Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kristopher K, Abney"'
Autor:
Yazen Alnouti, Corey R. Hopkins, Kristopher K. Abney, Nagsen Gautam, Krystian A. Kozek, Sushil Kumar, Swagat Sharma, C. David Weaver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:791-796
The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughp
Autor:
Kristopher K. Abney, Jacques Galipeau
Publikováno v:
The FEBS journalReferences. 288(13)
Mesenchymal stromal cells (MSCs) are non-hematopoietic cells that have been clinically explored as investigational cellular therapeutics for tissue injury regeneration and immune-mediated diseases. Their pharmaceutical properties arise from activatio
Autor:
J. Scott Daniels, Swagat Sharma, Joshua M. Wieting, Corey R. Hopkins, Kristopher K. Abney, Kevin Wickman, Anish K. Vadukoot, Thomas M. Bridges, Ryan D. Morrison, C. David Weaver
Publikováno v:
ACS Chemical Neuroscience. 8:1873-1879
The G protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiological processes and as potential targ
Autor:
John Scott Daniels, Allison Anderson, Corey R. Hopkins, Ezequiel Marron Fernandez de Velasco, Ryan D. Morrison, Kristopher K. Abney, Baovi N. Vo, Michael A. Benneyworth, Charles David Weaver, Kevin Wickman
Publikováno v:
British Journal of Pharmacology.
Background and purpose G protein-gated inwardly rectifying K+ (Kir 3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal Kir 3 channels consist of Kir 3.1 and Ki
Autor:
Kristopher K. Abney, Yu Du, Thomas M. Bridges, Michael Bubser, Craig W. Linsdley, Carrie K. Jones, Corey R. Hopkins, Ryan D. Morrison, J. Scott Daniels, C. David Weaver, Krystian A. Kozek, Kevin Wickman
Publikováno v:
ACS chemical neuroscience. 10(3)
G protein-gated inwardly-rectifying potassium (GIRK) channels are potassium-selective ion channels. As their name suggests, GIRK channels are effectors of G(i/o) G protein-couple receptors whereby activation of these GPCRs leads to increased GIRK cha
Autor:
Baovi N, Vo, Kristopher K, Abney, Allison, Anderson, Ezequiel, Marron Fernandez de Velasco, Michael A, Benneyworth, John Scott, Daniels, Ryan D, Morrison, Corey R, Hopkins, Charles David, Weaver, Kevin, Wickman
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: G protein‐gated inwardly rectifying K(+) (K(ir)3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal K(ir)3 channels consist of K(ir)3.
Autor:
Susan J. Ramos-Hunter, J. Shawn Goodwin, Kristopher K. Abney, Gary A. Sulikowski, Ian M. Romaine, C. David Weaver
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(36)
This study reports the synthesis and testing of a family of rhodamine pro-fluorophores and an enzyme capable of converting pro-fluorophores to Rhodamine 110. We prepared a library of simple N,N′-diacyl rhodamines and investigated porcine liver este
Autor:
Corey R. Hopkins, Krystian A. Kozek, Yu Du, Kristopher K. Abney, J. Scott Daniels, Thomas M. Bridges, Kevin Wickman, Craig W. Lindsley, C. David Weaver, Ryan D. Morrison, Michael Bubser, Carrie K. Jones
Publikováno v:
ACS Chemical Neuroscience. 10:2621-2621
Autor:
Kristian Kaufmann, Gary A. Sulikowski, C. David Weaver, Kristopher K. Abney, Craig W. Lindsley, Yu Du, Emily Days, Shaun R. Stauffer, Ian M. Romaine
Publikováno v:
ACS chemical neuroscience. 6(6)
Ion channels are critical for life, and they are targets of numerous drugs. The sequencing of the human genome has revealed the existence of hundreds of different ion channel subunits capable of forming thousands of ion channels. In the face of this