Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kristy Kuplast"'
Autor:
Chang Liu, Manish Patel, Gerald Falchook, Patricia LoRusso, Timothy Yap, Melissa Johnson, Kristy Kuplast-Barr, Ryan Abo, Erika Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/c69f81a7d6be48219521485df3d41f01
Autor:
Heike Keilhack, Kevin Kuntz, Sudha Parasuraman, Lisa A Beck, Christopher T Richardson, Viviana Bozon, Kristen McEachern, Kerren Swinger, Laurie B Schenkel, Jennifer R Molina, Nicholas Perl, Danielle Blackwell, Jonathan Novak, Harsimran Kaur, Kristy Kuplast-Barr, Colin Coutts, Elizabeth Mateer, Bin Gui, Kaiko Kunii, Melissa Vasbinder, Mario Niepel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e2a2ade259e4fdf6f3b23aaf753881
https://doi.org/10.26226/m.64199a03c37f0d0019bb7680
https://doi.org/10.26226/m.64199a03c37f0d0019bb7680
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f0193e841ebe292cdd7fd3a4087a01
https://doi.org/10.1158/1535-7163.c.6537771.v1
https://doi.org/10.1158/1535-7163.c.6537771.v1
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
PDF File -1 MB, Supplemental data is to further support the statements made it the main text. Captions: Supplemental Table 1: Cell Lines used in the CRISPR pooled screen. Supplemental Table 2: Table of ovarian lines screened for tazemetostat sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28078359a52e1425c550d2baf2f9465b
https://doi.org/10.1158/1535-7163.22504545
https://doi.org/10.1158/1535-7163.22504545
Autor:
Timothy A. Yap, Andres Cervantes, Gerald S. Falchook, Manish R. Patel, Dejan Juric, Saiama N. Waqar, Erin L. Schenk, Geoffrey Shapiro, Valentina Boni, Cesar A. Perez, Barbara Burtness, Yana G. Najjar, Fabricio Racca, Katerin Rojas, Kristy Kuplast-Barr, Kristen McEachern, Manoj Samant, Viviana Bozón, Sudha Parasuraman, Melissa Johnson
Publikováno v:
Cancer Research. 83:CT109-CT109
Background: PARP7 is a stress-induced monoART that suppresses the cellular type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PARP7 inhibitor that induces IFN and an adaptive immune response. The t
Publikováno v:
Cancer Research. 83:2508-2508
Introduction: PARP7, encoded by the TIPARP gene, is a monoART involved in cellular stress responses and with immunomodulatory functions in cancer. The PARP7 gene is amplified in a subset of squamous cell carcinomas and ongoing clinical studies are as
Autor:
Kristy Kuplast-Barr, Melissa Johnson, Manish Patel, Timothy Yap, Gerald Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundPARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PARP
Autor:
Kristy Kuplast-Barr, Melissa L. Johnson, Manish R. Patel, Timothy A. Yap, Gerald S. Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika L. Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern
Publikováno v:
Cancer Research. 82:1836-1836
Background: PARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PA
Autor:
Tim J. Wigle, Luke Utley, Kevin Wayne Kuntz, Jeff Song, Jan-Rung Mo, W. David Church, Sunaina P. Nayak, Heike Keilhack, Yue Ren, Alvin Lu, Danielle J. Blackwell, Ryan Abo, Kaiko Kunii, Christina R. Majer, Ahmed S.A. Mady, Melissa M. Vasbinder, Ellen Bamberg, Kerren Kalai Swinger, Bin Gui, Victoria M. Richon, Mario Niepel, Patricia E. Rao, Kristy Kuplast-Barr, Jennifer R. Molina, Timothy J. Mitchison, Joseph M. Gozgit, Elena Minissale, Zacharenia A. Varsamis
Publikováno v:
Cancer cell. 39(9)
PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition of PARP7 restores type I interf
Autor:
Tim J. Wigle, Elena Minissale, Alvin Lu, Kristy Kuplast-Barr, W. David Church, Jennifer R. Molina, Heike Keilhack, Kaiko Kunii, Anne Cheung, Yue Ren, Christina R. Majer, Christopher Reik, Kevin Wayne Kuntz, Mario Niepel, Victoria M. Richon, Laurie B. Schenkel, Kerren Kalai Swinger, Jan-Rung Mo, Danielle J. Blackwell, Ryan Abo, Melissa M. Vasbinder
Publikováno v:
Cell Chemical Biology. 28:1158-1168.e13
Summary PARP14 has been implicated by genetic knockout studies to promote protumor macrophage polarization and suppress the antitumor inflammatory response due to its role in modulating interleukin-4 (IL-4) and interferon-γ signaling pathways. Here,