Inhibition of succinate dehydrogenase activity impairs human T cell activation and function

Autor: Claudia Nastasi, Andreas Willerlev-Olsen, Kristoffer Dalhoff, Shayne L. Ford, Anne-Sofie Østergaard Gadsbøll, Terkild Brink Buus, Maria Gluud, Morten Danielsen, Thomas Litman, Charlotte Mennè Bonefeld, Carsten Geisler, Niels Ødum, Anders Woetmann

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phosphory

Externí odkaz: https://doaj.org/article/5e71106e1a1b4c9d9bd7951b5e678565

Using TKTD Models in Combination with In Vivo Enzyme Inhibition Assays to Investigate the Mechanisms behind Synergistic Interactions across Two Species

Autor: Kristoffer Dalhoff, Emil Boesen, Nina Cedergreen, Giulia Bellisai, Laia Herrero-Nogareda

Publikováno v: Environmental Science & Technology. 55:13990-13999

The aim of this study is to compare the azole synergy across an insect, Chironomus riparius, and a crustacean species, Daphnia magna. We use a combination of in vivo measurements of cytochrome P450 monooxygenase (CYP) biotransformation potential and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e327056610a2e424ad660d9087cad9c6
https://doi.org/10.1021/acs.est.1c02222

Linking Morphology, Toxicokinetic, and Toxicodynamic Traits of Aquatic Invertebrates to Pyrethroid Sensitivity

Autor: Nina Cedergreen, Bjarne W. Strobel, Kristoffer Dalhoff, Andreas Focks, Jes J. Rasmussen, Anna Magdalene Bruun Hansen

Publikováno v: Environmental science & technology 54 (2020) 9
Environmental science & technology, 54(9), 5687-5699
Dalhoff, K, Hansen, A M B, Rasmussen, J J, Focks, A, Strobel, B W & Cedergreen, N 2020, ' Linking morphology, toxicokinetic and toxicodynamic traits of aquatic invertebrates to pyrethroid sensitivity ', Environmental Science & Technology (Washington), vol. 54, pp. 5687-5699 . https://doi.org/10.1021/acs.est.0c00189

Pyrethroid insecticides are known to be highly toxic to most aquatic nontarget organisms, but little is known about the mechanisms causing some species to be highly sensitive while others are hardly affected by the pyrethroids. The aim of the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1020fb11aa54e9624ee590109a20dd53
https://doi.org/10.1021/acs.est.0c00189

Determining lower threshold concentrations for synergistic effects

Autor: Katrine Banke Nørgaard, Nina Cedergreen, Kristoffer Dalhoff, Andreas Kretschmann, Maj-Britt Andersen Bjergager, Philipp Mayer

Publikováno v: Aquatic Toxicology. 182:79-90

Though only occurring rarely, synergistic interactions between chemicals in mixtures have long been a point of focus. Most studies analyzing synergistic interactions used unrealistically high chemical concentrations. The aim of the present study is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a891d195de14797d48fd724948c7da0a
https://doi.org/10.1016/j.aquatox.2016.10.020

Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions

Autor: Kai Bester, Nina Cedergreen, Janna Kuhlmann, Kristoffer Dalhoff, Andreas Kretschmann, Ulla E. Bollmann

Publikováno v: Kuhlmann, J, Kretschmann, A C, Bester, K, Bollmann, U E, Dalhoff, K & Cedergreen, N 2019, ' Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide α-cypermethrin in Chironomus riparius : Investigating the importance of toxicokinetics and enzyme interactions ', Chemosphere, vol. 225, pp. 166-173 . https://doi.org/10.1016/j.chemosphere.2019.03.023

The fungicide imazalil is a chiral compound with one R- and one S-enantiomer. Enantiomers, while having the same chemical properties, can differ in their biological activity expressed as efficacy/toxicity as well as in their degradation kinetics and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e460c3746fc3d88041716f2f0ed7443
https://pubmed.ncbi.nlm.nih.gov/30875499