Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kristopher G Virga"'
Autor:
Christina Spry, Cristiano Macuamule, Zhiyang Lin, Kristopher G Virga, Richard E Lee, Erick Strauss, Kevin J Saliba
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54974 (2013)
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization. In this study,
Externí odkaz:
https://doaj.org/article/bec1316d7f524a58bec1071ea6c7fda6
Publikováno v:
Current medicinal chemistry. 26(28)
As a long-term degenerative disorder of the central nervous system that mostly affects older people, Parkinson’s disease is a growing health threat to our ever-aging population. Despite remarkable advances in our understanding of this disease, all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2b8b304d321a2eabe960a8952a70fb
https://pubmed.ncbi.nlm.nih.gov/30027839
https://pubmed.ncbi.nlm.nih.gov/30027839
Autor:
Alfonso Romero-Sandoval, Kristopher G. Virga, Carolina Moracho-Vilrriales, Perla Abigail Alvarado-Vazquez, Scott Asbill, Giuseppe Gumina, Alicia Bort
Publikováno v:
Molecular Pain
Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49729c22cfa0970c086411a56259d0d
https://pubmed.ncbi.nlm.nih.gov/28326930
https://pubmed.ncbi.nlm.nih.gov/28326930
This review discusses next-generation antibacterial agents developed using rational, or targeted, drug design strategies. The focus of this review is on small-molecule compounds that have been designed to bypass developing bacterial resistance, impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738bb24c680d999e4aeaa0368d5e7bc8
https://europepmc.org/articles/PMC5025264/
https://europepmc.org/articles/PMC5025264/
Autor:
Jaroslav Zajicek, Weimin Lin, David Mendel, Kyung Hee Kim, Kristopher G. Virga, Marvin J. Miller
Publikováno v:
The Journal of Organic Chemistry. 74:5941-5946
The tert-butyl N-hydroxycarbamate-derived nitroso reagent 1 reacted with N-Cbz-protected spirocyclic diene 2 to provide spirocycloadduct 3. Here we describe the efficient conversion of 3 into the novel carbocyclic nucleoside spironoraristeromycin 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::298e2d3f2c4c3cb66ac36b7b83f0f220
https://doi.org/10.1021/jo900877b
https://doi.org/10.1021/jo900877b
Autor:
Shigeru Chohnan, Brett R. Wenner, James R. Bain, Kristopher G. Virga, Richard E. Lee, Suzanne Jackowski, Robert Stevens, Yong-Mei Zhang, Charles O. Rock, Olga Ilkayeva, Christopher B. Newgard
Publikováno v:
Chemistry & Biology. 14:291-302
Coenzyme A (CoA) is the major acyl group carrier in intermediary metabolism. Hopantenate (HoPan), a competitive inhibitor of the pantothenate kinases, was used to chemically antagonize CoA biosynthesis. HoPan dramatically reduced liver CoA levels and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20728bc58e5126580e8f492fa52b3fb8
https://doi.org/10.1016/j.chembiol.2007.01.013
https://doi.org/10.1016/j.chembiol.2007.01.013
Autor:
Kevin J. Saliba, Kristopher G. Virga, Erick Strauss, Christina Spry, Cristiano J. Macuamule, Richard E. Lee, Zhiyang Lin
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54974 (2013)
PLoS ONE
PLoS ONE
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e174b7766776c339f5ee64eec2934e
http://europepmc.org/articles/PMC3566143?pdf=render
http://europepmc.org/articles/PMC3566143?pdf=render
Autor:
Ying Zhao, Mi-Kyung Yun, Kristopher G. Virga, Sourav Das, Richard E. Lee, Stephen W. White, Jianjun Qi
The increasing emergence of resistant bacteria drives us to design and develop new antimicrobial agents. Pursuant to that goal, a new targeting approach of the dihydropteroate synthase enzyme, which serves as the site of action for the sulfonamide cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2413c6fa61d1f07d5d21fd71fdf4fe
https://europepmc.org/articles/PMC3147184/
https://europepmc.org/articles/PMC3147184/
Autor:
Weimin, Lin, Kristopher G, Virga, Kyung-Hee, Kim, Jaroslav, Zajicek, David, Mendel, Marvin J, Miller
Publikováno v:
The Journal of organic chemistry. 74(16)
The tert-butyl N-hydroxycarbamate-derived nitroso reagent 1 reacted with N-Cbz-protected spirocyclic diene 2 to provide spirocycloadduct 3. Here we describe the efficient conversion of 3 into the novel carbocyclic nucleoside spironoraristeromycin 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e93c98e09dbdd88ef7d12aa1317f41a8
https://pubmed.ncbi.nlm.nih.gov/19601571
https://pubmed.ncbi.nlm.nih.gov/19601571
Autor:
Jianjun Qi, Richard E. Lee, Philip M. Potter, M. Jason Hatfield, Joanna S. Remack, Kristopher G. Virga, Mary K. Danks, K. Jin Yoon
Publikováno v:
Molecular cancer therapeutics. 5(6)
Enzyme-prodrug approaches to cancer therapy, theoretically, have the potential to mediate tumor-selective cytotoxicity. However, even if tumor-specific prodrug activation is achieved, enzyme-prodrug systems investigated thus far comprised a single en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56d7094737e536411c26434406594ee
https://pubmed.ncbi.nlm.nih.gov/16818517
https://pubmed.ncbi.nlm.nih.gov/16818517