Výsledky vyhledávání - "Kroum Alexandrov"

The critical DNA damage by benzo(a)pyrene in lung tissues of smokers and approaches to preventing its formation

Autor: Margarita Rojas, Soisungwan Satarug, Kroum Alexandrov

Publikováno v: Toxicology Letters. 198:63-68

Benzo(a)pyrene (BP) and cadmium are environmental pollutants found in foodstuffs, cigarette smoke, and polluted air. BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd3c6a8de9b8b4a082bf930bebfebef
https://doi.org/10.1016/j.toxlet.2010.04.009

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DNA Damage by Benzo(a)pyrene in Human Cells Is Increased by Cigarette Smoke and Decreased by a Filter Containing Rosemary Extract, Which Lowers Free Radicals

Autor: Margarita Rojas, Christian Rolando, Kroum Alexandrov

Publikováno v: Cancer Research. 66:11938-11945

We found previously that the human lung benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide-N2-deoxyguanosine (BPDE-dG) adduct concentrate in the target bronchial cells. This adduct is now considered to be critical event in tumorigenesis by BP. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b0bccfcec37f1b8b2f0501af0b5264
https://doi.org/10.1158/0008-5472.can-06-3277

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CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation

Autor: Ingolf Cascorbi, Guy Bouvier, E. Kriek, Kroum Alexandrov, Helmut Bartsch, Margarita Rojas

Publikováno v: Carcinogenesis. 23:1969-1977

Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8f8bc17782cc3ddef3529029fdac3e
https://doi.org/10.1093/carcin/23.12.1969

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Myeloperoxidase--463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients

Autor: Ingolf Cascorbi, Frederik-Jan van Schooten, Roger W. L. Godschalk, E. Kriek, Margarita Rojas, Kroum Alexandrov, Judith Ostertag, Helmut Bartsch

Publikováno v: Carcinogenesis, 22, 1015-1018. Oxford University Press

Carcinogenesis 2001 Jul;22(7):1015-8 Related Articles, Books, LinkOut Myeloperoxidase--463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients.Rojas M, Godschalk R, Alexandrov K, Cascorbi I, Kriek E, Ostertag

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https://doi.org/10.1093/carcin/22.7.1015

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Genetic Cancer Susceptibility and DNA Adducts: Studies in Smokers, Tobacco Chewers, and Coke Oven Workers

Autor: Helmut Bartsch, Jagadeesan Nair, Kroum Alexandrov, Nair Uj, Margarita Rojas

Publikováno v: Cancer Detection Prevention. 23:445-453

Preventive strategies require identification of cancer-susceptible individuals resulting from combinations of carcinogen exposure, cancer-predisposing genes, and lack of protective factors. To this aim, related to tobacco smoking and chewing (betel q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b031d5586bae79a5da10f2ef8a8bfc45
https://doi.org/10.1046/j.1525-1500.1999.99055.x

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Polycyclic aromatic hydrocarbon-DNA adducts in humans: relevance as biomarkers for exposure and cancer risk

Autor: Kroum Alexandrov, Margarita Rojas, Helmut Bartsch, Erik Kriek

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 400:215-231

The methodology applied for DNA adducts in humans has become more reliable in recent years, allowing to detect even background carcinogenic adduct levels in environmentally exposed persons. Particularly, combinations of the various methods now allow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4780b32a61ed85327f4d88d9e0463745
https://doi.org/10.1016/s0027-5107(98)00065-7

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Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans

Autor: Sisko Anttila, A.-M. Camus, Marcel Castegnaro, C. Malaveille, Helmut Bartsch, Eino Hietanen, Margarita Rojas, K Hirvonen, Kroum Alexandrov, Kirsti Husgafvel-Pursiainen

Publikováno v: Pharmacogenetics. 5:S84-S90

A case-control study on lung cancer patients demonstrated the pronounced effect of tobacco smoke on pulmonary carcinogen metabolism and suggested the existence of a metabolic phenotype at higher risk for tobacco-associated lung cancer. Lung cancer pa

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https://doi.org/10.1097/00008571-199512001-00007

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Anti-benzo[a]pyrene diolepoxide—DNA adduct levels in peripheral mononuclear cells from coke oven workers and the enhancing effect of smoking

Autor: Bernard Mahieu, Kroum Alexandrov, Margarita Rojas, Lucienne Mayer, Agnès Wastiaux-Denamur, Patrick Sebastien, Guy Auburtin, Helmut Bartsch

Publikováno v: Carcinogenesis. 16:1373-1376

The level of (+/-)-r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) bound to DNA of lymphocytes plus monocytes in 39 coke oven workers exposed to polycyclic aromatic hydrocarbons (PAH) and 39 non-exposed persons (controls) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350196818287d2286a6d2ab73b7804f9
https://doi.org/10.1093/carcin/16.6.1373

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