Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Kristyn Mccoy"'
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Akademický článek
Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design
Autor: Jo Lynne Rokita, Komal S. Rathi, Maria F. Cardenas, Kristen A. Upton, Joy Jayaseelan, Katherine L. Cross, Jacob Pfeil, Laura E. Egolf, Gregory P. Way, Alvin Farrel, Nathan M. Kendsersky, Khushbu Patel, Krutika S. Gaonkar, Apexa Modi, Esther R. Berko, Gonzalo Lopez, Zalman Vaksman, Chelsea Mayoh, Jonas Nance, Kristyn McCoy, Michelle Haber, Kathryn Evans, Hannah McCalmont, Katerina Bendak, Julia W. Böhm, Glenn M. Marshall, Vanessa Tyrrell, Karthik Kalletla, Frank K. Braun, Lin Qi, Yunchen Du, Huiyuan Zhang, Holly B. Lindsay, Sibo Zhao, Jack Shu, Patricia Baxter, Christopher Morton, Dias Kurmashev, Siyuan Zheng, Yidong Chen, Jay Bowen, Anthony C. Bryan, Kristen M. Leraas, Sara E. Coppens, HarshaVardhan Doddapaneni, Zeineen Momin, Wendong Zhang, Gregory I. Sacks, Lori S. Hart, Kateryna Krytska, Yael P. Mosse, Gregory J. Gatto, Yolanda Sanchez, Casey S. Greene, Sharon J. Diskin, Olena Morozova Vaske, David Haussler, Julie M. Gastier-Foster, E. Anders Kolb, Richard Gorlick, Xiao-Nan Li, C. Patrick Reynolds, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock, Pichai Raman, David A. Wheeler, John M. Maris
Publikováno v: Cell Reports, Vol 29, Iss 6, Pp 1675-1689.e9 (2019)
Summary: Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and li
Externí odkaz: https://doaj.org/article/5a7054ef48fe4832b69df7b358c3a0d5
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2
Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function
Autor: Shawn J. Macha, Balakrishna Koneru, Trevor A. Burrow, Charles Zhu, Dzmitry Savitski, Rakhshanda L. Rahman, Catherine A. Ronaghan, Jonas Nance, Kristyn McCoy, Cody Eslinger, C. Patrick Reynolds
Publikováno v: Cancer Res
A subset of cancers across multiple histologies with predominantly poor outcomes use the alternative lengthening of telomeres (ALT) mechanism to maintain telomere length, which can be identified with robust biomarkers. ALT has been reported to be pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c55c1f957315eda79e5b4291fa246f
https://doi.org/10.1158/0008-5472.can-22-0125
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Data from Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function
Autor: C. Patrick Reynolds, Cody Eslinger, Kristyn McCoy, Jonas Nance, Catherine A. Ronaghan, Rakhshanda L. Rahman, Dzmitry Savitski, Charles Zhu, Trevor A. Burrow, Balakrishna Koneru, Shawn J. Macha
A subset of cancers across multiple histologies with predominantly poor outcomes use the alternative lengthening of telomeres (ALT) mechanism to maintain telomere length, which can be identified with robust biomarkers. ALT has been reported to be pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4200c50bca1a444beeb1c5a5af1eba84
https://doi.org/10.1158/0008-5472.c.6514106.v1
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8
Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma
Autor: Thinh H. Nguyen, Shawn J. Macha, Sharon J. Diskin, Ahsan Farooqi, Gonzalo Lopez, Kristyn McCoy, Eduardo Urias, John M. Maris, Ashly Hindle, Balakrishna Koneru, Shengping Yang, Vanda Yazdani, Apexa Modi, David A. Wheeler, C. Patrick Reynolds, Meredith S. Irwin, Karina L. Conkrite, Jonas Nance, Jo Lynne Rokita, Heather L. Davidson
Publikováno v: Cancer Res
Neuroblastoma is a childhood cancer with heterogeneous clinical outcomes. To comprehensively assess the impact of telomere maintenance mechanism (TMM) on clinical outcomes in high-risk neuroblastoma, we integrated the C-circle assay [a marker for alt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e0dd72e60592a701657ec0a28fc8eb
https://doi.org/10.1158/0008-5472.can-19-3068
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9
Abstract 6228: APR-246, which restores p53 function, is highly active against alternative lengthening of telomere (ALT) cell lines and PDXs
Autor: Shawn J. Macha, Balakrishna Koneru, Trevor Burrow, Charles Zhu, Dzmitry Savitski, Jonas Nance, Kristyn McCoy, Cody Eslinger, C Patrick Reynolds
Publikováno v: Cancer Research. 82:6228-6228
Introduction: Most cancers proliferate by activating telomerase (TA+) while 10% of cancers utilize alternate lengthening of telomeres (ALT). ALT has been associated with resistance to DNA damaging agents, p53 loss-of-function (p53LOF), ATRX mutations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5f1260af961a7193f372dd2bb5bb360
https://doi.org/10.1158/1538-7445.am2022-6228
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10
Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial design
Autor: Pichai Raman, Richard B. Lock, Jacob Pfeil, Anthony C. Bryan, Gonzalo Lopez, Julia W. Böhm, Huiyuan Zhang, Siyuan Zheng, Gregory Gatto, Karthik Kalletla, Laura E. Ritenour, Sibo Zhao, Peter J. Houghton, Glenn M. Marshall, Frank K. Braun, Casey S. Greene, Sharon J. Diskin, Malcolm A. Smith, C. Patrick Reynolds, Khushbu Patel, Alvin Farrel, Gregory I. Sacks, Raushan T. Kurmasheva, Kristen M. Leraas, Zalman Vaksman, Katherine L. Cross, Yunchen Du, Zeineen Momin, Jonas Nance, Yolanda Sanchez, Holly Lindsay, Michelle Haber, Patricia Baxter, Yi Chen, Xiao-Nan Li, Apexa Modi, Katerina Bendak, Komal S. Rathi, Chelsea Mayoh, Kathryn L. Evans, Jack Shu, Lin Qi, Harshavardhan Doddapaneni, John M. Maris, Julie M. Gastier-Foster, Lori S. Hart, Kristen A. Upton, Maria F. Cardenas, Richard Gorlick, Gregory P. Way, Joy Jayaseelan, E. Anders Kolb, Jay Bowen, Olena Morozova Vaske, David A. Wheeler, Jo Lynne Rokita, Kateryna Krytska, Wendong Zhang, David Haussler, Vanessa Tyrrell, Dias Kurmashev, Yael P. Mosse, Christopher L. Morton, Sara E. Coppens, Nathan M. Kendsersky, Hannah McCalmont, Kristyn McCoy
SummaryAccelerating cures for children with cancer remains an immediate challenge due to extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6258e54ee3d309e6395d697f13771862
https://doi.org/10.1101/566455
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