Výsledky vyhledávání - "Kristy Potts"

Abstract 52: Analytical validation of the Resolution HRD plasma assay used to identify mCRPC patients with mutations, including homozygous deletions, in DNA repair genes as a companion diagnostic for niraparib

Autor: Julia Pollak, Kristy Potts, PuiYee Chan, Chen-Hsun Tsai, Angela Liao, Carly Garrison, Taylor Brown, Paul Stull, Zhen Li, Christine Baker, Kavita Garg, Ira Pekker, Michael Farabaugh, Michael Gormley, Lesley Farrington, Katherine Bell, Usha Singh

Publikováno v: Cancer Research. 82:52-52

Tumor cells of metastatic castration-resistant prostate cancer (mCRPC) patients with homologous recombination deficiency (HRD) are highly sensitive to the blockade of DNA single-strand break repair via the inhibition of the poly(adenosine diphosphate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb4cee0caad6bc84cca67bf10d7cd0dd
https://doi.org/10.1158/1538-7445.am2022-52

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Resolution ctDx FIRST plasma assay as a companion diagnostic for adagrasib and its application to longitudinal monitoring

Autor: Ira Pekker, Julia Pollak, Kristy Potts, PuiYee Chan, Chen-Hsun Tsai, Angela Liao, Carly Garrison, Taylor Brown, Paul Stull, Daniella Bianchi-Frias, Zhen Li, Christine Baker, Kavita Garg

Publikováno v: Journal of Clinical Oncology. 40:3057-3057

3057 Background: KRAS is one of the most commonly mutated oncogenes in cancer. There is a significant need for new treatment options for patients with non–small cell lung cancer (NSCLC) harboring the KRAS G12C mutation. Adagrasib is an investigatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f70785d98b7932028325c07d1056f7a2
https://doi.org/10.1200/jco.2022.40.16_suppl.3057

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Detection of HRD gene mutations and copy number changes in cfDNA from prostate cancer patients

Autor: Mark Li, Dan DiPasquo, Mehdi Dehghani, Lee Lim, Robert J. Amato, Jenny Hernandez, Yue Wang, Christopher K. Raymond, Reynolds Brobey, Kavita Garg, Kristy Potts

Publikováno v: Journal of Clinical Oncology. 35:e16546-e16546

e16546 Background: Recent genomic surveys of prostate cancer have identified somatic mutations in metastatic castration-resistant prostate cancer (mCRPC). In this study, we examined mCRPC patients for AR aberrations and mutations in the HRD (homologo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e48c3e75189c830968834c7411f8190c
https://doi.org/10.1200/jco.2017.35.15_suppl.e16546

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