Multiomics of iPSC‐derived ApoE3‐ and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism.

Autor: van der Kant, Rik, Blomberg, Niek, Erlebach, Lena, Feringa, Femke M, Heijneman, Jorin, Koppes, Sascha, Kruijff, Iris Daphne, McQuade, Amanda, Miramontes, Ricardo, Olivier‐Jimenez, Damien, Robert, Aiko, Thompson, Leslie M., Ori, Alessandro, Kronenberg‐Versteeg, Deborah, Mohammed, Yassene, Kampmann, Martin, Giera, Martin

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 13, Vol. 19, p1-2, 2p

Multi‐omic profiling of isogenic ApoE3/3 and ApoE4/4 iPSC‐derived astrocytes uncovers altered lipid metabolism and mitochondrial function of ApoE4 astrocytes.

Autor: Koppes, Sascha, Feringa, Femke M, Robert, Aiko, Kruijff, Iris Daphne, Olivier‐Jimenez, Damien, Erlebach, Lena, Thompson, Leslie M., Kronenberg‐Versteeg, Deborah, Ori, Alessandro, Mohammed, Yassene, Giera, Martin, van der Kant, Rik

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 13, Vol. 19, p1-1, 1p

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4.

Autor: Feringa FM; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands., Hertog SJK; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands., Wang L; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., Derks RJE; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., Kruijff I; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands., Erlebach L; German Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Heijneman J; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands., Miramontes R; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Pömpner N; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany., Blomberg N; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., Olivier-Jimenez D; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., Johansen LE; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands., Cammack AJ; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at UCL, University College London, London, UK., Giblin A; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at UCL, University College London, London, UK., Toomey CE; Department of Clinical and Molecular Neuroscience, Queen Square Institute of Neurology, University College London, London, UK., Rose IVL; Institute for Neurodegenerative Diseases and Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Yuan H; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Ward M; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Isaacs AM; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at UCL, University College London, London, UK., Kampmann M; Department of Biochemistry and Biophysics, Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA., Kronenberg-Versteeg D; German Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Lashley T; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK., Thompson LM; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Ori A; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany., Mohammed Y; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3A 0G4, Canada., Giera M; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., van der Kant R; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03.