Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjogren's Syndrome

Autor: Verstappen, GM, Meiners, PM, Corneth, Odilia, Visser, A, Arends, S, Abdulahad, WH, Hendriks, Rudi, Vissink, A, Kroese, FGM, Bootsma, H

Publikováno v: Arthritis & Rheumatology, 69(9), 1850-1861. Wiley
ARTHRITIS & RHEUMATOLOGY, 69(9), 1850-1861. John Wiley & Sons Ltd.

Objective. To assess the effect of abatacept (CTLA-4Ig), which limits T cell activation, on homeostasis of CD4+ T cell subsets and T cell-dependent B cell hyperactivity in patients with primary Sjogren's syndrome (SS). Methods. Fifteen patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ad316bec3531fd211c911c7250a88edf
https://research.rug.nl/en/publications/e17cf786-e827-47fd-8371-d315813bfd72

Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjogren's Syndrome

Autor: Maria, NI, Van Helden - Meeuwsen, Corine, Brkic, Zana, Paulissen, Sandra, Steenwijk, Eline, Dalm, V.A.S.H., van Daele, Paul, van Hagen, P.M., Kroese, FGM, van Roon, JAG, Harkin, A, Dik, Wim, Drexhage, Hemmo, Lubberts, Erik, Versnel, Marjan

Publikováno v: ARTHRITIS & RHEUMATOLOGY, 68(7), 1688-1699. John Wiley & Sons Ltd.

Objective. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme that converts tryptophan to kynurenine, is driven in part by type I and type II interferons (IFNs). Naive T cells are polarized into FoxP31 Treg cells upon exposure to either IDO1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::3a0029bc73069f78bb9e0eaa3ad51db0
https://pure.eur.nl/en/publications/1ca4da47-3e24-4faf-a91e-b8c1eca89077

Vorming en expressie van antigeenreceptoren op T- en B-lymfocyten

Autor: Dongen, Jacques, Langerak, Ton, Kroese, FGM, Rijkers, GT, Kallenberg, CGM, Derksen, RHWM

Publikováno v: Immunologie, 69-93
STARTPAGE=69;ENDPAGE=93;TITLE=Immunologie
Leerboek immunologie, 103-126
STARTPAGE=103;ENDPAGE=126;TITLE=Leerboek immunologie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b1ca44724487f063212f51ee0387f41d
https://pure.eur.nl/en/publications/fa13e271-1804-4b52-a9d5-56a0aebb67fb

Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts

Autor: Stoel, M, Jiang, HQ, van Diemen, CC, Bun, JCAM, Dammers, PM, Thurnheer, MC, Kroese, FGM, Cebra, JJ, Bos, NA

Publikováno v: Journal of Immunology, 174(2), 1046-1054. AMER ASSOC IMMUNOLOGISTS

Mucosal IgA is the most abundantly produced Ig upon colonization of the intestinal tract with commensal organisms in the majority of mammals. The repertoire of these IgA molecules is still largely unknown; a large amount of the mucosal IgA cannot be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2295c7ec8c48314c4f8dcac1a9daf9e8
https://research.rug.nl/en/publications/018cf77b-fadf-4638-a8c7-89124baf9618

Most marginal zone B cells in rat express germline encoded Ig V-H genes and are ligand selected

Autor: Dammers, PM, Visser, A, Popa, ER, Nieuwenhuis, P, Kroese, FGM

Publikováno v: Journal of Immunology, 165(11), 6156-6169. AMER ASSOC IMMUNOLOGISTS

The present study was performed to analyze whether marginal zone B (MZ-B) cells in nondeliberately immunized adult rats are selected on basis of the specificity of their B cell receptor, and to determine to what extent memory B cells contribute to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::907314946eeecd8411d06d538339fe4d
https://research.rug.nl/en/publications/ee6fc8eb-40b9-4ab6-b768-127238f05bd6