Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kristopher M. Depew"'
Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction
Autor:
Chaoyi Deng, Ramesh Reddy, Sam Tadayon, Kristopher M. Depew, Ming Xu, Hui Li, Benjamin S. Lane, Man Ding, Ruiheng Zhu
Publikováno v:
Organic Process Research & Development. 25:199-205
The development of a continuous manufacturing process for a hydrazine condensation reaction at high temperature is reported. This continuous process represents a safer approach to manufacture 3-phe...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8053679d1c5f4bf069763ce20da850d
https://doi.org/10.1021/acs.oprd.0c00424
https://doi.org/10.1021/acs.oprd.0c00424
Autor:
Michael Foley, Andre Lescarbeau, Martin R. Tremblay, Lombardy Richard John, Grogan Michael John, Andrew B. Hague, Kristopher M. Depew, Jimin Xiong, Joseph Helble, Priscilla L. White, Julian Adams, Brian C. Austad, Caroline D. Lory, Somarajan J. Nair, Stéphane Peluso, Lin-Chen Yu, Alfredo C. Castro, André B. Charette, Benjamin S. Lane, Jeanne Shaffer, Louis Grenier, James R. Porter, Matthew Campbell, Koney Nii O, Mark L. Behnke
Publikováno v:
Organic Process Research & Development. 20:786-798
The formation of the d-homocyclopamine ring system in IPI-926 is the key step in its semisynthesis and proceeds via a chemoselective cyclopropanation followed by a stereoselective acid-catalyzed carbocation rearrangement. In order to perform large-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9debb0b604cbda59d104def86c7642
https://doi.org/10.1021/acs.oprd.6b00048
https://doi.org/10.1021/acs.oprd.6b00048
Autor:
Martin Trudeau, Louis Grenier, Kristopher M. Depew, Daniel G. Genov, Alexandre Côté, Brian C. Austad, Lin-Chen Yu, Andre Lescarbeau, Theodore A. Martinot, Priscilla L. White, Joseph Helble, Somarajan J. Nair
Publikováno v:
Organic Process Research & Development. 19:1693-1702
A design of experiments (DoE) approach was taken to optimize purity and reaction yield of the final debenzylation and hydrochloride salt formation of IPI-926. The study involved a careful dissection of the different process steps to enable an indepen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303b6bb1bcb0f53d2408fcb4957573f0
https://doi.org/10.1021/acs.oprd.5b00214
https://doi.org/10.1021/acs.oprd.5b00214
Publikováno v:
Current Opinion in Chemical Biology. 14:412-420
The Hsp90 chaperone is a master regulator of the stability and activity of multiple oncoproteins such as Her2, Akt, Bcr-Abl, c-Kit, EGFR and mutant BRAF. The promise of inhibition of such a master regulator for cancer therapy is the potential to caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b5fef634d42d058e4820435e27ae97
https://doi.org/10.1016/j.cbpa.2010.03.019
https://doi.org/10.1016/j.cbpa.2010.03.019
Publikováno v:
Chemistry & Biology. 9:265-276
Through a correlation of the ability of small molecules to bind biological macromolecules and their ability to modulate cellular and organismal processes, chemistry can inform biology and vice versa. Diversity-oriented organic synthesis (DOS), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b13be409eb7ad9c82ff3bcab2c1863
https://doi.org/10.1016/s1074-5521(02)00099-6
https://doi.org/10.1016/s1074-5521(02)00099-6
Publikováno v:
Tetrahedron Letters. 41:289-292
Protected versions of (3R,5R)-5-hydroxypiperazic acid were synthesized enantioselectively in two novel ways. The first derives its chirality from D-glutamic acid while the second uses an Evans amination and a diastereoselective bromolactonization to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5cab2550fb40f6ff11f1b1e049f181d
https://doi.org/10.1016/s0040-4039(99)01958-9
https://doi.org/10.1016/s0040-4039(99)01958-9
Autor:
and Kristopher M. Depew, Jeffrey M. Schkeryantz, Samuel J. Danishefsky, Jonathan C. G. Woo, Phieng Siliphaivanh
Publikováno v:
Journal of the American Chemical Society. 121:11964-11975
A concise and efficient total synthesis of the acyl-CoA:cholesterol acyltransferase inhibitor gypsetin (1) is described. The route features a straightforward method for the introduction of a reverse prenyl group into the C2-position of an N-phthaloyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fb3d06017606f3b7ccae02dc079383
https://doi.org/10.1021/ja9925249
https://doi.org/10.1021/ja9925249
Publikováno v:
Proceedings of the National Academy of Sciences. 95:4327-4332
We present a helical unwinding assay for reversibly binding DNA ligands that uses closed circular DNA, topoisomerase I (Topo I), and two-dimensional agarose gel electrophoresis. Serially diluted Topo I relaxation reactions at constant DNA/ligand rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeacb5863f2d9ec36b0f993e165f040f
https://doi.org/10.1073/pnas.95.8.4327
https://doi.org/10.1073/pnas.95.8.4327
Autor:
Samuel J. Danishefsky, Kristopher M. Depew, Derek J. Denhart, Donald M. Crothers, Steven M. Zeman, Norihiro Ikemoto, Serge H. Boyer
Publikováno v:
Angewandte Chemie. 108:2972-2975
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c9fbaaa3156f4d0d2a19d20e29f3a8f
https://doi.org/10.1002/ange.19961082317
https://doi.org/10.1002/ange.19961082317
Autor:
Kristopher M. Depew, Derek J. Denhart, Steven M. Zeman, Norihiro Ikemoto, Donald M. Crothers, Samuel J. Danishefsky, Serge H. Boyer
Publikováno v:
Angewandte Chemie International Edition in English. 35:2797-2801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1b7c3575adfe068268a8363fcfea72f
https://doi.org/10.1002/anie.199627971
https://doi.org/10.1002/anie.199627971