Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristopher W. Brannan"'
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108350- (2020)
Summary: Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA mo
Externí odkaz:
https://doaj.org/article/a4f35ebdfeda4d2e94032f5c03770e2e
Autor:
Shengyu Li, Pengzhi Zhang, Weiqing Chen, Lingqun Ye, Kristopher W. Brannan, Nhat-Tu Le, Jun-ichi Abe, John P. Cooke, Guangyu Wang
Publikováno v:
Nature Biotechnology.
RNA velocity provides an approach for inferring cellular state transitions from single-cell RNA sequencing (scRNA-seq) data. Conventional RNA velocity models infer universal kinetics from all cells in an scRNA-seq experiment, resulting in unpredictab
Autor:
Wenhao Jin, Kristopher W. Brannan, Katannya Kapeli, Samuel S. Park, Hui Qing Tan, Maya L. Gosztyla, Mayuresh Mujumdar, Joshua Ahdout, Bryce Henroid, Katherine Rothamel, Joy S. Xiang, Limsoon Wong, Gene W. Yeo
RNA-binding proteins (RBPs) control RNA metabolism to orchestrate gene expression, and dysfunctional RBPs underlie many human diseases. Proteome-wide discovery efforts predict thousands of novel RBPs, many of which lack canonical RNA-binding domains.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b2f7034d5b7edfb9d6435834b8417d
https://doi.org/10.2139/ssrn.4319529
https://doi.org/10.2139/ssrn.4319529
Autor:
Pratibha Jagannatha, Kevin D. Dong, Eric Kofman, Ryan J. Marina, Assael A. Madrigal, Jason G. Underwood, Isaac A. Chaim, Brian A. Yee, Gene W. Yeo, Daniel A. Lorenz, Kristopher W. Brannan
Publikováno v:
Nature methods
RNA-binding proteins (RBPs) are critical regulators of gene expression and RNA processing that are required for gene function. Yet the dynamics of RBP regulation in single cells is unknown. To address this gap in understanding, we developed STAMP (Su
Autor:
Joy S. Xiang, Jasmine R. Mueller, En-Ching Luo, Brian A. Yee, Danielle Schafer, Jonathan C. Schmok, Frederick E. Tan, Katherine Rothamel, Rachael N. McVicar, Elizabeth M. Kwong, Krysten L. Jones, Hsuan-Lin Her, Chun-Yuan Chen, Anthony Q. Vu, Wenhao Jin, Samuel S. Park, Phuong Le, Kristopher W. Brannan, Eric R. Kofman, Yanhua Li, Alexandra T. Tankka, Kevin D. Dong, Yan Song, Aaron F. Carlin, Eric L. Van Nostrand, Sandra L. Leibel, Gene W. Yeo
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipita
Autor:
En-Ching Luo, Anthony Q. Vu, Eric Kofman, Sandra L Leibel, Aaron F. Carlin, Eric L. Van Nostrand, Jonathan C. Schmok, Elizabeth M. Kwong, Danielle Schafer, Brian A. Yee, Gene W. Yeo, Jasmine R. Mueller, Frederick E. Tan, Joy Shengnan Xiang, Yan Song, Kristopher W. Brannan, Alexandra T. Tankka, Yanhua Li, Phuong Le, Kevin D. Dong, Hsuan-Lin Her, Samuel S. Park, Krysten Leigh Jones, Rachael N. McVicar, Chun-Yuan Chen, Wenhao Jin
Publikováno v:
SSRN Electronic Journal.
The COVID-19 pandemic was caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs. SARS-CoV-2 proteins,
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108350-(2020)
Cell Rep
Cell Rep
Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits. Nuclease-dead RNA-targeting CRISPR-Cas systems recruit functional effectors to RNA molecules i
Autor:
Michael A. Cortazar, Ryan M. Sheridan, Kira Glover-Cutter, Nova Fong, Benjamin Erickson, David Bentley, Kristopher W. Brannan
Publikováno v:
Mol Cell
Control of transcription speed, which influences many co-transcriptional processes, is poorly understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA polymerase II (Pol II) elongation rate. The PNUTS W401A mutation, which disr
Autor:
Shai Karp, Tram Nguyen, Michael A. Cortazar, Ryan M. Sheridan, Nova Fong, Hyunmin Kim, Kristopher W. Brannan, Benjamin Erickson, David Bentley
Publikováno v:
Molecular Cell. 60:256-267
The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the 5'PO4-end exposed by nascent RNA cleavage and chases down the RNA polymerase. We tested this mechanism using a dominant-negative human Xrn2 mutant and found
Autor:
Gene W. Yeo, Kristopher W. Brannan
Publikováno v:
Molecular cell. 64(3)
Interactions between noncoding RNAs and chromatin proteins play important roles in gene regulation, but the molecular details of most of these interactions are unknown. Using protein-RNA photo-crosslinking and mass spectrometry on embryonic stem cell