Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Krisztina Zsebo"'
Autor:
Lingfeng, Qin, Bo, Jiang, Krisztina, Zsebo, Henricus J, Duckers, Michael, Simons, Pei-Yu, Chen
Publikováno v:
Journal of Visualized Experiments.
Pulmonary arterial hypertension (PAH) is a progressive life-threatening disease, primarily affecting small pulmonary arterioles of the lung. Currently, there is no cure for PAH. It is important to discover new compounds that can be used to treat PAH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576b98812e534a5697a0d9d4e9503a4e
https://doi.org/10.3791/63839
https://doi.org/10.3791/63839
Autor:
S Welch, Sian E. Harding, Jayan Parameshwar, Nicholas Johnson, H-Y Yang, Clive Lewis, M. Hedger, Thiagarajah Sasikaran, Kenneth T. MacLeod, A Suarez Barrientos, Krisztina Zsebo, Emanuela Falaschetti, J J Rudy, Daphne Babalis, Nicholas R. Banner, Alexander R. Lyon, S. Rahman Haley, Steven Tsui, E A Rog-Zielinska, Alexandra Rice, Gabor Foldes, John Pepper, Rasheda A. Chowdhury, Cesare M. Terracciano, Roger J. Hajjar, Konstantinos N. Tzortzis, Nicholas S. Peters, Liam Couch, Andrew Morley-Smith, Christopher Bowles, A R Bell, A. Simon
Publikováno v:
Gene Therapy
The SERCA-LVAD trial was a phase 2a trial assessing the safety and feasibility of delivering an adeno-associated vector 1 carrying the cardiac isoform of the sarcoplasmic reticulum calcium ATPase (AAV1/SERCA2a) to adult chronic heart failure patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1730d922152ce8fd3fe707c1c1cc7c
http://hdl.handle.net/10044/1/78835
http://hdl.handle.net/10044/1/78835
Autor:
Lahouaria Hadri, Kenneth Fish, Ahyoung Lee, Bradley A. Maron, Maria Plataki, Kiyotake Ishikawa, Erik Kohlbrenner, Changwon Kho, Nadjib Hammoudi, Valentin Fuster, Jane A. Leopold, Jaume Aguero, Ana García-Álvarez, Borja Ibanez, Carlos G. Santos-Gallego, Krisztina Zsebo, Roger J. Hajjar
Publikováno v:
Journal of the American College of Cardiology. 67:2032-2046
Background: Pulmonary hypertension (PH) is characterized by pulmonary arterial remodeling that results in increased pulmonary vascular resistance, right ventricular (RV) failure, and premat...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::103f42b269563b54d437d1eb6a892fdd
https://doi.org/10.1016/j.jacc.2016.02.049
https://doi.org/10.1016/j.jacc.2016.02.049
Autor:
Daniel G. Anderson, Krisztina Zsebo, Kiyotake Ishikawa, Dongtak Jeong, Kenneth Fish, Changwon Kho, Jaume Aguero, Kevin D. Costa, Lauren Fish, Lifan Liang, Lisa Tilemann, Roger J. Hajjar, Elisa Yaniz-Galende, Ahmed A. Eltoukhy
Publikováno v:
PMC
Background—Stem cell factor (SCF), a ligand of the c-kit receptor, is a critical cytokine, which contributes to cell migration, proliferation, and survival. It has been shown that SCF expression increases after myocardial infarction (MI) and may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b004dfd4ed49ab721f52e923ad69de
https://doi.org/10.1161/circheartfailure.114.001711
https://doi.org/10.1161/circheartfailure.114.001711
Autor:
Javed Butler, Adriaan A. Voors, G. Michael Felker, Alex Yaroshinsky, Roger J. Hajjar, Barry H. Greenberg, Kim Wagner, Jeffrey J. Rudy, Krisztina Zsebo
Publikováno v:
JACC: Heart Failure. 2:84-92
Objectives Impaired cardiac isoform of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity is a key abnormality in heart failure patients with reduced ejection fraction. The CUPID 2 (Calcium Up-Regulation by Percutaneous Administration of Gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f055b64a2b7861c605829f693f70b3a2
