Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach

Autor: Krohl, Patrick J., Fine, Justyn, Yang, Huilin, VanDyke, Derek, Ang, Zhiwei, Kim, Kook Bum, Thomas-Tikhonenko, Andrei, Spangler, Jamie B.

Publikováno v: In Cell Reports Methods 27 March 2023 3(3)

A Hybrid Adherent/Suspension Cell-Based Selection Strategy for Discovery of Antibodies Targeting Membrane Proteins

Autor: Krohl, Patrick J., Spangler, Jamie B.

Publikováno v: Methods in Molecular Biology ISBN: 9781071622841
Methods Mol Biol

Membrane proteins are favored drug targets and antibody therapeutics represent the fastest-growing category of pharmaceuticals. However, there remains a need for rapid and effective approaches for the discovery of antibodies that recognize membrane p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c74e65443c07d19e40b6f59dc857cc
https://doi.org/10.1007/978-1-0716-2285-8_11

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Function-first discovery of high affinity monoclonal antibodies using Nanovial-based plasma B cell screening.

Autor: Challa D; Alloy Therapeutics., de Rutte J; Partillion Bioscience Corporation., Konu C; Alloy Therapeutics., Udani S; Partillion Bioscience Corporation., Liang J; Partillion Bioscience Corporation., Krohl PJ; Alloy Therapeutics., Rondon R; Partillion Bioscience Corporation., Bondensgaard K; Alloy Therapeutics., Di Carlo D; Partillion Bioscience Corporation.; University of California, Los Angeles., Watkins-Yoon J; Alloy Therapeutics.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 19. Date of Electronic Publication: 2024 Aug 19.