Carvedilol inhibits neuronal hyperexcitability caused by epilepsy-associated KCNT1 mutations.

Autor: Di C; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.; Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China., Wu T; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Gao K; Department of Pediatrics, Peking University First Hospital, Beijing, China.; Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases, Beijing, China.; Children Epilepsy Center, Peking University First Hospital, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, China., Li N; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Song H; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Wang L; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Sun H; UCL School of Pharmacy, University College London, London, UK., Yi J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Zhang X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Chen J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China., Shah M; UCL School of Pharmacy, University College London, London, UK., Jiang Y; Department of Pediatrics, Peking University First Hospital, Beijing, China.; Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases, Beijing, China.; Children Epilepsy Center, Peking University First Hospital, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, China., Huang Z; State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.; IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Oct 06. Date of Electronic Publication: 2024 Oct 06.

Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon‐to‐Bone Healing: A Large Animal Study and Short‐Term Outcome of a Clinical Trial.

Autor: Kang, Yuhao^1,2, Wang, Liren^1,2, Zhang, Shihao³, Liu, Bowen⁴, Gao, Haihan^1,2, Jin, Haocheng^1,2, Xiao, Lan⁵, Zhang, Guoyang^1,2, Li, Yulin³ yulinli@ecust.edu.cn, Jiang, Jia^1,2 jessicajj19@hotmail.com, Zhao, Jinzhong^1,2 jzzhao@sjtu.edu.cn

Publikováno v: Advanced Science. 8/21/2024, Vol. 11 Issue 31, p1-17. 17p.

Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice.

Autor: Luque MA; Departamento Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain., Morcuende S; Departamento Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain., Torres B; Departamento Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain., Herrero L; Departamento Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain.

Publikováno v: The Journal of physiology [J Physiol] 2024 Aug; Vol. 602 (15), pp. 3769-3791. Date of Electronic Publication: 2024 Jul 08.

KCNT1 Channel Blockers: A Medicinal Chemistry Perspective.

Autor: Di Matteo, Francesca¹ (AUTHOR) rturcio@unisa.it, Mancuso, Francesca² (AUTHOR), Turcio, Rita¹ (AUTHOR) tciaglia@unisa.it, Ciaglia, Tania¹ (AUTHOR), Stagno, Claudio² (AUTHOR), Di Chio, Carla² (AUTHOR), Campiglia, Pietro¹ (AUTHOR), Bertamino, Alessia¹ (AUTHOR), Giofrè, Salvatore Vincenzo² (AUTHOR), Ostacolo, Carmine¹ (AUTHOR) costacolo@unisa.it, Iraci, Nunzio² (AUTHOR) costacolo@unisa.it

Publikováno v: Molecules. Jun2024, Vol. 29 Issue 12, p2940. 18p.

Pore-Lining Residues Identified by Single Channel SCAM Studies in Cx46 Hemichannels.

Autor: Kronengold, J., Trexler, E. B., Bargiello, T. A., Bukauskas, F. F., Verselis, V. K.

Publikováno v: Cell Communication & Adhesion; Jul-Dec2003, Vol. 10 Issue 4-6, p193-199, 7p, 2 Diagrams, 2 Graphs