Výsledky vyhledávání - "Kristoff T. Homan"

Akademický článek

Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor

Autor: Kristoff T. Homan, Emily Wu, Alessandro Cannavo, Walter J. Koch, John J. G. Tesmer

Publikováno v: Molecules, Vol 19, Iss 10, Pp 16937-16949 (2014)

G protein-coupled receptor kinases (GRKs) have been implicated in human diseases ranging from heart failure to diabetes. Previous studies have identified several compounds that selectively inhibit GRK2, such as paroxetine and balanol. Far fewer selec

Externí odkaz: https://doaj.org/article/2033a9864a144175bf8b70ccff2b629f

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Imaging the Alternatively Spliced D Domain of Tenascin C in a Preclinical Model of Inflammatory Bowel Disease

Autor: Liang Zhang, Yuzhen Wang, Kristoff T. Homan, Stephanie M. Gaudette, Andrew J. McCluskey, Ying Chan, Joanne Murphy, Mary Abdalla, Christine M. Nelson, Victor Z. Sun, Jamie E. Erickson, Heather L. Knight, Anca Clabbers, Annette J. Schwartz Sterman, Soumya Mitra

Publikováno v: Molecular Imaging and Biology.

Purpose To image colon-expressed alternatively spliced D domain of tenascin C in preclinical colitis models using near infrared (NIR)-labeled targeted molecular imaging agents. Procedures. A human IgG1 with nanomolar binding affinity specific to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0935a45f8f5735a78c241899058544f6
https://doi.org/10.1007/s11307-022-01758-6

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Imaging the Alternatively Spliced D Domain of Tenascin C in Preclinical Models of Inflammatory Bowel Disease

Autor: Christine M. Nelson, Heather Knight, Jamie Erickson, Bradford L. McRae, Victor Sun, Annette J. Schwartz Sterman, Stephanie M. Gaudette, Grace Lynch, Kristoff T. Homan, Calvin S. Pohl, Sahana Bose, Liang Zhang, Soumya Mitra

Purpose To image colon-expressed alternatively spliced D domain of tenascin C in preclinical colitis models using near infrared (NIR) labeled targeted molecular imaging agents.Methods Human IgG and scFv fusion proteins specific to the alternatively s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7d2bc8d2a564fbddc2e3890916e5d33
https://doi.org/10.21203/rs.3.rs-984872/v1

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Akademický článek

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

Autor: Anthony W Azevedo, Thuy Doan, Hormoz Moaven, Iza Sokal, Faiza Baameur, Sergey A Vishnivetskiy, Kristoff T Homan, John JG Tesmer, Vsevolod V Gurevich, Jeannie Chen, Fred Rieke

Publikováno v: eLife, Vol 4 (2015)

Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin. Timely rhodopsin desensitization depends on phosphorylation and arrestin binding, which quenches

Externí odkaz: https://doaj.org/article/4edccd85553d48d8a0ead6c6fbec1158

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Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2–Gβ1γ2 Complex

Autor: John J.G. Tesmer, Osvaldo Cruz-Rodríguez, Yaoxin Li, Zhan Chen, Kristoff T. Homan, Pei Yang

Publikováno v: Biochemistry. 55:2841-2848

Interactions between proteins and cell membranes are critical for biological processes such as transmembrane signaling, and specific components of the membrane may play roles in helping to organize or mandate particular conformations of both integral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39c61f19c13ed04a9492908511014ba
https://doi.org/10.1021/acs.biochem.6b00354

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Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

Autor: Jessica Waninger-Saroni, Kelly M. Larimore, Paul D. Kirchhoff, Joseph Y. Cheung, Kristoff T. Homan, Osvaldo Cruz-Rodríguez, Helen V. Waldschmidt, John J.G. Tesmer, Marilyn C. Cato, Jianliang Song, Alessandro Cannavo, Scott D. Larsen, Walter J. Koch

Publikováno v: Journal of Medicinal Chemistry. 59:3793-3807

G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases (GRKs), some of which have been implicated in heart failure. GSK180736A, developed as a Rho-ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d76f3119d086fa1097fdb72ed05ea
https://doi.org/10.1021/acs.jmedchem.5b02000

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G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro

Autor: Vsevolod V. Gurevich, Sergey A. Vishnivetskiy, Sayaka Inagaki, Kristoff T. Homan, John J.G. Tesmer, Jim White, Rodolfo Ghirlando, Reinhard Grisshammer

Publikováno v: Biochemistry

G protein-coupled receptor kinases (GRKs) play an important role in the desensitization of G protein-mediated signaling of G protein-coupled receptors (GPCRs). The level of interest in mapping their phosphorylation sites has increased because recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9798d98cd2787be8301f9c9b04edb3e
http://europepmc.org/articles/PMC4512254

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Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

Autor: Marilyn C. Cato, Osvaldo Cruz-Rodríguez, Alessandro Cannavo, Walter J. Koch, Joseph Y. Cheung, Kristoff T. Homan, Scott D. Larsen, Helen V. Waldschmidt, Jianliang Song, Michael W. Wilson, John J.G. Tesmer

In heart failure, the β-adrenergic receptors (βARs) become desensitized and uncoupled from heterotrimeric G proteins. This process is initiated by G protein-coupled receptor kinases (GRKs), some of which are upregulated in the failing heart, making

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc95ad4ec5e668167ab16bfdd42fafb
http://hdl.handle.net/11588/732638

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Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor

Autor: John J.G. Tesmer, Walter J. Koch, Alessandro Cannavo, Emily Wu, Kristoff T. Homan

Publikováno v: Molecules (Basel, Switzerland)
Molecules, Vol 19, Iss 10, Pp 16937-16949 (2014)
Molecules
Volume 19
Issue 10
Pages 16937-16949

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f921a9e7b9067dabea92d0f83177b76
http://europepmc.org/articles/PMC4621012

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Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

Autor: John J.G. Tesmer, Kristoff T. Homan

Publikováno v: ACS Chemical Biology

Small molecules that inhibit the protein kinase A, G, and C (AGC) family of serine/threonine kinases can exert profound effects on cell homeostasis and thereby regulate fundamental processes such as heart rate, blood pressure, and metabolism, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80504b848857c402253fd1f89431382
http://europepmc.org/articles/PMC4301174

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