Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice.

Autor: van Gemert Y; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Blom AB; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Di Ceglie I; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Walgreen B; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Helsen M; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Sloetjes A; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Vogl T; Institute of Immunology, University of Münster, Germany., Roth J; Institute of Immunology, University of Münster, Germany., Kruisbergen NNL; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., Pieterman EJ; Metabolic Health Research, TNO, Leiden, the Netherlands., Princen HMG; Metabolic Health Research, TNO, Leiden, the Netherlands., van der Kraan PM; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., van Lent PLEM; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands., van den Bosch MHJ; Experimental Rheumatology, Radboud university medical center, Nijmegen, the Netherlands. Electronic address: martijn.vandenbosch@radboudumc.nl.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2023 Jul; Vol. 31 (7), pp. 934-943. Date of Electronic Publication: 2023 Mar 08.

Activation of circulating monocytes by low-density lipoprotein-a risk factor for osteoarthritis?

Autor: Kruisbergen NNL; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands., van Gemert Y; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands., Blom AB; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands., van den Bosch MHJ; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands., van Lent PLEM; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Dec 23; Vol. 62 (1), pp. 42-51.

A single dose of anti-IL-1β antibodies prevents Western diet-induced immune activation during early stage collagenase-induced osteoarthritis, but does not ameliorate end-stage pathology.

Autor: Kruisbergen NNL; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Nik.Kruisbergen@radboudumc.nl., van Gemert Y; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Yvonne.vanGemert@radboudumc.nl., Walgreen B; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Birgitte.Walgreen@radboudumc.nl., Helsen MMA; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Monique.Helsen@radboudumc.nl., Slöetjes AW; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Annet.Sloetjes@radboudumc.nl., Koenders MI; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Marije.Koenders@radboudumc.nl., van de Loo FAJ; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Fons.vandeLoo@radboudumc.nl., Roth J; Institute of Immunology, University of Münster, Germany. Electronic address: rothj@uni-muenster.de., Vogl T; Institute of Immunology, University of Münster, Germany. Electronic address: vogl@uni-muenster.de., van der Kraan PM; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Peter.vanderKraan@radboudumc.nl., Blom AB; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Arjen.Blom@radboudumc.nl., van den Bosch MHJ; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Martijn.vandenBosch@radboudumc.nl., van Lent PLEM; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Peter.vanLent@radboudumc.nl.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2021 Oct; Vol. 29 (10), pp. 1462-1473. Date of Electronic Publication: 2021 Jul 21.

High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Autor: Ascone G; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Di Ceglie I; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., van den Bosch MHJ; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Kruisbergen NNL; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Walgreen B; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Sloetjes AW; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Lindhout E; Future Diagnostics Solutions (FDx), Wijchen, the Netherlands., Joosten LAB; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., van de Loo FAJ; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Koenders MI; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., van der Kraan PM; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., Blom AB; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands., van Lent PLEM; Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. peter.vanlent@radboudumc.nl.

Publikováno v: Clinical and experimental rheumatology [Clin Exp Rheumatol] 2019 Nov-Dec; Vol. 37 (6), pp. 983-993. Date of Electronic Publication: 2019 May 07.

The role of NOX2-derived reactive oxygen species in collagenase-induced osteoarthritis.

Autor: van Dalen SCM; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Stephanie.vanDalen@radboudumc.nl., Kruisbergen NNL; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Nik.Kruisbergen@radboudumc.nl., Walgreen B; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Birgitte.Walgreen@radboudumc.nl., Helsen MMA; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Monique.Helsen@radboudumc.nl., Slöetjes AW; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Annet.Sloetjes@radboudumc.nl., Cremers NAJ; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Niels.Cremers@radboudumc.nl., Koenders MI; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Marije.Koenders@radboudumc.nl., van de Loo FAJ; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Fons.vandeLoo@radboudumc.nl., Roth J; Institute of Immunology, University of Münster, Germany. Electronic address: rothj@uni-muenster.de., Vogl T; Institute of Immunology, University of Münster, Germany. Electronic address: vogl@uni-muenster.de., Blom AB; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Arjen.Blom@radboudumc.nl., van der Kraan PM; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Peter.vanderKraan@radboudumc.nl., van Lent PLEM; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Peter.vanLent@radboudumc.nl., van den Bosch MHJ; Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Martijn.vandenBosch@radboudumc.nl.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2018 Dec; Vol. 26 (12), pp. 1722-1732. Date of Electronic Publication: 2018 Sep 05.