Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kristopher Burkewitz"'
Autor:
Nikita Tsyba, Gaomin Feng, Lantana K. Grub, James P. Held, Adrianna M. Strozak, Kristopher Burkewitz, Maulik R. Patel
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106349- (2023)
Summary: Mutations in the mitochondrial genome (mtDNA) can be pathogenic. Owing to the multi-copy nature of mtDNA, wild-type copies can compensate for the effects of mutant mtDNA. Wild-type copies available for compensation vary depending on the muta
Externí odkaz:
https://doaj.org/article/eb30915a8efc4f3b8dbbe9a36ff2fad2
Autor:
James P Held, Gaomin Feng, Benjamin R Saunders, Claudia V Pereira, Kristopher Burkewitz, Maulik R Patel
Publikováno v:
eLife, Vol 11 (2022)
The mitochondrial unfolded protein response (UPRmt) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple pathways likely exist to modulate UPRmt. We discovered that the tRNA processing enzyme, homolog o
Externí odkaz:
https://doaj.org/article/c81b9865a2cf48a6b5e913ca67b984b5
Autor:
Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, Matthew S. Gill
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1695-1705 (2016)
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a library of bioactive l
Externí odkaz:
https://doaj.org/article/bcf733c1a23e4a328fb0ad6cb05baf2a
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34153 (2012)
Exposure of C. elegans to hypertonic stress-induced water loss causes rapid and widespread cellular protein damage. Survival in hypertonic environments depends critically on the ability of worm cells to detect and degrade misfolded and aggregated pro
Externí odkaz:
https://doaj.org/article/6bdbdad2d13c4565949f826f61072fbb
Publikováno v:
Biochemical Society Transactions. 50:1389-1402
Advances in public health have nearly doubled life expectancy over the last century, but this demographic shift has also changed the landscape of human illness. Today, chronic and age-dependent diseases dominate the leading causes of morbidity and mo
Autor:
Olivia Triplett, Kristopher Burkewitz, Charlotte A. Kelley, William B. Mair, Erin J. Cram, Samyukta Mallick
Publikováno v:
Cytoskeleton (Hoboken)
Actomyosin networks are organized in space, direction, size, and connectivity to produce coordinated contractions across cells. We use the C. elegans spermatheca, a tube composed of contractile myoepithelial cells, to study how actomyosin structures
Autor:
James P Held, Gaomin Feng, Benjamin R Saunders, Claudia V Pereira, Kristopher Burkewitz, Maulik R Patel
Publikováno v:
eLife. 11
The mitochondrial unfolded protein response (UPRmt) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple pathways likely exist to modulate UPRmt. We discovered that the tRNA processing enzyme, homolog o
Autor:
Sneha Dutta, Erin J. Cram, Michael J. Steinbaugh, Charlotte A. Kelley, William B. Mair, Kristopher Burkewitz
Functional crosstalk between organelles is critical for maintaining cellular homeostasis. Individually, dysfunction of both endoplasmic reticulum (ER) and mitochondria have been linked to cellular and organismal aging, but little is known about how m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01675871f4a72f2e22b04f062d754c6f
https://doi.org/10.1101/2020.01.14.906693
https://doi.org/10.1101/2020.01.14.906693
Autor:
Kristopher Burkewitz, Jason M. Held, William B. Mair, Matthew S. Gill, Jo-Hao Ho, Laura M. Bohn, Tiffany K. Kaul, Mark Lucanic, Pedro Rodrigues
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1695-1705 (2016)
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1695-1705 (2016)
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a library of bioactive l