Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kristy Boggs"'
Autor:
Kristy Boggs, Ting Wang, Abrahim I. Orabi, Amitava Mukherjee, John F. Eisses, Tao Sun, Li Wen, Tanveer A. Javed, Farzad Esni, Wei Chen, Sohail Z. Husain
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract It is well known that pancreatic recovery after a single episode of injury such as an isolated bout of pancreatitis occurs rapidly. It is unclear, however, what changes are inflicted in such conditions to the molecular landscape of the pancr
Externí odkaz:
https://doaj.org/article/69e80f3f1fcb461aaae46aed4750a6cc
Autor:
Abrahim I. Orabi, Li Wen, Tanveer A. Javed, Tianming Le, Ping Guo, Subramaniam Sanker, David Ricks, Kristy Boggs, John F. Eisses, Carlos Castro, Xiangwei Xiao, Krishna Prasadan, Farzad Esni, George K. Gittes, Sohail Z. Husain
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 119-128 (2017)
Background & Aims: There is a pressing need to develop effective preventative therapies for postâendoscopic retrograde cholangiopancreatography pancreatitis (PEP). We showed that early PEP events are induced through the calcium-activated phosphatase
Externí odkaz:
https://doaj.org/article/769b11edcc3e473db6865e44af6f256c
Autor:
Xiang Chen, Armita Bahrami, Alberto Pappo, John Easton, James Dalton, Erin Hedlund, David Ellison, Sheila Shurtleff, Gang Wu, Lei Wei, Matthew Parker, Michael Rusch, Panduka Nagahawatte, Jianrong Wu, Shenghua Mao, Kristy Boggs, Heather Mulder, Donald Yergeau, Charles Lu, Li Ding, Michael Edmonson, Chunxu Qu, Jianmin Wang, Yongjin Li, Fariba Navid, Najat C. Daw, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Jinghui Zhang, Michael A. Dyer
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 104-112 (2014)
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To define the landscape of somatic mutations in pediatric osteosarcoma, we performed whole-geno
Externí odkaz:
https://doaj.org/article/40f55a27461a4869b9e264b8b60dc172
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demo
Externí odkaz:
https://doaj.org/article/0e5d590edc224652bfd2a253b02bf639
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Chloride (Cl(−)) channels in the apical membrane of biliary epithelial cells (BECs), also known as cholangiocytes, provide the driving force for biliary secretion. Although two Cl(−) channels have been identified on a molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a7bf77d29ce25dd89331d1ca38b6e2
https://pubmed.ncbi.nlm.nih.gov/35445421
https://pubmed.ncbi.nlm.nih.gov/35445421
Autor:
Al Karim Khimji, Youxue Wang, Amal K. Dutta, Charles Kresge, Andrew Feranchak, Kristy Boggs, Yonas Getachew, Don C. Rockey
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
TMEM16A is a Ca2+-activated Cl−channel in the apical membrane of biliary epithelial cells, known as cholangiocytes, which contributes importantly to ductular bile formation. Whereas cholangiocyte TMEM16A activity is regulated by extracellular ATP-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5e781437b14f9c5a4f052cddbef53b
https://doi.org/10.1152/ajpgi.00219.2019
https://doi.org/10.1152/ajpgi.00219.2019
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Mechanosensitive signaling has emerged as a mechanism for the regulation of cholangiocyte transport and bile formation. The mechanical effect of fluid-flow, or shear, at the apical membrane of cholangiocytes regulates secretion through a process invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710ca1ffa042326dcd43aca51d35599f
https://doi.org/10.1152/ajpgi.00176.2019
https://doi.org/10.1152/ajpgi.00176.2019
Autor:
Brent L. Russell, Celeste Rosencrance, Xiaoyan Zhu, Rachel M. Noyes, Yiping Fan, Donald Yergeau, David Finkelstein, Hongjian Jin, Suzanne J. Baker, Ying Shao, Junyuan Zhang, Jinghui Zhang, Andre B. Silveira, Michael Rusch, Timothy I. Shaw, David W. Ellison, Stanley Pounds, Cynthia Wetmore, Gang Wu, Jon D. Larson, Alberto Broniscer, Liang Ding, Beisi Xu, Lawryn H. Kasper, Kristy Boggs, John Easton
Publikováno v:
Acta Neuropathologica. 137:637-655
Histone H3 K27M mutation is the defining molecular feature of the devastating pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). The prevalence of histone H3 K27M mutations indicates a critical role in DIPGs, but the contribution of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9336427f65ba87c4aecd1da824d81f7e
https://doi.org/10.1007/s00401-019-01975-4
https://doi.org/10.1007/s00401-019-01975-4
Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping
Autor:
Liying Fan, Timothy I. Shaw, Kristy Boggs, Philip M. Potter, Michael Rusch, Jinghui Zhang, Thomas R. Webb, Michael N. Edmonson, John Easton, Gang Wu
Publikováno v:
RNA. 24:1056-1066
The recent identification of compounds that interact with the spliceosome (sudemycins, spliceostatin A, and meayamycin) indicates that these molecules modulate aberrant splicing via SF3B1 inhibition. Through whole transcriptome sequencing, we have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0674193f58f79ededfb7e4362a4693
https://doi.org/10.1261/rna.065383.117
https://doi.org/10.1261/rna.065383.117
Autor:
Farzad Esni, Tanveer A. Javed, Subramaniam Sanker, Tianming Le, Krishna Prasadan, Ping Guo, George K. Gittes, Abrahim I. Orabi, Carlos A. Castro, Li Wen, Sohail Z. Husain, Xiangwei Xiao, David Ricks, Kristy Boggs, John F. Eisses
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 119-128 (2017)
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 119-128 (2017)
Background & Aims: There is a pressing need to develop effective preventative therapies for postâendoscopic retrograde cholangiopancreatography pancreatitis (PEP). We showed that early PEP events are induced through the calcium-activated phosphatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a7719cf055f2ccb796a3f0c2fd7893
https://doi.org/10.1016/j.jcmgh.2016.08.006
https://doi.org/10.1016/j.jcmgh.2016.08.006