Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Kristoffer Vitting‐Seerup"'
Autor:
Dylan Scott Lykke Harwood, Vilde Pedersen, Nicolai Schou Bager, Ane Yde Schmidt, Tobias Overlund Stannius, Aušrinė Areškevičiūtė, Knud Josefsen, Dorte Schou Nørøxe, David Scheie, Hannah Rostalski, Maya Jeje Schuang Lü, Alessio Locallo, Ulrik Lassen, Frederik Otzen Bagger, Joachim Weischenfeldt, Dieter Henrik Heiland, Kristoffer Vitting-Seerup, Signe Regner Michaelsen, Bjarne Winther Kristensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by chemotherapy and radiotherapy. Malignant cells escape surgical resection by migrating into the surr
Externí odkaz:
https://doaj.org/article/c9a8d9f57fc34c07b292a1cad2634555
Autor:
Christina Bligaard Pedersen, Benito Campos, Lasse Rene, Helene Scheel Wegener, Neeraja M. Krishnan, Binay Panda, Kristoffer Vitting‐Seerup, Maria Rossing, Frederik Otzen Bagger, Lars Rønn Olsen
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 606-619 (2024)
Molecular subtyping is essential to infer tumor aggressiveness and predict prognosis. In practice, tumor profiling requires in‐depth knowledge of bioinformatics tools involved in the processing and analysis of the generated data. Additionally, data
Externí odkaz:
https://doaj.org/article/91af8075ca0347618bf363e33adca13d
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Through alternative splicing, most human genes produce multiple isoforms in a cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing is essential for development, diseases, and their treatment
Externí odkaz:
https://doaj.org/article/672214d891ac4b0d9ea1b70e8924af38
Publikováno v:
F1000Research, Vol 10 (2022)
Alternative splicing produces multiple functional transcripts from a single gene. Dysregulation of splicing is known to be associated with disease and as a hallmark of cancer. Existing tools for differential transcript usage (DTU) analysis either lac
Externí odkaz:
https://doaj.org/article/abc8ca091dbd413aae4834079746788c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/b34d42d0819e47c5b8becfd23f27648b
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background 5′-end sequencing assays, and Cap Analysis of Gene Expression (CAGE) in particular, have been instrumental in studying transcriptional regulation. 5′-end methods provide genome-wide maps of transcription start sites (TSSs) wit
Externí odkaz:
https://doaj.org/article/bdbbeebf2d5e4f4d8851d8276294b5d3
Autor:
Jette Bornholdt, Christa Broholm, Yun Chen, Alfredo Rago, Stine Sloth, Jakob Hendel, Cathrine Melsæther, Christina V. Müller, Maria Juul Nielsen, Jesper Strickertsson, Lars Engelholm, Kristoffer Vitting-Seerup, Kim B. Jensen, Adam Baker, Albin Sandelin
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
The specific effects of administering live probiotics in the human gut are not well characterized. To this end, we investigated the immediate effect of Lactobacillus rhamnosus GG (LGG) in the jejunum of 27 healthy volunteers 2 h after ingestion using
Externí odkaz:
https://doaj.org/article/9243eb2759cc40ca901701ba70e54b10
Autor:
Mette Boyd, Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen, Kim Bak Jensen, Ismail Gögenur, Peter Thielsen, Jakob Benedict Seidelin, Ole Haagen Nielsen, Jacob Tveiten Bjerrum, Albin Sandelin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Many SNPs associated with inflammatory bowel disease are located in non-coding genomic regions. Here, the authors perform CAGE-sequencing on descending colon biopsies of Crohn’s disease and ulcerative colitis patients to map transcription start sit
Externí odkaz:
https://doaj.org/article/e32e0b001f3f40cfa76d4515cf61a036
Autor:
Mikkel Staberg, Rikke Darling Rasmussen, Signe Regner Michaelsen, Henriette Pedersen, Kamilla Ellermann Jensen, Mette Villingshøj, Jane Skjoth‐Rasmussen, Jannick Brennum, Kristoffer Vitting‐Seerup, Hans Skovgaard Poulsen, Petra Hamerlik
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 406-420 (2018)
Glioblastoma (GBM) ranks among the most lethal cancers, with current therapies offering only palliation. Inter‐ and intrapatient heterogeneity is a hallmark of GBM, with epigenetically distinct cancer stem‐like cells (CSCs) at the apex. Targeting
Externí odkaz:
https://doaj.org/article/398d29935a7f40d8aa830b02552b115b
Autor:
Thomas Urup, Line Mærsk Staunstrup, Signe Regner Michaelsen, Kristoffer Vitting-Seerup, Marc Bennedbæk, Anders Toft, Lars Rønn Olsen, Lars Jønson, Shohreh Issazadeh-Navikas, Helle Broholm, Petra Hamerlik, Hans Skovgaard Poulsen, Ulrik Lassen
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Bevacizumab combined with chemotherapy produces clinical durable response in 25–30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this study was to investi
Externí odkaz:
https://doaj.org/article/d6cd520ea2664653a177429de6ebebb1