Can toxicokinetics of (synthetic) cannabinoids in pigs after pulmonary administration be upscaled to humans by allometric techniques?

Autor: Schaefer N; Institute of Legal Medicine, Saarland University, Building 80.2, D-66421 Homburg, Saar, Germany. Electronic address: nadine.schaefer@uks.eu., Wojtyniak JG; Clinical Pharmacy, Saarland University, D-66123 Saarbruecken, Germany., Kroell AK; Institute of Legal Medicine, Saarland University, Building 80.2, D-66421 Homburg, Saar, Germany., Koerbel C; Institute for Clinical & Experimental Surgery, Saarland University, Building 65/66, D-66421 Homburg, Saar, Germany., Laschke MW; Institute for Clinical & Experimental Surgery, Saarland University, Building 65/66, D-66421 Homburg, Saar, Germany., Lehr T; Clinical Pharmacy, Saarland University, D-66123 Saarbruecken, Germany., Menger MD; Institute for Clinical & Experimental Surgery, Saarland University, Building 65/66, D-66421 Homburg, Saar, Germany., Maurer HH; Department of Experimental and Clinical Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Building 46, D-66421 Homburg, Saar, Germany., Meyer MR; Department of Experimental and Clinical Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Building 46, D-66421 Homburg, Saar, Germany., Schmidt PH; Institute of Legal Medicine, Saarland University, Building 80.2, D-66421 Homburg, Saar, Germany.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2018 Sep; Vol. 155, pp. 403-418. Date of Electronic Publication: 2018 Jul 24.