Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kristy M Heppner"'
Autor:
Kristy M Heppner, Diego ePerez-Tilve
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
Glucagon-like peptide-1 (GLP-1) enhances meal-related insulin secretion, which lowers blood glucose excursions. In addition to its incretin action, GLP-1 acts on the GLP-1 receptor (GLP-1R) in the brain to suppress feeding. These combined actions of
Externí odkaz:
https://doaj.org/article/f89f7166ecd6432f82536f9e8cbfe877
Autor:
Henriette Kirchner, Kristy M Heppner, Jenna Holland, Dhiraj Kabra, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61822 (2013)
Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin
Externí odkaz:
https://doaj.org/article/44b210890d6d43568d7899a3aa907c59
Autor:
Chun-Xia Yi, Kristy M Heppner, Henriette Kirchner, Jenny Tong, Maximillian Bielohuby, Bruce D Gaylinn, Timo D Müller, Erin Bartley, Harold W Davis, Yongmei Zhao, Anupama Joseph, Traci Kruthaupt, Nickki Ottaway, Dhiraj Kabra, Kirk M Habegger, Stephen C Benoit, Martin Bidlingmaier, Michael O Thorner, Diego Perez-Tilve, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32100 (2012)
OBJECTIVE:Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function mode
Externí odkaz:
https://doaj.org/article/bc467b72b5ea464ba3c01bca6c8e1ed1
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
Autor:
Yikai Shao, Ormond A. MacDougald, Katrina Granger, Darleen A. Sandoval, Kristy M. Heppner, Jae Hoon Shin, Ziru Li, Ruth Gutierrez-Aguilar, Samuel Chiang, Sara G. Vargo, Randy J. Seeley, Nadejda Bozadjieva-Kramer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19 which is in
Autor:
Katherine G. Tennant, Camdin M. Bennett, Kevin L. Grove, Kristy M. Heppner, Paul Kievit, Baylin J. Bennett, Charles T. Roberts, Wafa Hassouneh, Julie M. Carroll, Mads Tang-Christensen, Andrew J. Whittle, Mark W. Sleeman, Cadence True, Michael A. Cowley, Brandon L. Roberts, Anitra C. Wolf, Louise S. Dalbøge, Melissa A. Kirigiti, Sarah R. Lindsley, Colin Hall
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 26, Iss, Pp 18-29 (2019)
Molecular Metabolism, Vol 26, Iss, Pp 18-29 (2019)
Objective Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophreni
Publikováno v:
Diabetes
Bariatric surgery procedures, such as Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective interventions available for sustained weight loss and improved glucose metabolism. Bariatric surgery alters the entero
Autor:
Diana L. Takahashi, Kristy M. Heppner, Kirsten Raun, Ellen Marie Straarup, Gregory A. Dissen, Kevin L. Grove, Birgitte Andersen, Virginia Raffaele, Thora B. Bodvarsdottir, Katherine S. Lewandowski, Paul Kievit
Publikováno v:
International Journal of Obesity. 42:1151-1160
OBJECTIVE: Administration of FGF21 and FGF21 analogues reduce body weight; improve insulin sensitivity and dyslipidemia in animal models of obesity and in short term clinical trials. However potential adverse effects identified in mice have raised co
Autor:
Nickki Ottaway, Kristy M. Heppner, Jenna Holland, David L. Smiley, Sarah Marks, Richard D. DiMarchi, Diego Perez-Tilve
Publikováno v:
Diabetologia. 58:2124-2132
We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight los
Autor:
Melissa Kirigiti, Rikley Buckingham, Kevin L. Grove, Anna Secher, Lotte Bjerre Knudsen, Niels Vrang, Sarah Juel Paulsen, Kristy M. Heppner, Charles Pyke
Publikováno v:
Endocrinology. 156:255-267
Glucagon-like peptide-1 (GLP-1) is released from endocrine L-cells lining the gut in response to food ingestion. However, GLP-1 is also produced in the nucleus of the solitary tract, where it acts as an anorectic neurotransmitter and key regulator of
Autor:
Kristy M. Heppner, Jenny Tong
Publikováno v:
European Journal of Endocrinology. 171:R21-R32
Ghrelin is a 28-amino acid peptide secreted mainly from the X/A-like cells of the stomach. Ghrelin is found in circulation in both des-acyl (dAG) and acyl forms (AG). Acylation is catalyzed by the enzyme ghrelinO-acyltransferase (GOAT). AG acts on th