Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristy Koselny"'
Autor:
Kristy Koselny, Nebibe Mutlu, Annabel Y. Minard, Anuj Kumar, Damian J. Krysan, Melanie Wellington
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis
Externí odkaz:
https://doaj.org/article/5a846ae95af84dc7bb22353437472831
Autor:
Teresa R. O’Meara, Kwamaa Duah, Cynthia X. Guo, Michelle E. Maxson, Ryan G. Gaudet, Kristy Koselny, Melanie Wellington, Michael E. Powers, Jessie MacAlpine, Matthew J. O’Meara, Amanda O. Veri, Sergio Grinstein, Suzanne M. Noble, Damian Krysan, Scott D. Gray-Owen, Leah E. Cowen
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans un
Externí odkaz:
https://doaj.org/article/37c1c8c11e4b4ed3843ff6f59b92ef9d
Autor:
Virginia E Glazier, Thomas Murante, Daniel Murante, Kristy Koselny, Yuan Liu, Dongyeop Kim, Hyun Koo, Damian J Krysan
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006948 (2017)
Biofilm formation by Candida albicans is a key aspect of its pathobiology and is regulated by an integrated network of transcription factors (Bcr1, Brg1, Efg1, Ndt80, Rob1, and Tec1). To understand the details of how the transcription factors functio
Externí odkaz:
https://doaj.org/article/66d193f02cf34db08cd18c28a347d39a
Autor:
Arielle Butts, Kristy Koselny, Yeissa Chabrier-Roselló, Camile P. Semighini, Jessica C. S. Brown, Xuying Wang, Sivakumar Annadurai, Louis DiDone, Julie Tabroff, Wayne E. Childers, Magid Abou-Gharbia, Melanie Wellington, Maria E. Cardenas, Hiten D. Madhani, Joseph Heitman, Damian J. Krysan
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we charac
Externí odkaz:
https://doaj.org/article/a47f62ddda0341948a47a260086195b2
Publikováno v:
mBio, Vol 4, Iss 1 (2013)
ABSTRACT The interaction of Candida albicans with macrophages induces the production of interleukin 1β (IL-1β) through inflammasome activation in a process that is required for host survival. C. albicans hypha formation has been linked to IL-1β pr
Externí odkaz:
https://doaj.org/article/edfd31080ece4f62b665304589a00c42
Autor:
Melanie T. Cushion, Justin P. Halterman, Kristy Koselny, Thomas F. Patterson, Nathan P. Wiederhold, Annette W. Fothergill, Damian J. Krysan, Chad Rappelye, Louis DiDone, Melanie Wellington, Julianne Green
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7115-7127
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848aaea83d880fed040e90734333b35f
https://doi.org/10.1128/aac.01061-16
https://doi.org/10.1128/aac.01061-16
Autor:
Anuj Kumar, Nebibe Mutlu, Kristy Koselny, Melanie Wellington, Damian J. Krysan, Annabel Y. Minard
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
mBio, Vol 9, Iss 4, p e01204-18 (2018)
mBio, Vol 9, Iss 4, p e01204-18 (2018)
Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans . In vitro , C. albicans triggers macrophage NLRP3- Casp1/11 -mediated pyroptosis, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20028fa02c100471d6ab241a7ec9884
https://doi.org/10.1128/mbio.01204-18
https://doi.org/10.1128/mbio.01204-18
Autor:
Leah E. Cowen, Amanda O. Veri, Michelle E. Maxson, Scott D. Gray-Owen, Michael E. Powers, Melanie Wellington, Kwamaa Duah, Kristy Koselny, Suzanne M. Noble, Sergio Grinstein, Cynthia X. Guo, Damian J. Krysan, Ryan G. Gaudet, Matthew J. O’Meara, Teresa R. O’Meara, Jessie MacAlpine
Publikováno v:
Microbial Cell
mBio, vol 9, iss 4
mBio
mBio, Vol 9, Iss 4, p e01581-18 (2018)
mBio, Vol 9, Iss 4 (2018)
mBio, vol 9, iss 4
mBio
mBio, Vol 9, Iss 4, p e01581-18 (2018)
mBio, Vol 9, Iss 4 (2018)
The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans undergoes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be55fe2faa77183175ac93343ff51d9
https://pubmed.ncbi.nlm.nih.gov/30533421
https://pubmed.ncbi.nlm.nih.gov/30533421
Autor:
Virginia E, Glazier, Thomas, Murante, Kristy, Koselny, Daniel, Murante, Marisol, Esqueda, Gina A, Wall, Melanie, Wellington, Chiung-Yu, Hung, Anuj, Kumar, Damian J, Krysan
Publikováno v:
G3: Genes|Genomes|Genetics
Genetic interaction analysis is a powerful approach to the study of complex biological processes that are dependent on multiple genes. Because of the largely diploid nature of the human fungal pathogen Candida albicans, genetic interaction analysis h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93d48861f7213f45c909ae136a98b205
https://pubmed.ncbi.nlm.nih.gov/29472308
https://pubmed.ncbi.nlm.nih.gov/29472308
Autor:
José A. Lemos, Jacqueline Abranches, Anthony O. Gaca, Jorge E. Mendoza, Marcia Giambiagi-deMarval, Jessica K. Kajfasz, Melanie Wellington, Kristy Koselny, James H. Miller
Publikováno v:
Infection and Immunity. 80:2265-2275
The ability to cope with endogenous or host-generated reactive oxygen species is considered a key virulence attribute of the opportunistic pathogen Enterococcus faecalis , a leading cause of hospital-acquired infections. In this study, we used in sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632264af4c7a6c6f10f5df1a81202c2b
https://doi.org/10.1128/iai.00026-12
https://doi.org/10.1128/iai.00026-12