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An antibiotic from an uncultured bacterium binds to an immutable target.

Autor: Shukla R; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Peoples AJ; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA., Ludwig KC; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Maity S; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands., Derks MGN; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., De Benedetti S; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Krueger AM; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands., Vermeulen BJA; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Harbig T; Integrative Transcriptomics, Center for Bioinformatics, University of Tübingen, 72070 Tübingen, Germany., Lavore F; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Kumar R; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Honorato RV; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Grein F; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany., Nieselt K; Integrative Transcriptomics, Center for Bioinformatics, University of Tübingen, 72070 Tübingen, Germany., Liu Y; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China., Bonvin AMJJ; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Baldus M; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Kubitscheck U; Clausius-Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Breukink E; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands., Achorn C; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA., Nitti A; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA., Schwalen CJ; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA., Spoering AL; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA., Ling LL; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA., Hughes D; NovoBiotic Pharmaceuticals, Cambridge, MA 02138, USA., Lelli M; Magnetic Resonance Center (CERM) and Department of Chemistry 'Ugo Schiff', University of Florence, via della Lastruccia 3, Sesto Fiorentino 50019, Italy; Consorzio Interuniversitario Risonanze Magnetiche MetalloProteine (CIRMMP), via Sacconi 6, Sesto Fiorentino 50019, Italy., Roos WH; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands., Lewis K; Antimicrobial Discovery Center, Northeastern University, Department of Biology, Boston, MA 02115, USA., Schneider T; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany. Electronic address: tschneider@uni-bonn.de., Weingarth M; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands. Electronic address: m.h.weingarth@uu.nl.

Publikováno v: Cell [Cell] 2023 Sep 14; Vol. 186 (19), pp. 4059-4073.e27. Date of Electronic Publication: 2023 Aug 22.

A new antibiotic from an uncultured bacterium binds to an immutable target.

Autor: Shukla R; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Peoples AJ; NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA., Ludwig KC; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Maity S; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands., Derks MGN; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands., de Benedetti S; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Krueger AM; Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Vermeulen BJA; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Lavore F; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Honorato RV; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Grein F; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany., Bonvin A; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Kubitscheck U; Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Breukink E; Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands., Achorn C; NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA., Nitti A; NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA., Schwalen CJ; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA., Spoering AL; NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA., Ling LL; NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA., Hughes D; NovoBiotic Pharmaceuticals, Cambridge, Massachusetts 02138, USA., Lelli M; Magnetic Resonance Center (CERM) and Department of Chemistry 'Ugo Schiff', University of Florence, via Sacconi 6, Sesto Fiorentino, 50019 Italy.; Consorzio Interuniversitario Risonanze Magnetiche MetalloProteine (CIRMMP), via Sacconi 6, Sesto Fiorentino, 50019 Italy., Roos WH; Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands., Lewis K; Antimicrobial Discovery Center, Northeastern University, Department of Biology, Boston, Massachusetts 02115, USA., Schneider T; Institute for Pharmaceutical Microbiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Weingarth M; NMR Spectroscopy, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 15. Date of Electronic Publication: 2023 May 15.

Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis.

Autor: Doll MA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA., Ray AR; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA., Salazar-González RA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA., Shah PP; Department of Medicine, University of Louisville, Louisville, Kentucky, USA., Vega AA; Department of Medicine, University of Louisville, Louisville, Kentucky, USA., Sears SM; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA., Krueger AM; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA., Hong KU; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA.; Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA., Beverly LJ; Department of Medicine, University of Louisville, Louisville, Kentucky, USA.; Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA., Hein DW; Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA.; Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA.

Publikováno v: Molecular carcinogenesis [Mol Carcinog] 2022 May; Vol. 61 (5), pp. 481-493. Date of Electronic Publication: 2022 Feb 08.

Executive and Social Functioning Across Development in Children and Adolescents With Prenatal Alcohol Exposure.

Autor: Rockhold MN; University of Minnesota, Minneapolis, MN, USA., Krueger AM; University of Minnesota, Minneapolis, MN, USA., de Water E; University of Minnesota, Minneapolis, MN, USA., Lindgren CW; University of Minnesota, Minneapolis, MN, USA., Sandness KE; University of Minnesota, Minneapolis, MN, USA., Eckerle JK; University of Minnesota, Minneapolis, MN, USA., Schumacher MJ; University of Minnesota, Minneapolis, MN, USA., Fink BA; University of Minnesota, Minneapolis, MN, USA., Boys CJ; University of Minnesota, Minneapolis, MN, USA., Carlson SM; University of Minnesota, Minneapolis, MN, USA., Fuglestad AJ; University of North Florida, Jacksonville, FL, USA., Mattson SN; San Diego State University, San Diego, CA, USA., Jones KL; University of California, San Diego, San Diego, CA, USA., Riley EP; San Diego State University, San Diego, CA, USA., Wozniak JR; University of Minnesota, Minneapolis, MN, USA.

Publikováno v: Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2021 Feb; Vol. 45 (2), pp. 457-469. Date of Electronic Publication: 2021 Jan 22.