Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Kristy Nichol"'
1
Akademický článek
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
Autor: Louisa L. Y. Chan, Danielle E. Anderson, Hong Sheng Cheng, Fransiskus Xaverius Ivan, Si Chen, Adrian E. Z. Kang, Randy Foo, Akshamal M. Gamage, Pei Yee Tiew, Mariko Siyue Koh, Ken Cheah Hooi Lee, Kristy Nichol, Prabuddha S. Pathinayake, Yik Lung Chan, Tsin Wen Yeo, Brian G. Oliver, Peter A. B. Wark, Linbo Liu, Nguan Soon Tan, Lin-Fa Wang, Sanjay H. Chotirmall
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived
Externí odkaz: https://doaj.org/article/ede2ba3eb3ee4bc2bdcf003223f85869
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2
Akademický článek
Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls
Autor: Banafshe Hosseini, Bronwyn S. Berthon, Malcolm R. Starkey, Adam Collison, Rebecca F. McLoughlin, Evan J. Williams, Kristy Nichol, Peter AB. Wark, Megan E. Jensen, Carla Rebeca Da Silva Sena, Katherine J. Baines, Joerg Mattes, Lisa G. Wood
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
BackgroundAsthma is the most frequent cause of hospitalisation among children; however, little is known regarding the effects of asthma on immune responses in children.ObjectiveThe present study aimed to evaluate cytokine responses of peripheral bloo
Externí odkaz: https://doaj.org/article/94cd4d28da3245f39a71250a10675ab2
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3
Akademický článek
The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses
Autor: Banafsheh Hosseini, Bronwyn S. Berthon, Megan E. Jensen, Rebecca F. McLoughlin, Peter A. B. Wark, Kristy Nichol, Evan J. Williams, Katherine J. Baines, Adam Collison, Malcolm R. Starkey, Joerg Mattes, Lisa G. Wood
Publikováno v: Nutrients, Vol 14, Iss 15, p 3087 (2022)
Children with asthma are at risk of acute exacerbations triggered mainly by viral infections. A diet high in fruit and vegetables (F&V), a rich source of carotenoids, may improve innate immune responses in children with asthma. Children with asthma (
Externí odkaz: https://doaj.org/article/48f97d8c24fc4e6cb43d9d999894aa8f
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5
Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing
Autor: Matt D. Johansen, Rashad M. Mahbub, Sobia Idrees, Duc H. Nguyen, Stefan Miemczyk, Prabuddha Pathinayake, Kristy Nichol, Nicole G. Hansbro, Linden J. Gearing, Paul J. Hertzog, David Gallego-Ortega, Warwick J. Britton, Bernadette M. Saunders, Peter A. Wark, Alen Faiz, Philip M. Hansbro
Publikováno v: American journal of respiratory and critical care medicine, 206(6):712-729
Rationale: Patients with chronic obstructive pulmonary disease (COPD) develop more severe coronavirus disease (COVID-19); however, it is unclear whether they are more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69985829978ce01300b0210155227ec
https://pubmed.ncbi.nlm.nih.gov/35612929
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7
Antiviral immunity is impaired in COPD patients with frequent exacerbations
Autor: Joseph Footitt, Peter A. B. Wark, Aran Singanayagam, Maria-Belen Trujillo Torralbo, Sebastian L. Johnston, Nathan W. Bartlett, Kristy Nichol, Su-Ling Loo, Andrew T. Reid, Punnam Chander Veerati, Patrick Mallia, Jason Girkin, Christopher Grainge, Maria Adelaide Calderazzo, Lydia J. Finney, Prabuddha S. Pathinayake, Eteri Bakhsoliani
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
L903
L893
Am J Physiol Lung Cell Mol Physiol
Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD) subgroup requiring better treatment options. The aim of this study was to determine the innate immune mechanisms that underlie susceptibility to frequent ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cbe7000ae9f11e1ac8cd0990e3310c
http://europepmc.org/articles/PMC6962603
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9
TLR7 agonist loaded airway epithelial targeting nanoparticles stimulate innate immunity and suppress viral replication in human bronchial epithelial cells
Autor: Stanislav Kan, Christopher Grainge, Kristy Nichol, Andrew Reid, Darryl Knight, Yong Sun, Nathan Bartlett, Mingtao Liang
Publikováno v: International Journal of Pharmaceutics. 617:121586
Nanoparticle-based delivery is a strategy for increasing the therapeutic window of inhaled immunomodulatory drugs that have inflammatory activity. TLR7 agonists are a class of immunomodulators that have been considered for the treatment of virus-indu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10632c49345523287d6f4c21b66c1fa9
https://doi.org/10.1016/j.ijpharm.2022.121586
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10
Human coronaviruses 229E and OC43 replicate and induce distinct antiviral responses in differentiated primary human bronchial epithelial cells
Autor: Alan C-Y. Hsu, Su-Ling Loo, Peter A. B. Wark, Camille Esneau, Nathan W. Bartlett, Kristy Nichol
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
The recurrent emergence of novel, pathogenic coronaviruses (CoVs) severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1; 2002), Middle East respiratory syndrome (MERS)-CoV (2012), and most recently SARS-CoV-2 (2019) has highlighted the need for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316f6212ecc8386eda6cf48a99a5f362
https://pubmed.ncbi.nlm.nih.gov/32903043
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