, Mangala Narasimhan, Leo McHugh, Richard Newman, Bert K. Lopansri, Peter M. C. Klein Klouwenberg, Jared A. Greenberg, Jorge P. Parada

Publikováno v: American journal of respiratory and critical care medicine, 198(7), 903-913. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine

A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe86da10b4868ef23566cd09454be03
https://pure.amc.nl/en/publications/validation-of-a-host-response-assay-septicyte-lab-for-discriminating-sepsis-from-systemic-inflammatory-response-syndrome-in-the-icu(9afff7c3-7587-40bd-9dd1-e75e460d9c47).html

Peptide based diagnostics: are random-sequence peptides more useful than tiling proteome sequences?

Autor: Phillip Stafford, Krupa Arun Navalkar, Stephan Albert Johnston

Publikováno v: Journal of immunological methods. 417

Diagnostics using peptide ligands have been available for decades. However, their adoption in diagnostics has been limited, not because of poor sensitivity but in many cases due to diminished specificity. Numerous reports suggest that protein-based r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e5bfc345095b9f6556bb4e2bb273e6
https://pubmed.ncbi.nlm.nih.gov/25497701

GuiTope: an application for mapping random-sequence peptides to protein sequences

Autor: Krupa Arun Navalkar, Phillip Stafford, Jack S Emery, Rebecca F. Halperin, Stephen Albert Johnston

Publikováno v: BMC Bioinformatics, Vol 13, Iss 1, p 1 (2012)
BMC Bioinformatics

Background Random-sequence peptide libraries are a commonly used tool to identify novel ligands for binding antibodies, other proteins, and small molecules. It is often of interest to compare the selected peptide sequences to the natural protein bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd663dabdf7e27dd83961ac47d54f94
https://doi.org/10.1186/1471-2105-13-1