Výsledky vyhledávání - "Kristopher A Kerns"

Akademický článek

Rapamycin rejuvenates oral health in aging mice

Autor: Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein

Publikováno v: eLife, Vol 9 (2020)

Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodo

Externí odkaz: https://doaj.org/article/8584545bd4ac42a89c41f22e47a2deac

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Akademický článek

Ultrasmall epibiont Nanosynbacter lyticus strain TM7x and host bacteria transcriptional activity after initial host parasitism

Autor: Erik L Hendrickson, Batbileg Bor, Kristopher A. Kerns, Lujia Cen, Wenyuan Shi, Xuesong He, Jeffrey S McLean

Publikováno v: Journal of Oral Microbiology, Vol 16, Iss 1 (2024)

ABSTRACTBackground Oral Saccharibacteria Nanosynbacter lyticus strain TM7× lives as an ultrasmall epibiont on the surface of its host, Schaalia odontolytica strain XH001. Establishing this interaction is a poorly understood multi-step process. The r

Externí odkaz: https://doaj.org/article/3fb0581810584d72a87ac0566fc92358

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Akademický článek

Strain-Level Variation and Diverse Host Bacterial Responses in Episymbiotic Saccharibacteria

Autor: Jie Nie, Daniel R. Utter, Kristopher A. Kerns, Eleanor I. Lamont, Erik L. Hendrickson, Jett Liu, Tingxi Wu, Xuesong He, Jeffrey McLean, Batbileg Bor

Publikováno v: mSystems, Vol 7, Iss 2 (2022)

ABSTRACT Saccharibacteria (TM7), which are obligate episymbionts growing on the surface of host bacteria, may play an important role in oral disease, such as periodontitis (1, 2). As TM7 is a newly cultured lineage of bacteria, its research is limite

Externí odkaz: https://doaj.org/article/aff124e069de41ac8c5f1f35887a6fae

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Transcriptome of Epibiont Saccharibacteria Nanosynbacter lyticus Strain TM7x During the Establishment of Symbiosis

Autor: Erik L. Hendrickson, Batbileg Bor, Kristopher A. Kerns, Eleanor I. Lamont, Yunjie Chang, Jun Liu, Lujia Cen, Fabian Schulte, Markus Hardt, Wenyuan Shi, Xuesong He, Jeffrey S. McLean

Publikováno v: J Bacteriol

SaccharibacteriaiNanosynbacter lyticus/istrain TM7x is a member of the broadly distributed candidate phylum radiation. These bacteria have ultrasmall cell sizes, have reduced genomes, and live as epibionts on the surfaces of other bacteria. The mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac82db11f549d881f20441956cc5686
https://doi.org/10.1128/jb.00112-22

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Draft Genome Sequences of Nine ' Candidatus Nanosynbacter sp. HMT-352' Strains Cultured from the Human Oral Cavity

Autor: Jett Liu, Daniel R. Utter, Jie Nie, Kristopher A. Kerns, Eleanor I. Lamont, Erik L. Hendrickson, Xiaoyan Wang, Jeffrey S. McLean, Xuesong He, Batbileg Bor

Publikováno v: Microbiology Resource Announcements. 11

Here, we report draft genome sequences for nine strains of “ Candidatus Nanosynbacter sp. HMT-352.” These strains and their sequences were used to interrogate strain-level variations in host range, gene content, and growth dynamics among the phyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3263d640a9cb584a69fc3f498a642472
https://doi.org/10.1128/mra.00403-22

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Modified SHI medium supports growth of a disease‐state subgingival polymicrobial community in vitro

Autor: Archita Gadkari, Thao T. To, Kristopher A. Kerns, Xuesong He, Georgios A. Kotsakis, Diane M. Daubert, Jeffrey S. McLean, Batbileg Bor, Eleanor I. Lamont

Publikováno v: Molecular Oral Microbiology

Developing a laboratory model of oral polymicrobial communities is essential for in vitro studies of the transition from healthy to diseased oral plaque. SHI medium is an enriched growth medium capable of supporting in vitro biofilms with similar div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8012468182b55b07134fe77f981f3f39
http://europepmc.org/articles/PMC7984074

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Transcriptome of epibiont Saccharibacteria Nanosynbacter lyticus strain TM7x during establishment of symbiosis

Autor: Erik L Hendrickson, Batbileg Bor, Kristopher A. Kerns, Eleanor I. Lamont, Yunjie Chang, Jun Liu, Lujia Cen, Wenyuan Shi, Xuesong He, Jeffrey S McLean

Saccharibacteria Nanosynbacter lyticus strain TM7x is a member of the broadly distributed Candidate Phylum Radiation. These bacteria have ultrasmall cell size, reduced genomes and live as epibionts on the surface of other bacteria. The mechanisms by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c8023591e4a9fac33376ae04edd6582
https://doi.org/10.1101/2022.03.25.485537

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Human variation in gingival inflammation

Autor: Dandan Chen, Kristopher A. Kerns, Shatha Bamashmous, Camille Zenobia, Richard P. Darveau, Harsh M. Trivedi, Georgios A. Kotsakis, Jeffrey S. McLean, Brian G. Leroux

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Experimental gingivitis studies where dental hygiene is withheld from select teeth, allowing natural bacterial accumulation, provide a unique opportunity to study the reversible transition from health to inflammatory disease in humans. L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e310a6f353884575e66255fa63cec155
http://europepmc.org/articles/PMC8271746

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