Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Kristoffer T G Rigbolt"'
1
Akademický článek
A liver secretome gene signature-based approach for determining circulating biomarkers of NAFLD severity.
Autor: Christoffer A Hagemann, Christian Legart, Mathias B Møllerhøj, Martin R Madsen, Henrik H Hansen, Merete J Kønig, Frederik Helgstrand, Flemming P Hjørne, Anders Toxværd, Jill L Langhoff, Urd L Kielgast, Lise L Gluud, Helene Ægidius, Kristoffer T G Rigbolt, Tina Vilsbøll, Jacob Jelsing, Filip K Knop
Publikováno v: PLoS ONE, Vol 17, Iss 10, p e0275901 (2022)
Non-invasive biomarkers of non-alcoholic fatty liver disease (NAFLD) supporting diagnosis and monitoring disease progression are urgently needed. The present study aimed to establish a bioinformatics pipeline capable of defining and validating NAFLD
Externí odkaz: https://doaj.org/article/412f757f7a7548c281835b15666a4a54
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2
Akademický článek
Phosphorylation site dynamics of early T-cell receptor signaling.
Autor: Lily A Chylek, Vyacheslav Akimov, Jörn Dengjel, Kristoffer T G Rigbolt, Bin Hu, William S Hlavacek, Blagoy Blagoev
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104240 (2014)
In adaptive immune responses, T-cell receptor (TCR) signaling impacts multiple cellular processes and results in T-cell differentiation, proliferation, and cytokine production. Although individual protein-protein interactions and phosphorylation even
Externí odkaz: https://doaj.org/article/ed9ed38ade6f472c88b5b5547b20a66a
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3
Akademický článek
Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease
Autor: Frederikke E. Sembach, Helene M. Ægidius, Lisbeth N. Fink, Thomas Secher, Annemarie Aarup, Jacob Jelsing, Niels Vrang, Bo Feldt-Rasmussen, Kristoffer T. G. Rigbolt, Jens C. Nielsen, Mette V. Østergaard
Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
The current understanding of molecular mechanisms driving diabetic kidney disease (DKD) is limited, partly due to the complex structure of the kidney. To identify genes and signalling pathways involved in the progression of DKD, we compared kidney co
Externí odkaz: https://doaj.org/article/81d68d895ca048628b90770834252305
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4
Non‐alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion
Autor: Malte P. Suppli, Peter Lykke Eriksen, Kristoffer T. G. Rigbolt, Sanne Skovgård Veidal, Hendrik Vilstrup, Karen Louise Thomsen, Fillip Krag Knop, Michael Sørensen, Sara Heebøll
Publikováno v: Eriksen, P L, Vilstrup, H, Rigbolt, K, Suppli, M P, Sørensen, M, Heebøll, S, Veidal, S S, Knop, F K & Thomsen, K L 2019, ' Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion ', Liver International, vol. 39, no. 11, pp. 2094-2101 . https://doi.org/10.1111/liv.14205
Background & Aims: We recently showed that the functional capacity for ureagenesis is deficient in non-alcoholic fatty liver disease (NAFLD) patients. The aim of this study was to assess expression of urea cycle-related genes to elucidate a possible
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b6eda02378f2bd02db4dc62ba621a0
https://doi.org/10.1111/liv.14205
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5
Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice
Autor: Mette Simone Aae Madsen, Jacob Bak Holm, Morten Otto Alexander Sommer, Jacob Jelsing, Niels Vrang, Katrine Fabricius, Henrik H. Hansen, Kristoffer T. G. Rigbolt, Pernille Wismann, Albert Pallejà, Martin Tue Mikkelsen, Henrik Nielsen
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Madsen, M S A, Holm, J B, Pallejà, A, Wismann, P, Fabricius, K, Rigbolt, K, Mikkelsen, M T, Sommer, M O A, Jelsing, J, Nielsen, H B, Vrang, N & Hansen, H H 2019, ' Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice ', Scientific Reports, vol. 9, 15582 . https://doi.org/10.1038/s41598-019-52103-x
Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in the treatment of type 2 diabetes, obesity and intestinal diseases. As gut microbial imbalan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537a11f9d89e8c4a95692e7d1063f6e8
https://doi.org/10.1038/s41598-019-52103-x
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6
Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis
Autor: Matthew P. Gillum, Michael Feigh, Kirstine S Tølbøl, Niels Vrang, Andre Broermann, Henrik H. Hansen, Jacob Jelsing, Tanja Schönberger, Sanne Skovgård Veidal, Jörg F. Rippmann, Birgit Stierstorfer, Kristoffer T. G. Rigbolt
Publikováno v: Tolbol, K S, Stierstorfer, B, Rippmann, J F, Veidal, S S, Rigbolt, K T G, Schoenberger, T, Gillum, M P, Hansen, H H, Vrang, N, Jelsing, J, Feigh, M & Broermann, A 2019, ' Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis ', Digestive Diseases and Sciences, vol. 64, no. 5, pp. 1238-1256 . https://doi.org/10.1007/s10620-018-5395-7
Digestive Diseases and Sciences
Background There is a marked need for improved animal models of nonalcoholic steatohepatitis (NASH) to facilitate the development of more efficacious drug therapies for the disease. Methods Here, we investigated the development of fibrotic NASH in ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a782867cdcd19d4b6de84230f23e7136
https://curis.ku.dk/portal/da/publications/disease-progression-and-pharmacological-intervention-in-a-nutrientdeficient-rat-model-of-nonalcoholic-steatohepatitis(dee0b88d-1701-4453-858d-54a932f5a777).html
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7
Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways
Autor: Christina Christoffersen, Veidal Sanne S, Kristoffer T. G. Rigbolt, Jacob Jelsing, Maria Kristiansen
Publikováno v: Lipids.
