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QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment

Autor: Bresser, Kaspar, Logtenberg, Meike E. W., Toebes, Mireille, Proost, Natalie, Sprengers, Justin, Siteur, Bjorn, Boeije, Manon, Kroese, Lona J., Schumacher, Ton N.

Publikováno v: ONCOIMMUNOLOGY, 11(1). TAYLOR & FRANCIS INC

The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties. A number of studies have implicated QPCTL in the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a23accac71b349389782b2471aa9e7b
https://hdl.handle.net/1887/3566485

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QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment.

Autor: Bresser K; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Logtenberg MEW; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Toebes M; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Proost N; Preclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Sprengers J; Preclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Siteur B; Preclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Boeije M; Preclinical Intervention Unit, Mouse Clinic for Cancer and Ageing, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Kroese LJ; Transgenic Facility, Mouse Clinic for Cancer and Aging Research, the Netherlands Cancer Institute, Amsterdam, The Netherlands., Schumacher TN; Division of Molecular Oncology & Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Oncoimmunology [Oncoimmunology] 2022 Mar 17; Vol. 11 (1), pp. 2049486. Date of Electronic Publication: 2022 Mar 17 (Print Publication: 2022).