Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kriti Modi"'
Publikováno v:
Tetrahedron Letters. 50:1571-1574
Herein, we describe the synthesis of the novel 4-(1H-benzo[d]imidazol-2-yl)isoxazol-5-amine (7) and 4-(1H-benzo[d]thiazol-2-yl)isoxazol-5-amine scaffolds (8). Initial attempts following literature procedures for the synthesis of similar compounds did
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d4968111549d3b9eba8693a75766ab
https://doi.org/10.1016/j.tetlet.2009.01.085
https://doi.org/10.1016/j.tetlet.2009.01.085
Autor:
Mei-Chu Lo, Ji Ma, Julio C. Medina, Dineli Wickramasinghe, Mark L. Ragains, Derek E. Piper, Merrill Ayres, Zhihong Li, Alex J. Zhang, Xiaoqi Chen, Jeffrey Deignan, Zhulun Wang, Kanaka Pattabiraman, Kathleen S. Keegan, Xiaoning Zhao, Rachel Ngo, Nigel Walker, Lingming Liang, Margaret F. Weidner, Paul M. Wehn, Christophe Queva, Jason Duquette, Alexander Kamb, Ada Chen, Malgorzata Wanska, Jeffrey T. Mihalic, Kriti Modi, Pingchen Fan, Grace Q. Alba, Yunxiao Li, Michael W. Gribble, John Eksterowicz, Jacob Kaizerman, Dustin McMinn, Xianghong Wang, Michael DeGraffenreid, Steve Thibault, Xiaodong Wang, Kexue Li, Benjamin Fisher, Richard V. Connors, Wen Liu, Sarah E. Lively, Cong Li, Kang Dai, Jiasheng Fu, Justin N. Huard, Robert Cho, Lawrence R. McGee, Timothy J. Carlson, Julia Suchomel
Publikováno v:
Journal of medicinal chemistry. 57(8)
We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using cell-based assays,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5055c042d7a9cff8f5682847cec87995
https://pubmed.ncbi.nlm.nih.gov/24641103
https://pubmed.ncbi.nlm.nih.gov/24641103
Publikováno v:
ChemInform. 40
Herein, we describe the synthesis of the novel 4-(1H-benzo[d]imidazol-2-yl)isoxazol-5-amine (7) and 4-(1H-benzo[d]thiazol-2-yl)isoxazol-5-amine scaffolds (8). Initial attempts following literature procedures for the synthesis of similar compounds did
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5e263ea3163d08f8f371d8e6e41319
https://doi.org/10.1002/chin.200929123
https://doi.org/10.1002/chin.200929123
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fced7d40c539af3aa06976a2a089ecd
https://doi.org/10.1002/chin.200702067
https://doi.org/10.1002/chin.200702067
Publikováno v:
Angewandte Chemie International Edition; Sep2006, Vol. 45 Issue 37, p6130-6133, 4p