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Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update

Autor: Martin, MA, Hoffman, JM, Freimuth, RR, Klein, TE, Dong, BJ, Pirmohamed, M, Hicks, JK, Wilkinson, MR, Haas, DW, Kroetz, DL, Clinical Pharmacogenetics Implementation Consortium

Publikováno v: Clinical pharmacology and therapeutics, vol 95, iss 5

The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for HLA-B Genotype and Abacavir Dosing were originally published in April 2012. We reviewed recent literature and concluded that none of the evidence would change the therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3e7f03a2cd859704773ea74c0d8f2d35
https://escholarship.org/uc/item/7ts1562x

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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance)

Autor: Chhibber, A, Mefford, J, Stahl, EA, Pendergrass, SA, Baldwin, RM, Owzar, K, Li, M, Winer, EP, Hudis, CA, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, HL, Ratain, MJ, Shulman, LN, Ritchie, MD, Plenge, RM, Witte, JS, Kroetz, DL

Publikováno v: Pharmacogenomics Journal, vol 14, iss 4

Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peripheral neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e70e960aba4b968132671fec06d80631
https://escholarship.org/uc/item/53n789q6

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Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression

Autor: Kroetz, Deanna, Nguyen, TD, Markova, S, Liu, W, Gow, JM, Baldwin, RM, Habashian, M, Relling, MV, Ratain, MJ, Kroetz, DL

Publikováno v: Kroetz, Deanna; Nguyen, TD; Markova, S; Liu, W; Gow, JM; Baldwin, RM; et al.(2013). Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/58q905j9

Multidrug resistance protein 2 (MRP2, ABCC2) is an efflux membrane transporter highly expressed in liver, kidney and intestine with important physiological and pharmacological roles. The goal of this study was to investigate the functional significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::70af2aebb4eb16d979ab0497d6d6996b
http://www.escholarship.org/uc/item/58q905j9

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Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping

Autor: Giacomini, Kathleen, Kroetz, Deanna, Matsson, P, Yee, SW, Markova, S, Morrissey, K, Jenkins, G, Xuan, J, Jorgenson, E, Kroetz, DL, Giacomini, KM

Publikováno v: Giacomini, Kathleen; Kroetz, Deanna; Matsson, P; Yee, SW; Markova, S; Morrissey, K; et al.(2012). Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5d475641

ATP-binding cassette (ABC) membrane transporters determine the disposition of many drugs, metabolites and endogenous compounds. Coding region variation in ABC transporters is the cause of many genetic disorders, but much less is known about the genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::0f56c0a958b5ba227f96a4c6ece6691e
http://www.escholarship.org/uc/item/5d475641

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Akademický článek

Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.

Autor: Yee, SW, Giacomini, MM, Hsueh, C‐H, Weitz, D, Liang, X, Goswami, S, Kinchen, JM, Coelho, A, Zur, AA, Mertsch, K, Brian, W, Kroetz, DL, Giacomini, KM

Publikováno v: Clinical Pharmacology & Therapeutics; Nov2016, Vol. 100 Issue 5, p524-536, 13p

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Akademický článek

Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy.

Autor: Chua, KC, Kroetz, DL

Publikováno v: Clinical Pharmacology & Therapeutics; Apr2017, Vol. 101 Issue 4, p450-452, 3p

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