Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Kristofer J Thurecht"'
Autor:
Michael Agrez, Christopher Chandler, Kristofer J. Thurecht, Nicholas L. Fletcher, Feifei Liu, Gayathri Subramaniam, Christopher B. Howard, Stephen Parker, Darryl Turner, Justyna Rzepecka, Gavin Knox, Anastasia Nika, Andrew M. Hall, Hayley Gooding, Laura Gallagher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The identification of adjuvants to improve vaccination efficacy is a major unmet need. One approach is to augment the functionality of dendritic cells (DCs) by using Toll-like receptor-9 (TLR9) agonists such as cytosine-phosphate-guanine oli
Externí odkaz:
https://doaj.org/article/7a51c439ab39409a885cbdbbf60e0eef
Autor:
Michael Agrez, Christopher Chandler, Kristofer J. Thurecht, Nicholas L. Fletcher, Feifei Liu, Gayathri Subramaniam, Christopher B. Howard, Benjamin Blyth, Stephen Parker, Darryl Turner, Justyna Rzepecka, Gavin Knox, Anastasia Nika, Andrew M. Hall, Hayley Gooding, Laura Gallagher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Cancers and autoimmune diseases commonly co-exist and immune checkpoint inhibitor therapy (ICI) exacerbates autoimmune pathologies. We recently described a lipidic peptide, designated IK14004, that promotes expansion of immunosuppressive T r
Externí odkaz:
https://doaj.org/article/e0f0af9605974d5ea5748b35c3c11dc8
Autor:
Xinying Jia, Yanni K.-Y. Chin, Alan H. Zhang, Theo Crawford, Yifei Zhu, Nicholas L. Fletcher, Zihan Zhou, Brett R. Hamilton, Martin Stroet, Kristofer J. Thurecht, Mehdi Mobli
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Head-to-tail macrocyclization of proteins and peptides can increase their structural stability, however, potential polymerization can lead to reduced yields. Here, the authors report the engineering of self-cyclizing ‘autocyclase’ proteins to gen
Externí odkaz:
https://doaj.org/article/e22b7329d2fa42c78900ee527f8a1241
Autor:
Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1389 (2023)
Despite the clinical benefits that chemotherapeutics has had on the treatment of breast cancer, drug resistance remains one of the main obstacles to curative cancer therapy. Nanomedicines allow therapeutics to be more targeted and effective, resultin
Externí odkaz:
https://doaj.org/article/a8c8f24e479e4aa4a3f09886fa4d3643
Autor:
Maria E. Lund, Christopher B. Howard, Kristofer J. Thurecht, Douglas H. Campbell, Stephen M. Mahler, Bradley J. Walsh
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glypican-1 is a heparan sulfate proteoglycan that is overexpressed in prostate cancer (PCa), and a variety of solid tumors. Importantly, expression is restricted in normal tissue, making it an ideal tumor targeting antigen. Since
Externí odkaz:
https://doaj.org/article/1668823008e34a798cd55eef76770f0d
Autor:
Gary J Cowin, Karine Mardon, Zachary H. Houston, Rajiv Bhalla, Damion H. R. Stimson, Kristofer J. Thurecht, Ian M. Brereton
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Efficacy of diagnostics and therapeutics for brain tumours can be modulated by vascular delivery and blood brain barrier permeability. Simultaneous dynamic gadolinium MR-PET enables independent assessment of vascular delivery and blood brain barrier
Externí odkaz:
https://doaj.org/article/2285bb4d139f442aa000e0a8b53162b4
Autor:
Mei-Chun Yeh, Brian W. C. Tse, Nicholas L. Fletcher, Zachary H. Houston, Maria Lund, Marianna Volpert, Chelsea Stewart, Kamil A. Sokolowski, Varinder Jeet, Kristofer J. Thurecht, Douglas H. Campbell, Bradley J. Walsh, Colleen C. Nelson, Pamela J. Russell
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Purpose Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth,
Externí odkaz:
https://doaj.org/article/2ef2c8e3d8664d7a8617ef5010ba309f
Autor:
Zachary H. Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B. Howard, Nicholas L. Fletcher, Adrian V. Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W. Boyd, Stephen M. Mahler, Linda J. Richards, Frank Caruso, Kristofer J. Thurecht
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 727-738 (2020)
Externí odkaz:
https://doaj.org/article/3fb1a902064e45d0828820d915363b4e
Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma
Autor:
Taskeen Iqbal Janjua, Yuxue Cao, Aria Ahmed-Cox, Aun Raza, Md Moniruzzaman, Dewan Taslima Akhter, Nicholas L. Fletcher, Maria Kavallaris, Kristofer J. Thurecht, Amirali Popat
Publikováno v:
Journal of Controlled Release. 357:161-174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869d9a994271434fb0f56f31c35614fe
https://doi.org/10.1016/j.jconrel.2023.03.040
https://doi.org/10.1016/j.jconrel.2023.03.040
Autor:
Karishma T. Mody, Bing Zhang, Xun Li, Nicholas L. Fletcher, Dewan T. Akhter, Sandy Jarrett, Jun Zhang, Chengzhong Yu, Kristofer J. Thurecht, Timothy J. Mahony, Neena Mitter
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Development of veterinary subunit vaccines comes with a spectrum of challenges, such as the choice of adjuvant, antigen delivery vehicle, and optimization of dosing strategy. Over the years, our laboratory has largely focused on investigating silica
Externí odkaz:
https://doaj.org/article/0272e8159f11403db17d9bcafb772e35