Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs.

Autor: Krivinko JM; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fan P; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Sui Z; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Happe C; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hensler C; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Gilardi J; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ikonomovic MD; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., McKinney BC; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Newman J; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ding Y; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Wang L; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Sweet RA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. SweetRA@upmc.edu.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. SweetRA@upmc.edu., MacDonald ML; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.

Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease.

Autor: Krivinko JM; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., DeChellis-Marks MR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zeng L; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Fan P; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Lopez OL; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ding Y; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Wang L; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screening Center, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Kofler J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., MacDonald ML; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sweet RA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. sweetra@upmc.edu.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. sweetra@upmc.edu.

Publikováno v: Communications biology [Commun Biol] 2023 Jun 02; Vol. 6 (1), pp. 598. Date of Electronic Publication: 2023 Jun 02.

Psychosis in Alzheimer's Disease Is Associated With Increased Excitatory Neuron Vulnerability and Post-transcriptional Mechanisms Altering Synaptic Protein Levels.

Autor: DeChellis-Marks MR; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Wei Y; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States., Ding Y; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States., Wolfe CM; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States., Krivinko JM; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., MacDonald ML; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Lopez OL; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Sweet RA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Kofler J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Publikováno v: Frontiers in neurology [Front Neurol] 2022 Mar 02; Vol. 13, pp. 778419. Date of Electronic Publication: 2022 Mar 02 (Print Publication: 2022).

Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

Autor: Krivinko JM; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Erickson SL; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Ding Y; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Sun Z; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Penzes P; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., MacDonald ML; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Yates NA; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Ikonomovic MD; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Lopez OL; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Sweet RA; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh., Kofler J; From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh.

Publikováno v: The American journal of psychiatry [Am J Psychiatry] 2018 Oct 01; Vol. 175 (10), pp. 999-1009. Date of Electronic Publication: 2018 Jul 19.