Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristy Haas"'
Autor:
Giordano Caponigro, Emmanuelle di Tomaso, William R. Sellers, Iain Mulford, Sunkyu Kim, Alice Loo, Scott Delach, Michael G. Acker, Maria Pinzon-Ortiz, Barbara Schacher Engstler, Ralph Tiedt, Christopher Thomas Brain, Thomas Horn, Rajiv Chopra, Kristy Haas, Steven Kovats, Alexander Cao
Publikováno v:
Oncotarget
Inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) is associated with robust antitumor activity. Ribociclib (LEE011) is an orally bioavailable CDK4/6 inhibitor that is approved for the treatment of hormone receptor-positive, human epidermal grow
Autor:
Sunkyu Kim, Ralph Tiedt, Alice Loo, Thomas Horn, Scott Delach, Steven Kovats, Kristy Haas, Barbara Schacher Engstler, Alexander Cao, Maria Pinzon-Ortiz, Iain Mulford, Michael G. Acker, Rajiv Chopra, Christopher Brain, Emmanuelle di Tomaso, William R. Sellers, Giordano Caponigro
Publikováno v:
Oncotarget
Autor:
Craig Mickanin, Linda Bagdasarian, Gregory R. Hoffman, Jeffery A. Porter, Kay Xiang, Huili Zhai, Zainab Jagani, Matthew J. Meyer, Frank Buxton, Vic E. Myer, Nadire Ramadan, Rami Rahal, Elizabeth Frias, Charles W. M. Roberts, Janina Huber, Frank Stegmeier, Kristy Haas, Gregory McAllister, Tanushree Phadke, Mariela Jaskelioff, Rodrigo Romero, Veronica Saenz-Vash, Alicia Lindeman, Dongshu Chen, Boris G. Wilson, Margaret E. McLaughlin, Nicholas Keen
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3128-3133
Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic candidates. We therefore set out to systematically interrogate epigenetic cancer dependenc
Autor:
Christine Stephan, William R. Sellers, Deborah Castelletti, Jeffery A. Porter, Julie L. Bernard, Sandra Mollé, Mark Stump, Tami Hood, Joshua M. Korn, Audrey Kauffmann, Giorgio G. Galli, Kristine Yu, Li Li, Marc Hattenberger, Javad Golji, Zainab Jagani, Marco Wallroth, Tobias Schmelzle, Philippe Megel, Raymond Pagliarini, Rosemary Barrett, Yingzi Yue, Richard S. Eldridge, Jan Weiler, Alberto C. Vitari, Konstantinos J. Mavrakis, Kalyani Gampa, Elizabeth Ackley, Rosalie deBeaumont, Qiong Shen, Joel Berger, Tanja Schouwey, Franklin Chung, E. Robert McDonald, Gregory McAllister, Christelle Stamm, Frances Shanahan, Aurore Desplat, Iris Kao, Thomas A. Perkins, Antoine de Weck, Kavitha Venkatesan, Albert Lai, Jennifer Johnson, Roland Widmer, David A. Ruddy, Avnish Kapoor, Brian Repko, François Gauter, Nicholas Keen, Tanushree Phadke, Eric Billy, Sosathya Sovath, Typhaine Martin, Elizabeth Frias, Justina X. Caushi, Vic E. Myer, Malini Varadarajan, William C. Forrester, Fei Feng, Hans Bitter, Ralph Tiedt, Yue Liu, Jing Zhang, Dorothee Abramowski, Dhiren Belur, Volker M. Stucke, Odile Weber, Mathias Jenal, Ali Farsidjani, Jianjun Yu, Rebecca Billig, JiaJia Feng, A. B. Meyer, Kristen Hurov, Veronica Gibaja, Michael D. Jones, Daisy Flemming, Donald A. Dwoske, Jilin Liu, Clara Delaunay, William Duong, Frank Buxton, Kaitlin J. Macchi, Saskia M. Brachmann, Alice T. Loo, Craig Mickanin, Francesco Hofmann, Frank Stegmeier, Kristy Haas, Gregory R. Hoffman, Marta Cortes-Cros, Roger Caothien, Shumei Liu, Serena J. Silver, Michael R. Schlabach, Emma Lees, Nadire Ramadan, Qiumei Liu, Zhenhai Gao
Publikováno v:
Cell. 170:577-592.e10
Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the disco
Autor:
Margaret E. McLaughlin, Tanushree Phadke, Charles W. M. Roberts, Boris G. Wilson, Kay Xiang, Linda Bagdasarian, Rami Rahal, Janina Huber, Zainab Jagani, Nicholas Keen, Craig Mickanin, Matthew J. Meyer, Rodrigo Romero, Frank Stegmeier, Nadire Ramadan, Gregory R. Hoffman, Gregory McAllister, Elizabeth Frias, Mariela Jaskelioff, Vic E. Myer, Jeffrey A. Porter, Dongshu Chen, Frank Buxton, Alicia Lindeman, Kristy Haas
Publikováno v:
Molecular Cancer Therapeutics. 12:PR06-PR06
Epigenetic dysregulation is an emerging hallmark of cancers, and the identification of recurrent somatic mutations in chromatin regulators implies a causal role for altered chromatin states in tumorigenesis. As the majority of epigenetic mutations ar