Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Krithika, Lingappan"'
Autor:
Connor Leek, Abiud Cantu, Shilpa Sonti, Manuel Cantu Gutierrez, Laurie Eldredge, Eniko Sajti, He N. Xu, Krithika Lingappan
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103296- (2024)
The lung macrophages play a crucial role in health and disease. Sexual dimorphism significantly impacts the phenotype and function of tissue-resident macrophages. The primary mechanisms responsible for sexually dimorphic outcomes in bronchopulmonary
Externí odkaz:
https://doaj.org/article/61d7856613d346e6afb2dbc5bfa6ac0b
Autor:
Sandra L. Grimm, Samuel Reddick, Xiaoyu Dong, Connor Leek, Amy Xiao Wang, Manuel Cantu Gutierrez, Sean M. Hartig, Bhagavatula Moorthy, Cristian Coarfa, Krithika Lingappan
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Bronchopulmonary dysplasia (BPD) is characterized by an arrest in lung development and is a leading cause of morbidity in premature neonates. It has been well documented that BPD disproportionally affects males compared to females
Externí odkaz:
https://doaj.org/article/b08c6f1bdb5049889cfae7c8a2b0788f
Autor:
Abiud Cantu, Manuel Cantu Gutierrez, Xiaoyu Dong, Connor Leek, Montserrat Anguera, Krithika Lingappan
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102933- (2023)
Recovery from lung injury during the neonatal period requires the orchestration of many biological pathways. The modulation of such pathways can drive the developing lung towards proper repair or persistent maldevelopment that can lead to a disease p
Externí odkaz:
https://doaj.org/article/30374b43c768492ba4fc9d6462e48c6d
Autor:
Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102790- (2023)
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. Murine studies showed that C
Externí odkaz:
https://doaj.org/article/dab80afae43644dcbeba12aeb3c31668
Autor:
Oluyinka O. Olutoye II, Walker D. Short, Jamie Gilley, J. D. Hammond II, Michael A. Belfort, Timothy C. Lee, Alice King, Jimmy Espinoza, Luc Joyeux, Krithika Lingappan, Jason P. Gleghorn, Sundeep G. Keswani
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Congenital diaphragmatic hernia (CDH) is a complex disease associated with pulmonary hypoplasia and pulmonary hypertension. Great strides have been made in our ability to care for CDH patients, specifically in the prenatal improvement of lung volume
Externí odkaz:
https://doaj.org/article/f3e4f355d8364582a2647dc7387b32b0
Autor:
Parag N. Jain, Matthew Robertson, Javier J. Lasa, Lara Shekerdemian, Danielle Guffey, Yuhao Zhang, Krithika Lingappan, Paul Checchia, Cristian Coarfa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The study examines the whole blood transcriptome profile before and after cardiopulmonary bypass (CPB) in neonates with hypoplastic left heart syndrome (HLHS), a severe form of congenital heart disease, that can develop low cardiac output sy
Externí odkaz:
https://doaj.org/article/fbdabfac3e974381be86352f0fae6c19
Autor:
Sandra L. Grimm, Xiaoyu Dong, Yuhao Zhang, Alexandre F. Carisey, Arthur P. Arnold, Bhagavatula Moorthy, Cristian Coarfa, Krithika Lingappan
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
The main mechanisms underlying sexually dimorphic outcomes in neonatal lung injury are unknown. We tested the hypothesis that hormone- or sex chromosome–mediated mechanisms interact with hyperoxia exposure to impact injury and repair in the neonata
Externí odkaz:
https://doaj.org/article/56eacf2b7a3549de8747cf0456bb730d
Publikováno v:
The Journal of Pediatrics. 255:17-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e73108b042c1627c0c5909e78fa7f0
https://doi.org/10.1016/j.jpeds.2022.11.021
https://doi.org/10.1016/j.jpeds.2022.11.021
Autor:
Brielle Hayward-Piatkovskyi, Cailin R. Gonyea, Sienna C. Pyle, Krithika Lingappan, Jason P. Gleghorn
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H26-H32
Bronchopulmonary dysplasia (BPD) is a disease with a significant sexual dimorphism where males have a disadvantage compared with their female counterparts. Although mechanisms behind this sexual dimorphism are poorly understood, sex differences in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9150944643ce1c968f11c7863a26d9d7
https://doi.org/10.1152/ajpheart.00552.2022
https://doi.org/10.1152/ajpheart.00552.2022
Autor:
Faeq Al-Mudares, Samuel Reddick, Jenny Ren, Akshaya Venkatesh, Candi Zhao, Krithika Lingappan
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Growth Differentiation Factor 15 (GDF15) is a divergent member of transforming growth factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological conditions. GDF15 expression increases during many pathological states an
Externí odkaz:
https://doaj.org/article/534d23d5abed4024ade34161433ad532