Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kristy M Heppner"'
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
Autor:
Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Yikai Shao, Ruth Gutierrez-Aguilar, Ziru Li, Kristy M. Heppner, Samuel Chiang, Sara G. Vargo, Katrina Granger, Darleen A. Sandoval, Ormond A. MacDougald, Randy J. Seeley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of m
Externí odkaz:
https://doaj.org/article/af44be2074044e2db785c4c8cb983aeb
Autor:
Brandon L. Roberts, Baylin J. Bennett, Camdin M. Bennett, Julie M. Carroll, Louise S. Dalbøge, Colin Hall, Wafa Hassouneh, Kristy M. Heppner, Melissa A. Kirigiti, Sarah R. Lindsley, Katherine G. Tennant, Cadence A. True, Andrew Whittle, Anitra C. Wolf, Charles T. Roberts, Jr., Mads Tang-Christensen, Mark W. Sleeman, Michael A. Cowley, Kevin L. Grove, Paul Kievit
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 18-29 (2019)
Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophren
Externí odkaz:
https://doaj.org/article/2fb89f157ba64298a2342ca376aaca21
Autor:
Kristy M Heppner, Diego ePerez-Tilve
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
Glucagon-like peptide-1 (GLP-1) enhances meal-related insulin secretion, which lowers blood glucose excursions. In addition to its incretin action, GLP-1 acts on the GLP-1 receptor (GLP-1R) in the brain to suppress feeding. These combined actions of
Externí odkaz:
https://doaj.org/article/f89f7166ecd6432f82536f9e8cbfe877
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
Autor:
Yikai Shao, Ormond A. MacDougald, Katrina Granger, Darleen A. Sandoval, Kristy M. Heppner, Jae Hoon Shin, Ziru Li, Ruth Gutierrez-Aguilar, Samuel Chiang, Sara G. Vargo, Randy J. Seeley, Nadejda Bozadjieva-Kramer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19 which is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a55322f3354056c624777e489425a6
https://doi.org/10.1038/s41467-021-24914-y
https://doi.org/10.1038/s41467-021-24914-y
Autor:
Katherine G. Tennant, Camdin M. Bennett, Kevin L. Grove, Kristy M. Heppner, Paul Kievit, Baylin J. Bennett, Charles T. Roberts, Wafa Hassouneh, Julie M. Carroll, Mads Tang-Christensen, Andrew J. Whittle, Mark W. Sleeman, Cadence True, Michael A. Cowley, Brandon L. Roberts, Anitra C. Wolf, Louise S. Dalbøge, Melissa A. Kirigiti, Sarah R. Lindsley, Colin Hall
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 26, Iss, Pp 18-29 (2019)
Molecular Metabolism, Vol 26, Iss, Pp 18-29 (2019)
Objective Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophreni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad358a49d1b18695f17a8716e6a105
https://doi.org/10.1016/j.molmet.2019.06.001
https://doi.org/10.1016/j.molmet.2019.06.001
Autor:
Henriette Kirchner, Kristy M Heppner, Jenna Holland, Dhiraj Kabra, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61822 (2013)
Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin
Externí odkaz:
https://doaj.org/article/44b210890d6d43568d7899a3aa907c59
Autor:
Chun-Xia Yi, Kristy M Heppner, Henriette Kirchner, Jenny Tong, Maximillian Bielohuby, Bruce D Gaylinn, Timo D Müller, Erin Bartley, Harold W Davis, Yongmei Zhao, Anupama Joseph, Traci Kruthaupt, Nickki Ottaway, Dhiraj Kabra, Kirk M Habegger, Stephen C Benoit, Martin Bidlingmaier, Michael O Thorner, Diego Perez-Tilve, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32100 (2012)
OBJECTIVE:Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function mode
Externí odkaz:
https://doaj.org/article/bc467b72b5ea464ba3c01bca6c8e1ed1
Publikováno v:
Diabetes
Bariatric surgery procedures, such as Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective interventions available for sustained weight loss and improved glucose metabolism. Bariatric surgery alters the entero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68c110d057b1aea03f2ee605240b9d0
https://doi.org/10.2337/dbi17-0007
https://doi.org/10.2337/dbi17-0007
Autor:
Diana L. Takahashi, Kristy M. Heppner, Kirsten Raun, Ellen Marie Straarup, Gregory A. Dissen, Kevin L. Grove, Birgitte Andersen, Virginia Raffaele, Thora B. Bodvarsdottir, Katherine S. Lewandowski, Paul Kievit
Publikováno v:
International Journal of Obesity. 42:1151-1160
OBJECTIVE: Administration of FGF21 and FGF21 analogues reduce body weight; improve insulin sensitivity and dyslipidemia in animal models of obesity and in short term clinical trials. However potential adverse effects identified in mice have raised co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff565cb04ebf2f780d0026f9b6c1a8b
https://doi.org/10.1038/s41366-018-0080-7
https://doi.org/10.1038/s41366-018-0080-7
Autor:
Nickki Ottaway, Kristy M. Heppner, Jenna Holland, David L. Smiley, Sarah Marks, Richard D. DiMarchi, Diego Perez-Tilve
Publikováno v:
Diabetologia. 58:2124-2132
We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d61431dcf71a937fe708fa63da3c24d
https://doi.org/10.1007/s00125-015-3651-3
https://doi.org/10.1007/s00125-015-3651-3