https://doi.org/10.1016/j.jchf.2013.09.008
https://doi.org/10.1016/j.jchf.2013.09.008
Autor:
Gregory D. Gillispie, Russell Dahl, Ji Li, David D. Thomas, Simon J. Gruber, Seth L. Robia, Kurt C. Peterson, Tory M. Schaaf, Krisztina Zsebo, Razvan L. Cornea
Publikováno v:
SLAS Discovery. 19:215-222
We have used a "two-color" SERCA (sarco/endoplasmic reticulum calcium ATPase) biosensor and a unique high-throughput fluorescence lifetime plate reader (FLT-PR) to develop a high-precision live-cell assay designed to screen for small molecules that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92559d7461b57160966f2afcd915ad27
https://doi.org/10.1177/1087057113510740
https://doi.org/10.1177/1087057113510740
Autor:
Lifan Liang, Jane A. Leopold, Ludovic Benard, Lahouaria Hadri, Yoshiaki Kawase, Marc Humbert, Bradley A. Maron, Erik Kohlbrenner, Razmig Garo Kratlian, Krisztina Zsebo, Kiyotake Ishikawa, Peter Dorfmüller, Christophe Guignabert, Irene C. Turnbull, Roger J. Hajjar, Jean-Sébastien Hulot, Dennis Ladage, Borja Ibanez, Jaume Aguero
Publikováno v:
Circulation. 128:512-523
Background— Pulmonary arterial hypertension (PAH) is characterized by dysregulated proliferation of pulmonary artery smooth muscle cells leading to (mal)adaptive vascular remodeling. In the systemic circulation, vascular injury is associated with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991ec4f25a2bcc787bc9bd0d78796219
https://doi.org/10.1161/circulationaha.113.001585
https://doi.org/10.1161/circulationaha.113.001585
Autor:
Joseph M. Muretta, Gregory D. Gillispie, Razvan L. Cornea, Russell Dahl, David D. Thomas, Elizabeth L. Lockamy, Simon J. Gruber, Krisztina Zsebo, Jiqiu Chen, Dongzhu Jin, Tamas Bartfai
Publikováno v:
SLAS Discovery. 18:97-107
Using fluorescence resonance energy transfer (FRET), we performed a high-throughput screen (HTS) in a reconstituted membrane system, seeking compounds that reverse inhibition of sarco-/endoplasmic reticulum Ca-ATPase (SERCA) by its endogenous regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d36f7d650c644d002126ce2e7c39713
https://doi.org/10.1177/1087057112456878
https://doi.org/10.1177/1087057112456878
Autor:
Janice M. Pogoda, J Guerrero, R Provost, Javed Butler, G.M. Felker, Barry H. Greenberg, A. A. Voors, Piotr Ponikowski, Krisztina Zsebo, Roger J. Hajjar
Publikováno v:
Gene therapy, vol 23, iss 3
Adeno-associated virus serotype 1 (AAV1) has many advantages as a gene therapy vector, but the presence of pre-existing neutralizing antibodies (NAbs) is an important limitation. This study was designed to determine: (1) characteristics of AAV NAbs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b43c5410e95794f7cb05b03be006a0
https://escholarship.org/uc/item/3981f97z
https://escholarship.org/uc/item/3981f97z
Autor:
Jaume, Aguero, Kiyotake, Ishikawa, Lahouaria, Hadri, Carlos G, Santos-Gallego, Kenneth M, Fish, Erik, Kohlbrenner, Nadjib, Hammoudi, Changwon, Kho, Ahyoung, Lee, Borja, Ibáñez, Ana, García-Alvarez, Krisztina, Zsebo, Bradley A, Maron, Maria, Plataki, Valentin, Fuster, Jane A, Leopold, Roger J, Hajjar
Publikováno v:
Journal of the American College of Cardiology. 67(17)
Pulmonary hypertension (PH) is characterized by pulmonary arterial remodeling that results in increased pulmonary vascular resistance, right ventricular (RV) failure, and premature death. Down-regulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f4db727c52ece96c93d90b83fd56d05
https://pubmed.ncbi.nlm.nih.gov/27126532
https://pubmed.ncbi.nlm.nih.gov/27126532