Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kristy Chung"'
Autor:
Wrona Wojciech, Deborah J. Davis, Hayley Angove, Christopher Thomas Brain, Alison Jo-Anne Woolford, Fan Yang, Kim Lewry, Hong Cheng, Steven Kovats, Chen Christine Hiu-Tung, Alice Loo, Mei Xu, Claudio Dagostin, Miles Congreve, David C. Rees, John William Giraldes, Yaping Wang, Young Shin Cho, Glyn Williams, Rachel McMenamin, Troy Smith, Junqing Shen, Rajiv Chopra, Ruth Feltell, Yipin Lu, Wiesia Maniara, Bharat Lagu, Steven Howard, Kristy Chung, Robert Cheng, Steven Douglas Hiscock, Sunkyu Kim, Luzzio Michael, Marc O'Reilly, Rajdeep Benning, Paul N. Mortenson
Publikováno v:
ACS Medicinal Chemistry Letters. 3:445-449
Herein, we describe the discovery of potent and highly selective inhibitors of both CDK4 and CDK6 via structure-guided optimization of a fragment-based screening hit. CDK6 X-ray crystallography and pharmacokinetic data steered efforts in identifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f4930f1dba54c810db018516d6ce6
https://doi.org/10.1021/ml200241a
https://doi.org/10.1021/ml200241a
Autor:
Christopher Thomas Brain, Kristy Chung, Markus Vögtle, Ming Xu, Yipin Lu, Hong Cheng, James M. Groarke, Marc O'Reilly, Ying Hou, Chen Christine Hiu-Tung, Mei Xu, Steven Kovats, Moo Je Sung, Troy Smith, Sunkyu Kim, G M Trakshel, Young Shin Cho, He Guo, Junqing Shen, Maria Borland, Rajiv Chopra
Publikováno v:
Journal of Medicinal Chemistry. 53:7938-7957
Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ca1084815aeaf5b1449a83ece0ad7a
https://doi.org/10.1021/jm100571n
https://doi.org/10.1021/jm100571n
Publikováno v:
Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses. 20(5)
Using steps in the Iowa Model of Evidence-Based Practice, nursing staff developed and piloted a standardized shift report tool on one medical-surgical unit in a large tertiary care hospital. Pilot outcomes showed shift reports with decreased frequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6035e406407d26fb8034413533de7d3
https://pubmed.ncbi.nlm.nih.gov/22165785
https://pubmed.ncbi.nlm.nih.gov/22165785
Autor:
Michihiro Araki, Kristy Chung, Mads Kærn, Timothy S. Gardner, Hideki Kobayashi, James J. Collins, Charles R. Cantor
Novel cellular behaviors and characteristics can be obtained by coupling engineered gene networks to the cell's natural regulatory circuitry through appropriately designed input and output interfaces. Here, we demonstrate how an engineered genetic ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa78a7e8970543cc7911b8ffd87feec6
https://europepmc.org/articles/PMC420408/
https://europepmc.org/articles/PMC420408/
Autor:
Lee, Kathy Y. S.1 (AUTHOR) Kathy-lee@cuhk.edu.hk, Crooke, Pamela J.2 (AUTHOR), Lui, Aster L. Y.1 (AUTHOR), Kan, Peggy P. K.1 (AUTHOR), Mark, Yuen-mai3 (AUTHOR), van Hasselt, Charles Andrew1 (AUTHOR), Tong, Michael C. F.1 (AUTHOR)
Publikováno v:
International Journal of Disability, Development & Education. Mar2016, Vol. 63 Issue 2, p201-223. 23p.
Autor:
Ng, Louisa K. Y., Lee, Kathy Y. S., Chiu, Sung Nok, Ku, Peter K. M., van Hasselt, C. Andrew, Tong, Michael C. F.
Publikováno v:
Head & Neck; Sep2011, Vol. 33 Issue 9, p1335-1339, 5p, 5 Charts, 1 Graph
Publikováno v:
MEDSURG Nursing; Sep/Oct2011, Vol. 20 Issue 5, p255-268, 7p, 2 Charts
Autor:
Chen, Bor-Sen
In this book, the synthetic gene circuits are modeled by nonlinear stochastic systems to consider random genetic variations and random in vivo environmental disturbances. The authors'design purpose is to engineer a robust genetic circuit to achieve a