Výsledky vyhledávání - "Krisztián Fodor"

Akademický článek

Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.

Autor: Krisztián Fodor, Janina Wolf, Ralf Erdmann, Wolfgang Schliebs, Matthias Wilmanns

Publikováno v: PLoS Biology, Vol 10, Iss 4, p e1001309 (2012)

Alanine-glyoxylate aminotransferase is a peroxisomal enzyme, of which various missense mutations lead to irreversible kidney damage via primary hyperoxaluria type 1, in part caused by improper peroxisomal targeting. To unravel the molecular mechanism

Externí odkaz: https://doaj.org/article/e561a6a26244485a86ae31caa0e6323b

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Correction: Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation

Autor: Zoltán Attila Nagy, Dávid Héja, Dániel Bencze, Bence Kiss, Eszter Boros, Dávid Szakács, Krisztián Fodor, Matthias Wilmanns, Andrea Kocsis, József Dobó, Péter Gál, Veronika Harmat, Gábor Pál

Publikováno v: J Biol Chem

Ecotin is a homodimeric serine protease inhibitor produced by many commensal and pathogenic microbes. It functions as a virulence factor, enabling survival of various pathogens in the blood. The ecotin dimer binds two protease molecules, and each eco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7761d6ddd3bf8b8fad27c9d367ca5b54
https://europepmc.org/articles/PMC9800290/

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Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation

Publikováno v: The Journal of biological chemistry. 298(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5762d6c85371504b3570b23b4adc5c6
https://pubmed.ncbi.nlm.nih.gov/35483450

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Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes

Autor: Ralf Erdmann, Wolfgang Schliebs, Katharina Reglinski, Ye Lou, Krisztián Fodor, Janina Wolf, Matthias Wilmanns, Daniel M. Passon

Publikováno v: Traffic. 16:85-98

Peroxisomes entirely rely on the import of their proteome across the peroxisomal membrane. Recognition efficiencies of peroxisomal proteins vary by more than 1000-fold, but the molecular rationale behind their subsequent differential import and sorti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0b1f53bbf5c43cee7edc7327f234fc
https://doi.org/10.1111/tra.12238

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Protein translocation into peroxisomes by ring-shaped import receptors

Autor: Marc A. Marti-Renom, Wolfgang Schliebs, Will A. Stanley, Krisztián Fodor, Matthias Wilmanns

Publikováno v: FEBS Letters. 581:4795-4802

Folded and functional proteins destined for translocation from the cytosol into the peroxisomal matrix are recognized by two different peroxisomal import receptors, Pex5p and Pex7p. Both cargo-loaded receptors dock on the same translocon components,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9619a0f81e1418a510e59b07d706e6a
https://doi.org/10.1016/j.febslet.2007.09.001

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Structural Insights into Cargo Recognition by the Yeast PTS1 Receptor*

Autor: Daniel M. Passon, Wolfgang Schliebs, Krisztián Fodor, Matthias Wilmanns, Harald W. Platta, Stefanie Hagen, Friedel Drepper, Sven Fischer, Michael Zenn, Bettina Warscheid, Wolfgang Girzalsky, Ralf Erdmann

The peroxisomal matrix protein import is facilitated by cycling import receptors that shuttle between the cytosol and the peroxisomal membrane. The import receptor Pex5p mediates the import of proteins harboring a peroxisomal targeting signal of type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b0083d9dbdc9f5a45bc5dae17bf04f
https://europepmc.org/articles/PMC4646318/

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Extended Intermolecular Interactions in a Serine Protease–Canonical Inhibitor Complex Account for Strong and Highly Specific Inhibition

Autor: László Gráf, Gergely Katona, József Kardos, András Perczel, Csaba Hetényi, József Antal, Veronika Harmat, Krisztián Fodor, András Patthy

Publikováno v: Journal of Molecular Biology. 350:156-169

We have previously shown that a trypsin inhibitor from desert locust Schistocerca gregaria (SGTI) is a taxon-specific inhibitor that inhibits arthropod trypsins, such as crayfish trypsin, five orders of magnitude more effectively than mammalian tryps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54384381324529b21e390c30a64d64
https://doi.org/10.1016/j.jmb.2005.04.039

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Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region

Autor: Skander Elleuche, Amélie von der Heyde, Matthias Wilmanns, Barbara Klippel, Krisztián Fodor, Garabed Antranikian

Publikováno v: Applied microbiology and biotechnology. 98(9)

NAD(P)(+)-dependent alcohol dehydrogenases (ADH) are widely distributed in all phyla. These proteins can be assigned to three nonhomologous groups of isozymes, with group III being highly diverse with regards to catalytic activity and primary structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3704ba8245e8da6ec5876b954e649ea0
https://pubmed.ncbi.nlm.nih.gov/24265029

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