Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kristopher M. Kahlig"'
Autor:
Kristopher M, Kahlig, Liam, Scott, Robert J, Hatch, Andrew, Griffin, Gabriel, Martinez Botella, Zoë A, Hughes, Marion, Wittmann
Publikováno v:
Epilepsia. 63:697-708
This study investigates the effects of PRAX-562 on sodium current (IInhibition of IPRAX-562 potently and preferentially inhibited persistent IPRAX-562 demonstrated robust preclinical anticonvulsant activity similar to CBZ but improved compared to LTG
Autor:
Brian Edward Marron, Brett Antonio, Griffin Andrew, Robert John Hatch, Zoë A Hughes, Kristopher M Kahlig, Mark L. Chapman, Gabriel Martinez-Botella, Marion Wittmann
Publikováno v:
ACS Medicinal Chemistry Letters. 12:593-602
The gene KCNT1 encodes the sodium-activated potassium channel KNa1.1 (Slack, Slo2.2). Variants in the KCNT1 gene induce a gain-of-function (GoF) phenotype in ionic currents and cause a spectrum of intractable neurological disorders in infants and chi
Autor:
Dao W Wang, Akshitkumar M Mistry, Kristopher M Kahlig, Jennifer A Kearney, Jizhou eXiang, Alfred L George
Publikováno v:
Frontiers in Pharmacology, Vol 1 (2010)
Propranolol is a widely-used, nonselective ß-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for ß-adrenergic re
Externí odkaz:
https://doaj.org/article/cf41fa6279d1418eb2b8e3111e369fbf
Publikováno v:
Biological Psychiatry. 89:S204
Autor:
Thomas O'Hara, James R. Priest, Jason B. Harris, Marco V Perez, Luiz Belardinelli, Kristopher M. Kahlig, Thomas Quertermous, John A. West, Scott R. Ceresnak, Joseph K. Yu, Patrick M. Boyle, Daniela Macaya, Sean Michael Boyle, Euan A. Ashley, Megan E. Grove, Michael J. Clark, Charles Gawad, Sarah Garcia, Sridharan Rajamani, Stephen R. Quake, Natalia A. Trayanova, Katsuhide Maeda, Richard Chen, Lindsey Malloy-Walton, Christian Antolik, Kyla Dunn, Norma F. Neff, Anne M. Dubin, Frederick E. Dewey
Publikováno v:
Proceedings of the National Academy of Sciences. 113:11555-11560
Somatic mosaicism, the occurrence and propagation of genetic variation in cell lineages after fertilization, is increasingly recognized to play a causal role in a variety of human diseases. We investigated the case of life-threatening arrhythmia in a
Autor:
Donglin Guo, Nevena Mollova, Elfatih Elzein, Sridharan Rajamani, Nesrine El-Bizri, Gongxin Liu, Luiz Belardinelli, Kristopher M. Kahlig, Jeff Zablocki, Xiao-Liang Chen, Cindy Hong Li
Publikováno v:
British Journal of Pharmacology. 173:3088-3098
Background and Purpose Enhanced late Na+ current (late INa) in the myocardium is pro-arrhythmic. Inhibition of this current is a promising strategy to stabilize ventricular repolarization and suppress arrhythmias. Here, we describe GS-6615, a selecti
Autor:
Sridharan Rajamani, Fernanda Justo, Richard L. Verrier, Kristopher M. Kahlig, Bruce D. Nearing, Luiz Belardinelli, Henrique Fuller
Publikováno v:
Heart Rhythm. 13:1679-1686
The cardiac late sodium current (INa) has been increasingly implicated in the initiation of atrial fibrillation (AF). Eleclazine (formerly known as GS-6615) is a new selective late INa inhibitor and is undergoing clinical testing for the treatment of
Autor:
Kristopher M. Kahlig, Michael Krause, Ming Yang, Arvinder K. Dhalla, Sridharan Rajamani, Yun Ning, Luiz Belardinelli
Publikováno v:
Diabetes. 63:3545-3556
Pancreatic α-cells express voltage-gated Na+ channels (NaChs), which support the generation of electrical activity leading to an increase in intracellular calcium, and cause exocytosis of glucagon. Ranolazine, a NaCh blocker, is approved for treatme
Autor:
Sridharan Rajamani, Kristopher M. Kahlig, Lynda Liu, Ryoko Hirakawa, Alfred L. George, Luiz Belardinelli
Publikováno v:
Molecular Pharmacology. 85:162-174
Ranolazine is an approved drug for chronic stable angina that acts by suppressing a noninactivating current conducted by the cardiac sodium channel [persistent sodium ion current (INa)]. Ranolazine has also been shown to inhibit the increased persist
Autor:
Joost H.G. Das, Marjan J. A. van Kempen, Martin B. Rook, Bobby P. C. Koeleman, Kristopher M. Kahlig, Linda Volkers, Dick Lindhout
Publikováno v:
The Journal of General Physiology
Generalized epilepsy with febrile seizures plus (GEFS+) is an early onset febrile epileptic syndrome with therapeutic responsive (a)febrile seizures continuing later in life. Dravet syndrome (DS) or severe myoclonic epilepsy of infancy has a complex