Simple steatosis is the hallmark of nonalcoholic fatty liver disease, with lipid accumulating as either microvesicular or macrovesicular lipid droplets within hepatocytes. The present study used a combination of laser capture microdissection and RNAs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf5486aa978c514408667c9c2b6fd93
https://doi.org/10.1002/lipd.12121
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8
Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss
Autor: Jacob Jelsing, Philip J. Pedersen, Stefan Theis, Uwe Schwahn, Thorsten Schmidt, Niels Vrang, Anders Hay-Schmidt, Maria Luisa Fernandez-Cachon, Kristoffer T. G. Rigbolt, Henrik H. Hansen, Thomas Hübschle, Mechthilde Falkenhahn, Pernille Barkholt
Publikováno v: Barkholt, P, Rigbolt, K T G, Falkenhahn, M, Huebschle, T, Schwahn, U, Fernandez-Cachon, M L, Schmidt, T, Theis, S, Hansen, H H, Hay-Schmidt, A, Pedersen, P J, Vrang, N & Jelsing, J 2019, ' Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss ', Scientific Reports, vol. 9, 16161 . https://doi.org/10.1038/s41598-019-52257-8
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
The central mechanisms underlying the marked beneficial metabolic effects of bariatric surgery are unclear. Here, we characterized global gene expression in the hypothalamic arcuate nucleus (Arc) in diet-induced obese (DIO) rats following Roux-en-Y g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42436930ca18a59a382e983a69b26808
https://curis.ku.dk/ws/files/232004498/Global_transcriptome_analysis_of_rat_hypothalamic_arcuate_nucleus_demonstrates_reversal_of_hypothalamic_gliosis_following_surgically_and_diet_induced_weight_loss.pdf
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9
Clinical Features and Hepatic Molecular Characteristics in NAFLD and NASH Patients Compared to Normal Weight Healthy Individuals
Autor: Filip K. Knop, Jonatan I. Bagger, Jacob Jelsing, Niels Vrang, Sanne Skovgård Veidal, Kristoffer T. G. Rigbolt, Sara Heebøll, Mia Demant, Malte P. Suppli, Tina Vilsbøll, Asger Lund
Publikováno v: Diabetes. 67
The molecular events underlying the development and progression of nonalcoholic fatty liver disease (NAFLD), covering a wide spectrum from simple hepatic steatosis to the more aggressive inflammatory manifestation, nonalcoholic steatohepatitis (NASH)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cc658b22453e5956e86eb322d99fc63
https://doi.org/10.2337/db18-260-lb
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10
Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake
Autor: Jacob Jelsing, Louise S. Dalbøge, Knud J. Jensen, Birgitte Holst, Søren Blok van Witteloostuijn, Søren L. Pedersen, Niels Vrang, Kristoffer T. G. Rigbolt, Jakob E. Rasmussen
Publikováno v: Journal of Peptide Science. 21:85-94
Neuromedin U (NMU) is a 25 amino acid peptide expressed and secreted in the brain and gastrointestinal tract. Data have shown that peripheral administration of human NMU decreases food intake and body weight and improves glucose tolerance in mice, su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a7b3cac04181bead27f8717c9b4f1e9
https://doi.org/10.1002/psc.2727
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